Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Nutritional and Metabolic Diseases

Breast Neoplasms

Calcinosis

Metabolic Diseases

Calcium Metabolism Disorders

Arm1: patients undergo mammographic localizations and radiography of the specimen after surgical resection.

Arm2: patients undergo MRI localization and ex vivo MRI after surgical resection.

radiography

MRI (magnetic resonance imaging)

Roberto Agresti, MD

Radiography of breast specimens is currently the only radiological procedure used to verify removal of microcalcifications and presence of tumor-free margins after breast surgical resection. Ex vivo MRI will be tested for its ability to detect residual tumor tissue not detected by radiography in resected breast tumor specimens and/or its ability to verify tumor-free margins in breast cancer detected by MRI only.

A Study Comparing ex Vivo MRI Versus Radiography of Breast Specimens

A Randomized Study Comparing ex Vivo MRI Versus Radiography of Breast Specimens in Evaluating Tumor-free Margins After Surgical Resection of Breast Microcalcifications

Diagnostic efficacy will be evaluated by statistical analysis

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Leiomyoma

Myofibroma

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Neoplasms, Connective Tissue

Connective Tissue Diseases

MRE is performed at the end of the examination after the standard MRI protocol. A test vibration is first applied on the patient to familiarize the patient with the vibration. The MRE sequence is performed with either a body coil or a pelvic-array coil. The total acquisition time is split into four periods of suspended respiration of 16 seconds for acquisition of wave images at four phase offsets. To obtain a consistent position of the fibroid for each phase offset, patients are asked to quietly breath and remain still.

MR Elastography

David A. Woodrum, M.D., PhD.

The purpose of this study is to gain additional information regarding use of Magnetic Resonance Elastography (MRE) for uterine fibroid characterization. In this study, the investigators will use a new noninvasive technology, MRE, to further characterize the elastic properties of the uterine fibroids. To date, very little is known concerning how the tissue composition of the uterine fibroid may affect its treatment with Magnetic Resonance Guided Focused Ultrasound (MRgFUS).

In this study, the investigators will use a new noninvasive technology, magnetic resonance elastography (MRE), to further characterize the elastic properties of the uterine fibroids. This information will be gathered during routine magnetic resonance imaging for symptomatic uterine fibroids. It is known that some fibroids with increased T2-signal on Magnetic Resonance Imaging(MRI) can be more difficult to treat.

This information will be gathered during routine magnetic resonance imaging for symptomatic uterine fibroids.

This is a single-site, non-randomized pilot study to determine whether Magnetic Resonance Elastography (MRE) can be optimized for clinical use as part of the patients routine clinical imaging and to correlate with MR signal characteristics of the uterine fibroid.

MRE is performed at the end of the examination after the standard Magnetic Resonance Imaging protocol.

Aims:

Specific Aim 1: To acquire magnetic resonance elastography images on women who have a clinically ordered pelvic magnetic resonance imaging (MRI) for uterine fibroids.

Specific Aim 2: To examine the correlation between MRE stiffness values and MR T2 signal characteristics for uterine fibroids. For a subset of patients going on to surgery correlation with pathology can also be performed.

This study will seek to determine whether MRE can be performed in the pelvis on a routine clinical basis as well as correlating the MRE findings with magnetic resonance signal characteristics. There are no additional risks to the patient and no additional cost to the MRI exam.

Magnetic Resonance Elastography (MRE) of Uterine Fibroids

MRE is performed at the end of the examination after the standard Magnetic Resonance Imaging(MRI) protocol.

To examine the correlation between MR elastography stiffness values and MR T2 signal characteristics for uterine fibroids. For a subset of patients going on to surgery correlation with pathology can also be performed.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Study Comparing ex Vivo MRI Versus Radiography of Breast Specimens	NCT01869335	Breast Cancer	radiography MRI (magnetic r...	18 Years - 80 Years	Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
A Study Comparing ex Vivo MRI Versus Radiography of Breast Specimens	NCT01869335	Breast Cancer	radiography MRI (magnetic r...	18 Years - 80 Years	Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Magnetic Resonance Elastography (MRE) of Uterine Fibroids	NCT01229826	Uterine Fibroid...	MR Elastography	18 Years - 65 Years	Mayo Clinic

Spots Global Cancer Trial Database for mri (magnetic resonance imaging)