Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Prostatic Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Patients will undergo an MRI guided biopsy and standard trans-rectal ultrasonography-guided (TRUS) biopsy. Results will be compared to see which can more accurately diagnose and manage prostate cancer

The MRI guided biopsy will preferentially be performed using a 3 tesla (3T) Siemens Verio, or 3T Siemens Skyra machine. The multiparametric MRI exam will consist of T1-, T2- and diffusion weighted imaging with or without post-contrast perfusion studies. magnetic resonance fingerprinting (MRF) will be performed before contrast injection. The MRI will be interpreted by two specified radiologists from the research team.

MRI guided biopsy

The TRUS biopsy will be performed per current standard of care. Biopsy cores will be sent to pathology in separately labeled specimen cups. The final pathological results will be compared with pre-biopsy MRI findings.

TRUS biopsy

Lee Ponsky, MD

MRI is being increasingly relied upon for detection, staging and management of prostate cancer. In this study patients with risk of prostate cancer will be recommended to have a pelvic MRI prior to the standard biopsy of the prostate and standard treatment of any detected prostate cancer. The results of the MRI will be compared to standard diagnosis techniques to see if cancer can be more accurately detected.

The study team hypothesizes that strategic use of advanced MRI methods will provide a more accurate and less invasive approach for diagnosis and management of prostate cancer. The primary objectives are:

1. To develop advanced MRI methods and optimal MRI protocols for detection, staging, and follow-up of prostate cancer.
2. To evaluate the diagnostic performance of MRI-guided biopsy methods and correlate MRI findings with the pathological grade of cancer.
3. To correlate prostate MRI findings and biopsy results with patient progress and outcomes.
4. To evaluate the diagnostic accuracy of MRI in disease re-classification in patients on active surveillance.

Secondary Objectives:

1. To apply computer-aided advanced image analytic techniques (Computer-assisted diagnostics- CAD) to extract MRI features of patient clinical scans that correlate with diagnosis and grade of prostate cancer.
2. To study MRI features of lesions that mimic prostate cancer on imaging eg - chronic prostatitis, post treatment changes.
3. To evaluate the impact of MRI in decision making and choice of treatment by physicians and patients.

Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate Cancer

Assessment of Advanced Imaging Techniques in the Evaluation and Management of Prostate Cancer

Prostate imaging reporting and data system (PIRADS) scale: 1. Benign; 2. Probably benign; 3. Indeterminate; 4. Probably malignant; 5. Malignant

1. Benign; 2. Probably benign; 3. Indeterminate; 4. Probably malignant; 5. Malignant

The score based on the true diagnosis and most likely diagnosis as agreed on by classifiers is the same in at least 80% of patients

The diagnostic performance of MRI guided biopsy techniques will be compared with standard TRUS biopsy using a single sample of patients undergoing both biopsy techniques. It has been reported that MRI consistently detects a larger number of clinically significant prostate cancers (sensitivity - 0.91 for MRI-guided biopsy vs 0.76 for TRUS biopsy), while avoiding the detection of cancers that are clinically insignificant, as compared to TRUS biopsy.

Case Comprehensive Cancer Center

Targeted MRI guided biopsy according to findings in a multiparametric MRI followed by transrectal guided biopsy

MRI guided prostate biopsy and TRUS guided biopsy

Christian Arsov, MD

The purpose of this study is to determine whether MRI guided prostate biopsy achieves higher prostate cancer detection rates compared with transrectal ultrasound guided prostate biopsy in patients with increased PSA values \> 4.0 ng/ml.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate Cancer	NCT03122470	Prostate Cancer	MRI guided biop... TRUS biopsy	40 Years - 90 Years	Case Comprehensive Cancer Center
A Prospective Study to Evaluate MRI Guided Biopsy Compared With Transrectal Ultrasound Guided Biopsy of the Prostate in Men With Increased PSA Values	NCT01553838	Prostate Cancer	MRI guided pros...	18 Years -	Heinrich-Heine University, Duesseldorf
A Prospective Study to Evaluate MRI Guided Biopsy Compared With Transrectal Ultrasound Guided Biopsy of the Prostate in Men With Increased PSA Values	NCT01553838	Prostate Cancer	MRI guided pros...	18 Years -	Heinrich-Heine University, Duesseldorf
Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate Cancer	NCT03122470	Prostate Cancer	MRI guided biop... TRUS biopsy	40 Years - 90 Years	Case Comprehensive Cancer Center
A Prospective Study to Evaluate MRI Guided Biopsy Compared With Transrectal Ultrasound Guided Biopsy of the Prostate in Men With Increased PSA Values	NCT01553838	Prostate Cancer	MRI guided pros...	18 Years -	Heinrich-Heine University, Duesseldorf
Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate Cancer	NCT03122470	Prostate Cancer	MRI guided biop... TRUS biopsy	40 Years - 90 Years	Case Comprehensive Cancer Center

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