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Kava

Patients whose inferior vena cava vascular wall is invaded according to histopathological examination.

Patients whose inferior vena cava vascular wall is not invaded according to histopathological examination.

Inferior vena cava vascular wall is invaded according to pathologic examination on the postoperative tumor thrombus/ vascular wall specimen.

Vascular wall invaded

Jiyuan Chen, MD

Zhuo Liu, Doctor

Zhuo Liu, MD

The goal of this observational study is to establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations, as well as a accurate and systematic pathological grading standard of inferior vena cava (IVC) vascular wall invasion in renal cell carcinoma (RCC) with tumor thrombus invading vascular wall.The main questions it aims to answer are:

* To establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations.
* To determine what impact does different vascular wall layer invasion make on the long-term prognosis in RCC with IVC tumor thrombus;
* To determine which layer invasion according to pathological examination make sense to clinical treatment (can significantly affect prognosis); Participants with IVC vascular wall invasion/ non-invasion are divided into experimental group (invaded group) or control group (non-invaded group) respectively according to pathological examinations, in order to establish a prospective cohort with three-year follow-up. The pathological characteristics of local recurrence and poor prognosis are summarized, and postoperative pathological diagnostic criteria of IVC vascular wall invasion and established. The local recurrence and distant recurrence outcomes are compared between experiment group and control group, in order to analyze the long-term influence of vascular wall invasion. Then the preoperative imaging diagnostic evaluation model will be established.

Radical nephrectomy and thrombectomy are essential surgical treatments for renal cell carcinoma (RCC) with inferior vena cava (IVC) tumor thrombus. IVC vascular wall invasion leads to higher recurrence risk and worse long-term prognosis. The diagnosis and treatment of RCC tumor thrombus with IVC vascular wall invaded are affected by prominent difficulties: First, there is a lack of the preoperative diagnostic evaluation system consisting to the postoperative histopathological examinations, which is regarded as the gold standard of vascular wall invasion, therefore hinders the development of the neoadjuvant therapy strategy and surgery plan; Besides, the pathological diagnostic criteria of IVC vascular wall adhesion or invasion is inconsistent among different centers, an accurate and systematic criteria is needed.

This study consecutively includes patients admitted in Peking University Third Hospital between January 2023 to January 2026, who were diagnosed with primary renal cell carcinoma with IVC tumor thrombus with/without vascular wall invasion, and accepted radical nephrectomy and at least one IVC thrombectomy (including IVC incision only, IVC partial resection, IVC diagonal resection, and IVC segmental resection). The patients with IVC vascular wall invasion/ non-invasion are divided into experimental group (invaded group) or control group (non-invaded group) respectively according to pathological examinations, in order to establish a prospective cohort with three-year follow-up. For the invaded group, micro invasion subgroup and tumor thrombus capsule subgroup analysis are conducted. The pathological characteristics of local recurrence and poor prognosis are summarized, and postoperative pathological diagnostic criteria of IVC vascular wall invasion and established. The local recurrence and distant recurrences outcomes are compared between experiment group and control group, in order to analyze the long-term influence of vascular wall invasion. Then the preoperative imaging diagnostic evaluation model were established: re-diagnose patients in two groups according to the established pathological diagnostic criteria, and divide them into truly-invaded group and truly-non-invaded group. Analyzing the preoperative abdominal ultrasound scan, contrast-enhanced ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI), thus explore the imaging characteristics of vascular wall invasion and establish the preoperative diagnostic model. This study aims at establish a preoperative imaging diagnostic model which highly consistent with the histopathological examinations, as well as a accurate and systematic pathological grading standard of IVC vascular wall invasion, therefore contribute to the development of a more accurate and effective preoperative treatment strategy and surgery plan.

Predicting Model Based on Evidence-based Pathological Diagnose Criteria for RCC Tumor Thrombus With IVC Wall Invasion

Preoperative Imaging Diagnostic Evaluation Model Based on Evidence-based Pathological Diagnose Criteria for Renal Cell Carcinoma Tumor Thrombus With Inferior Vena Cava Wall Invasion

The duration from the date of diagnosis to death or last follow-up, with no restriction on the cause of death.

Clinical manifestation related to the renal carcinoma

A universal grading system for renal tumor thrombus.

TNM stage according to the preoperative imaging.

Inferior vena cava residual blood flow according to ultrasonography.

Inferior vena cava vascular wall continuity according to ultrasonography.

Whether the inferior vena cava is completely occluded according to ultrasonography.

Whether the inferior vena cava enhanced synchronization with tumor thrombus according to ultrasonography.

Whether the tumor thrombus move when breathe according to ultrasonography.

Maximum inferior vena cava anterior-posterior diameter according to CT/ MRI.

Maximun coronal inferior vena cava diameter according to CT/ MRI.

Maximum inferior vena cava anterior-posterior diameter at the renal vein ostium according to CT/ MRI.

Maximun coronal inferior vena cava diameter at the renal vein ostium according to CT/ MRI.

The presence of bland thrombus in inferior vena cava according to CT/ MRI.

The presence of tumor thrombus growing against the direction of venous return according to CT/ MRI.

Radical nephrectomy and at least one kind of IVC thrombectomy (including IVC incision only, IVC partial resection, IVC diagonal resection, and IVC segmental resection)

Histological type of the tumor according to pathological examination.

TNM stage according to pathological examination.

The deepest Inferior vane cava vascular wall layer the tumor thrombus invaded.

The duration from the date of diagnosis to death, last follow-up, or cancer recurrence.

Location and time that the metastasis occurs.

Peking University Third Hospital

Attending Doctor

Digestive System Diseases

Carcinoma, Squamous Cell

Neoplasm Metastasis

Esophageal Neoplasms

Recurrence

Disease Progression

Gastrointestinal Neoplasms

Digestive System Neoplasms

Head and Neck Neoplasms

Gastrointestinal Diseases

Esophageal Diseases

Esophageal Cancer

John V Reynolds, MCh FRCS

A major focus of research in oncology is to identify patients who, following induction therapy, have a complete pathologic response, presenting opportunities for novel trials, including extended therapy or non-operative approaches, in addition to identifying cohorts who are resistant to the neoadjuvant therapy. The current gold standard for determining response to CRT is pathological evaluation following surgical resection, in particular the Mandard Tumour Regression Grade (TRG) or some modification thereof. At this time, however, there is no preclinical early response or post-treatment biomarker, nor endoscopic or radiologic assessment that predicts pathologic response prior to surgical resection.The aim of this study is to determine the accuracy of CT-PET for prediction of histopathologic response and/or oncologic outcome for patients with esophageal cancer.

The Predictive Value of CT-PET in Esophageal Cancer

CT-PET for Prediction of Histopathologic Response, Nodal Status and Oncologic Outcome Following Neoadjuvant Chemoradiation for Esophageal Cancer

Mandard tumor regression grade, ypT, ypN stage

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Predicting Model Based on Evidence-based Pathological Diagnose Criteria for RCC Tumor Thrombus With IVC Wall Invasion	NCT05589207	Carcinoma, Rena... Tumor Thrombus Neoplasm Invasi... Inferior Vena C...	Vascular wall i...	18 Years -	Peking University Third Hospital
The Predictive Value of CT-PET in Esophageal Cancer	NCT02385604	Esophageal Neop...		18 Years -	St. James's Hospital, Ireland
The Predictive Value of CT-PET in Esophageal Cancer	NCT02385604	Esophageal Neop...		18 Years -	St. James's Hospital, Ireland

Spots Global Cancer Trial Database for neoplasm grading