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Initially and after pre-operative chemotherapy To evaluate the differences in ADC values according to the malignancy degree of nephroblastoma in children

MRI DWI sequence (ADC values)

Evelina f Nazarova

Galina f Tereshchenko, PhD

Initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3T MR scanner or 1.5T MR scanner. A standard MRI study of the abdomen with contrast enhancement is performed. DWI (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps. Then, using Philips workstation (ISP 9.0, Philips, Netherlands), DWI mapping and ADC values collection (mm2/s) are performed. The placement of region of interest (ROI) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2.

After the preoperative abdomen MRI, a surgical treatment is performed. Histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). The data is entered into the database and the relationship between ADC values and histological degrees of malignancy of nephroblastoma is investigated

Initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3T MR scanner or 1.5T MR scanner, using 8-channel body coil. A standard MRI study of the abdomen with contrast enhancement is performed. DWI (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps (DWI 3b) with 3 b-factors (50; 600; 800 or others, optional). Then, using Philips workstation (ISP 9.0, Philips, Netherlands), DWI mapping and ADC values collection (mm2/s) are performed. The placement of region of interest (ROI) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2. The values are entered in the table due to the stage of the chemotherapy.

After the preoperative abdomen MRI, a surgical treatment is performed. Histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). The data is entered into the database and the relationship between ADC values and histological degrees of malignancy of nephroblastoma is investigated.

DWI in the Diagnosis of Histological Types of Nephroblastoma in Children

Diffusion-weighted Images as an Additional Method for Diagnosing Histological Types of Nephroblastoma in Children

Federal Research Institute of Pediatric Hematology, Oncology and Immunology

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
DWI in the Diagnosis of Histological Types of Nephroblastoma in Children	NCT04814758	Nephroblastoma ...	MRI DWI sequenc...	6 Days - 18 Years	Federal Research Institute of Pediatric Hematology, Oncology and Immunology
DWI in the Diagnosis of Histological Types of Nephroblastoma in Children	NCT04814758	Nephroblastoma ...	MRI DWI sequenc...	6 Days - 18 Years	Federal Research Institute of Pediatric Hematology, Oncology and Immunology

Spots Global Cancer Trial Database for nephroblastoma (wilms tumour)