Neoplasms

All Conditions

Rare Diseases

Carcinoma

Carcinoma, Neuroendocrine

Carcinoid Tumor

Neuroendocrine Tumors

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Adenocarcinoma

Neoplasms, Glandular and Epithelial

Neoplasms, Nerve Tissue

Neuroendocrine Tumor

Neuroepithelioma

Gastrointestinal Agents

All Drugs and Chemicals

Lansoprazole

Dexlansoprazole

Proton Pump Inhibitors

Antacids

Anti-Ulcer Agents

Enzyme Inhibitors

lansoprazole

Stan Van Uum, MD PhD

The goal of this study is to compare several methods for measurement of Chromogranin A in their ability to serve as a marker for disease activity in patients with neuroendocrine tumors.

Further, in a subgroup, we will determine if taking a proton pump inhibitor affects Chromogranin A levels.

Patient group: patients with neuroendocrine tumors (active or inactive) Healthy volunteers

Evaluation of Methods for the Determination of Chromogranin A in Routine Blood Samples

For determination of normal CgA range, we will recruit 60 healthy subjects (30 female, 30 male), in whom a single plasma sample will be obtained for measurement of CgA B For determination of CgA in patients with carcinoid disease (active or inactaive), we wil recruit 200 patients with carcinoid disease from our local neuroendocinre oncology clinic.

To determine the effect of PPI on chromogranin A concentration, we will recruit a subgroup of 12 healthy subjects who will take a bedtime lansoprazole 30 mg for 7 days. Fasting serum samples for CgA will be obtained at day 7 and 1, 2, 4, and 7 days after discontinuation of the PPI.

University of Western Ontario, Canada

Principle investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of Methods for the Determination of Chromogranin A in Routine Blood Samples	NCT01216267	Neuroendocrine ...	Lansoprazole lansoprazole	18 Years - 70 Years	University of Western Ontario, Canada
Evaluation of Methods for the Determination of Chromogranin A in Routine Blood Samples	NCT01216267	Neuroendocrine ...	Lansoprazole lansoprazole	18 Years - 70 Years	University of Western Ontario, Canada
Evaluation of Methods for the Determination of Chromogranin A in Routine Blood Samples	NCT01216267	Neuroendocrine ...	Lansoprazole lansoprazole	18 Years - 70 Years	University of Western Ontario, Canada

Spots Global Cancer Trial Database for neuroendocrine carcinoma (carcinoid)