Neoplasms

Symptoms and General Pathology

All Conditions

Nervous System Diseases

Behaviors and Mental Disorders

Neoplasm Metastasis

Brain Neoplasms

Neoplastic Processes

Central Nervous System Neoplasms

Nervous System Neoplasms

Brain Diseases

Central Nervous System Diseases

Quality of Life

Image-Guided Hypofractionated Stereotactic Radiation Therapy (IGRT) of the resection cavity

Stereotactic Radiosurgery of the resection cavity (SRS)

IGRT

Gianfranco A Pesce, MD

Stereotactic radiosurgery or hypofractionated radiotherapy of the resection cavity after metastasectomy in cancer patients with brain metastases

Patients with limited number of brain metastases from solid tumors are at high risk of local recurrence after surgical removal of the tumor mass. The standard Whole-brain radiotherapy (WBRT) demonstrated to reduce the risk of recurrence without improving survival. At the same time WBRT have substantial acute and late toxicity. Preliminary experiences with Stereotactic radiosurgery or hypofractionated radiotherapy of the resection cavity indicate promising local control and good tolerance. This attitude was only partially explored in prospective trials. In this research patients with limited number of brain metastases and controlled systemic disease will be treated, with such a stereotactic irradiation, at the same time with evaluation of the local control (Primary endpoint) by repeated MRI and of quality of life, neurologic functionning (with a battery of thsts, e.g. MMSE, QLQ-C30, EORTC BN-20) as well as overall survival as secondary endpoints.

Hypofractionated Brain Radiationcavity

Stereotactic Radiosurgery or Hypofractionated Image-Guided Radiotherapy to the Surgical Cavity After Resection of Brain Metastases: a Multicenter, Single Arm, Open-label, Phase II Trial

Evaluate the recurrence probability in the surgical cavity after radiotherapy

The proportion of surviving patients at 1 year

The proportion of patients with progression of disease in any location other than the brain, according to CTCAE Criteria

Time to neurological deterioration (objective neurological examination and MMSE)

Evaluation of the quality of life through questionnaire

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Hypofractionated Brain Radiationcavity	NCT03561896	Brain Metastase... Cancer Brain	IGRT SRS	18 Years -	Oncology Institute of Southern Switzerland
Hypofractionated Brain Radiationcavity	NCT03561896	Brain Metastase... Cancer Brain	IGRT SRS	18 Years -	Oncology Institute of Southern Switzerland

Spots Global Cancer Trial Database for neurologic functionning