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Cognitive Dysfunction

Chemotherapy-Related Cognitive Impairment

Breast Diseases

Skin Diseases

Patient enrolled in a cognitive rehabilitation program using Neurotablet® and paper and pencil exercises

Patient NOT enrolled in a cognitive rehabilitation program using Neurotablet® and paper and pencil exercises.

The experimental group will carry out cognitive rehabilitation using the Neurotablet device. The cognitive rehabilitation will be performed for 10 consecutive weeks, once a week for 1 hour. Neuropsychological evaluations will be conducted before the start of chemotherapy (T0), 6 months (T1) and 12 months (T2) after the start of chemotherapy. Neuropsychological evaluations will include tests to analyze the main cognitive domains of memory, attention, executive functions and learning.

Neurotablet® and Neuropsychological evaluations

Neuropsychological evaluations will be conducted before the start of chemotherapy (T0), 6 months (T1) and 12 months (T2) after the start of chemotherapy. Neuropsychological evaluations will include tests to analyze the main cognitive domains of memory, attention, executive functions and learning.

Neuropsychological evaluations

Ornella Garrone, MD

An interventional, non-pharmacological, monocentric study evaluating the effectiveness of cognitive rehabilitation in counteracting chemotherapy-induced cognitive impairment (CRCI) in women with operable breast cancer treated with neo-adjuvant therapy and/ or adjuvant therapy.

This interventional, non-pharmacological, monocentric study examines the effectiveness of cognitive rehabilitation in counteracting CRCI in women with operable breast cancer treated with neo-adjuvant therapy and/ or adjuvant therapy.

A total of 128 patients will be randomized 1:1 into two groups:

* Experimental group, which will participate in a cognitive rehabilitation program using Neurotablet® and paper and pencil exercises. To evaluate the efficacy of the cognitive rehabilitation program, neurocognitive evaluations will be performed.
* Control group, which will only carry out neuropsychological assessments.

Neuropsychological evaluations will be conducted before the start of chemotherapy (T0), 6 months (T1) and 12 months (T2) after the start of chemotherapy. Neuropsychological evaluations will include tests to analyze the main cognitive domains of memory, attention, executive functions and learning.

CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)

CHEMioterapia e Deterioramento cOgnitivo Nelle Pazienti aFfette da Carcinoma Mammario

Test the effectiveness of a 10-week cognitive rehabilitation program in limiting or preventing chemotherapy-induced cognitive impairment. To test the efficacy of this cognitive rehabilitation program, neurocognitive evaluations will be performed.

Analysis of cognitive function trends though neurocognitive evaluations

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)	NCT06435559	Breast Cancer	Neurotablet® an... Neuropsychologi...	18 Years - 75 Years	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)	NCT06435559	Breast Cancer	Neurotablet® an... Neuropsychologi...	18 Years - 75 Years	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)	NCT06435559	Breast Cancer	Neurotablet® an... Neuropsychologi...	18 Years - 75 Years	Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Spots Global Cancer Trial Database for neurotablet® and neuropsychological evaluations