Neoplasms

All Conditions

Digestive System Diseases

Gland and Hormone Related Diseases

Rare Diseases

Carcinoma

Stomach Neoplasms

Pancreatic Neoplasms

Duodenal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Intestinal Diseases

Duodenal Diseases

Stomach Cancer

Esophageal Cancer

Pancreatic Cancer

Hematinics

All Drugs and Chemicals

Liver Extracts

Intervention group receives multimodal therapy with whole-body electromyostimulation and exercise therapy (WB-EMS) as well as conventional nutritional counseling with guidelines and digital nutritional coaching

Control group receives multimodal therapy with moderate conventional exercise training in a group and conventional nutritional counselling with guidelines and digital nutritional coaching

supervised group training sessions at least once and optionally twice a week, lasting 11-20 minutes, over 12 weeks, 12-24 training sessions in total

mid-frequency whole-body electromyostimulation (WB-EMS)

supervised group training at least once a week, optional additional home-based training once a week, lasting 40 minutes, over 12 weeks, 12-24 training sessions in total

conventional exercise training

conventional nutritional counselling with guidelines and digital nutritional coaching

nutritional therapy

Helen Schörghofer

Freerk T Baumann, Univ.-Prof.

The purpose of this study is to assess the efficacy of modulated mid-frequency whole-body electromyostimulation (WB-EMS) combined with nutritional therapy in patients with gastrointestinal cancer.

This study aims to combine the applicability and effectiveness of a form of strength training with targeted nutritional training. For this purpose, training with electromyostimulation (application of modulated mid-frequency; WB-EMS) is carried out, which pursues the effect of cell activation and the improvement of muscle strength. The primary aim of the multimodal intervention presented here is to increase muscle mass and improve energy utilisation and metabolism. Patients should experience increased mobility and independence as a result of this intervention. In the study, patients are randomly assigned to one of two groups, with one group receiving an application of electricity and the other group performing standardised exercise therapy without electricity. Otherwise, the groups do not differ in the applications or tests. In addition, nutritional coaching takes place in both groups with digital nutritional coaching.

Patients with a malignant tumour of the oesophagus, stomach, duodenum or colon or rectum with medical therapy administered before or after surgery (neoadjuvant and adjuvant therapy) and after surgery without further therapy can participate in the study.

The aim is to compare the use of electromyostimulation in this multimodal approach regarding its effectiveness in terms of muscle growth compared to the conventional multimodal approach. The research hypothesis is that the additional training stimulus provided by the application of electricity leads to significantly higher muscle growth than conventional training without electricity.

Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients

The Efficacy of Modulated Mid-frequency (Whole-body Electromyostimulation) and Nutritional Therapy in Patients With Solid Tumors of the Gastrointestinal Tract (Excluding Liver and Pancreatic Carcinomas)

All IPD that underlie results in a publication

Muscle mass of the quadriceps muscle (vastus lateralis / rectus femoris), cross-sectional diameter (CSD) using ultrasound. Muscle ultrasound represents a cheap and user-friendly, yet robust and reliable, method to monitor muscle mass.

Body composition including skeletal muscle mass, fat free mass, fat mass, total body water, body cell mass and extracellular mass, using bioimpedance analysis (BIA) (Nutriguard-MS)

Performance Status, with the help of Karnofsky Index (range 0 - 100, higher = better)

Endurance capacity, using spiroergometry measuring maximal oxygen uptake (VO2 max) (higher = better)

Lower limb performance, using 1 minute sit-to-stand test (higher = better)

Upper limb performance, using hand grip strength dynamometry (higher = better)

Fatigue symptoms, using the 13-item Functional Assessment of Chronic Illness Therapy - Fatigue Scale (FACIT Fatigue Scale). The FACIT-Fatigue is a 13-item measure that assesses self-reported fatigue and its impact on daily activities and function. Score range 0-52 (higher = better)

Quality of life, using the EORTC QLG Core Questionnaire (EORTC QLQ-C30). The EORTC QLQ-C30 is a 30-item instrument meant to assess some of the different aspects that define the quality of life of cancer patients. Score range 0-100 (higher = better)

University of Cologne

Behaviors and Mental Disorders

Quality of Life

Hypoglycemic Agents

Insulin

Insulin, Globin Zinc

Beverly Kotsanis

Constantine A. Kotsanis, MD

The investigator is looking for patients who have been diagnosed with stage 1-4 cancer to enroll in a five year Quality of Life clinical trial study in which the participant has previously elected to use Insulin Potentiation Targeted Low Dose (IPTLD) as a means to treat their illness. This study is a quality of life study and not a treatment study. Participants participating in the study will be asked to complete quality of life questionnaires. The questionnaires completed by the patients will measure mood, energy level, ability to function, level of pain, and other measures that indicate how a patient feels about the quality of their daily living.

Patients will complete surveys once per month during their participation in the quality of life study, and then a series of follow-up surveys: every two months the second year; every three (3) months the third year and every six months the fourth and fifth year.

A Five-Year Quality of Life Study for Cancer Patients

A Quality of Life Study Using Insulin Potentiation Targeted LowDose (IPTLDSM ) Chemotherapy and Nutrition Therapy in the Treatment of Cancer - The IPTLDSM QoL Broad Study

Best Answer for Cancer Foundation

Constantine A. Kotsanis

Principle Investigator, M.D.

Intensive nutritional interventions based on real-world treatments

Nutritional guidance and education based on real world treatments

Intensive nutritional therapy based on real world therapy

Nutritional therapy

Kai Li, MD

To evaluate the nutritional status of patients with different types of tumors by continuous nutritional intervention and follow-up intervention in the perioperative period,and the impact on progression-free survival/survival and quality of life.

Nutritional Intervention for Patients With Multiple Cancer Types

An Open, Real-world Study of the Effects of Perioperative Intensive Nutritional Management on Short-term Quality of Life and Long-term Life Outcomes in Patients With Multiple Cancers

Perioperative survival index of patients with multiple cancer types

First Hospital of China Medical University

Deputy Director of surgical Oncology

Blood and Lymph Conditions

Immune System Diseases

Symptoms and General Pathology

Leukemia

Leukemia, Lymphoid

Leukemia, Lymphocytic, Chronic, B-Cell

Neoplasms by Histologic Type

Hematologic Diseases

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Leukemia, B-Cell

Chronic Disease

Disease Attributes

Chronic Graft Versus Host Disease

Chronic Lymphocytic Leukemia

Micronutrients

Vitamins

Group receiving dermal chelation and nutritional therapy

Dermal chelation with Aqua DetoxTM system for one or more hours one or more times each week.

Dermal Chelation

Vitamins and minerals that will be taken one or more times a day.

Nutritional Therapy

The purpose of this clinical trial is to identify 50 participants with Chronic Lymphocytic Leukemia (CLL) and follow their total white blood cell (WBC) counts and absolute lymphocyte counts after performing dermal chelation and administering nutritional therapy

The purpose of this clinical trial is to use dermal chelation and hair tissue analysis to identify 50 participants with CLL. The total wbc counts and absolute lymphocyte counts of these participants will be followed after serial dermal chelations and nutritional therapy.

Chronic Lymphocytic Leukemia Responds to Dermal Chelation

Dermal Chelation Lowers White Blood Cell Count in Chronic Lymphocytic Leukemia

Total WBC counts taken on a regular interval.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients	NCT06414122	Oesophageal Can... Gastric Cancer Duodenal Cancer Colorectal Canc...	mid-frequency w... conventional ex... nutritional the...	18 Years -	University of Cologne
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients	NCT06414122	Oesophageal Can... Gastric Cancer Duodenal Cancer Colorectal Canc...	mid-frequency w... conventional ex... nutritional the...	18 Years -	University of Cologne
A Five-Year Quality of Life Study for Cancer Patients	NCT01539148	Cancer		18 Years -	The Kotsanis Institute
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients	NCT06414122	Oesophageal Can... Gastric Cancer Duodenal Cancer Colorectal Canc...	mid-frequency w... conventional ex... nutritional the...	18 Years -	University of Cologne
Nutritional Intervention for Patients With Multiple Cancer Types	NCT06059560	Cancer	Nutritional the...	18 Years - 80 Years	First Hospital of China Medical University
Chronic Lymphocytic Leukemia Responds to Dermal Chelation	NCT03495492	Chronic Lymphoc...	Dermal Chelatio... Nutritional The...	18 Years -	Optimum Health, Natural Healthcare Center
Chronic Lymphocytic Leukemia Responds to Dermal Chelation	NCT03495492	Chronic Lymphoc...	Dermal Chelatio... Nutritional The...	18 Years -	Optimum Health, Natural Healthcare Center

Spots Global Cancer Trial Database for nutritional therapy