Neoplasms

Digestive System Diseases

All Conditions

Symptoms and General Pathology

Blood and Lymph Conditions

Colorectal Neoplasms

Hypertrophy

Lymphadenopathy

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Lymphatic Diseases

Lymph nodes with a diameter \> 8 mm on preoperative imaging without metastasis on postoperative pathology were termed benign mesenteric lymph node enlargement.

Lymph nodes with a diameter \< 8 mm on preoperative imaging without metastasis on postoperative pathology were termed non-benign mesenteric lymph node enlargement.

Lymph nodes with a diameter \> 8 mm on preoperative imaging with metastasis on postoperative pathology were termed metastatic mesenteric lymph node enlargement .

Observational study, no intervention

Junwei Wang, M.D.

The objective of this observational study was to investigate the clinical significance of benign mesenteric lymph node （BLNE） enlargement in patients with colorectal cancer. The main questions it aims to answer are:

Do patients with benign mesenteric lymph node enlargement have a better prognosis? What are the clinical characteristics of benign mesenteric lymph node enlargement? As part of routine medical care for colorectal cancer, we will follow up with all participants over the course of the study.

From January 2015 to June 2023, 2,270 patients with colorectal cancer received surgical treatment at Peking University Third Hospital. The clinical data of these patients were recorded retrospectively and the eligible patients were divided into two groups. According to the 9th edition of the TNM staging System published by the AJCC, the BLNE group included the mesenteric BLNE group, while the non-benign lymph node enlargement (NBLNE) group was the control group. Inclusion criteria were :1) No regional lymph node metastasis or distant metastasis; 2) Stage I and II patients with AJCC staging system; 3) Radical CRC resection reached R0 status, no positive lymph nodes; Colonoscopy confirmed a single malignant lesion. Exclusion criteria :1) emergency surgery or preoperative complications such as intestinal obstruction and perforation; 2) Positron emission tomography (PET-CT) suspected distant metastasis; 3) Preoperative neoadjuvant therapy; 4) Hereditary colorectal cancer such as familial adenomatous polyposis; Microsatellite instability (MSI) was confirmed by pathology. In early colorectal cancer, MSI-H status is associated with a favorable prognosis and enhanced anti-tumor immune response. Therefore, we excluded these patients to avoid their influence on prognosis. 6) Lack of imaging data; 7) Loss of follow-up.

Significance of Benign Lymph Node Enlargement in Colorectal Cancer

From the time participants started undergoing radical surgery until their tumors returned or they died from tumor causes. The unit is month.

The time from the time participants began undergoing radical surgery until they died from any cause. Unit is month.

Peking University Third Hospital

Rare Diseases

Oculocerebral Syndrome With Hypopigmentation

Herbal and Botanical

All Drugs and Chemicals

Cola

People who are diagnosed with CRC by colonoscopy and pathological biopsy

People who are diagnosed with CRA by colonoscopy and pathological biopsy

People who are diagnosed with CRP by colonoscopy and pathological biopsy

People who have no obvious abnormality in the whole colon

observational study, no intervention

Hu Mengyao

He Xiaolong, Professor

The goal of this observational study is to explore the association of peptidoglycan fragments derived from gut microbiota with colorectal cancer (CRC). The main question it aims to answer is: Are peptidoglycan fragments from the gut microbiota associated with the progression of colorectal cancer? Participants will provide biological specimens (blood, feces, colon tissue obtained during surgery)

To explore whether peptidoglycan fragments can be used as screening or diagnostic indicators for colorectal cancer

A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Colorectal Cancer

The content of peptidoglycan fragments was detected by HPLC-MS/MS

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Significance of Benign Lymph Node Enlargement in Colorectal Cancer	NCT06410729	Colorectal Neop...	Observational s...	-	Peking University Third Hospital
A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Colorectal Cancer	NCT06379412	Colorectal Canc...	observational s...	-	Zhujiang Hospital
Significance of Benign Lymph Node Enlargement in Colorectal Cancer	NCT06410729	Colorectal Neop...	Observational s...	-	Peking University Third Hospital
Significance of Benign Lymph Node Enlargement in Colorectal Cancer	NCT06410729	Colorectal Neop...	Observational s...	-	Peking University Third Hospital

Spots Global Cancer Trial Database for observational study, no intervention