Symptoms and General Pathology

All Conditions

Neoplasms

Immune System Diseases

Skin and Connective Tissue Diseases

Rare Diseases

Syndrome

Mastocytosis

Urticaria

Mast Cell Activation Syndrome

Mast Cell Activation Disorders

Urticaria Pigmentosa

Skin Diseases

Skin Diseases, Vascular

Hypersensitivity

Hypersensitivity, Immediate

Neoplasms, Connective Tissue

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Mastocytosis, Cutaneous

Skin Neoplasms

Pigmentation Disorders

Participants affected by cutaneous and systemic mastocytosis with or without eye disabilities

Eye examination :

Ocular tonometry to determine intraocular pressure Refraction assessment Retina examination Slit lamp examination Visual acuity Schirmer's test Corneal topography Funduscopic examination Optical coherence tomography

Ophthalmological examination

Mastocytosis is a rare condition characterized by an accumulation of mast cell cells in one or more organs such as the liver, bone marrow, spleen and intestines. Its prevalence in the general population is 1 in 10,000.

This pathology is due to the proliferation of a mast cell clone and the excessive release of inflammatory mediators which lead to abnormal tissue infiltration.

To date, there are only a few cases reporting ocular and orbital manifestations of mastocytosis.

Our prospective, interventional and single-center study consist in describing the ocular functional manifestations and ocular surface abnormalities of patients with systemic and cutaneous mastocytosis.

Patient with systemic or cutaneous mastocytosis will be included in the study. Data about organ involvement of mastocytosis will be collected. Participants will be screened with a medical and eye disease history. They will also have an eye exam.

Participants will provide a tears sample.

Ocular and Palpebral Manifestations of Mastocytosis (MOOMA)

Number of patients with functional complaints or abnormalities of the surface, orbit, anterior and posterior segment of the eyeball.

Details of functional complaints, abnormalities of various specialized examinations such as ocular tonometry to determine intraocular pressure, Refraction assessment, Retina examination, Slit lamp examination, Visual acuity, Schirmer's test, Corneal topography, Funduscopic examination, Optical coherence tomography

Significative association with a mastocytosis subtype or certain organ involvements or biological abnormalities

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Ocular and Palpebral Manifestations of Mastocytosis (MOOMA)	NCT04978740	Mast Cell Activ... Mast Cell Activ... Mast Cell Disea... Urticaria Pigme...	Ophthalmologica...	18 Years -	Poitiers University Hospital
Ocular and Palpebral Manifestations of Mastocytosis (MOOMA)	NCT04978740	Mast Cell Activ... Mast Cell Activ... Mast Cell Disea... Urticaria Pigme...	Ophthalmologica...	18 Years -	Poitiers University Hospital

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