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Acute Graft Versus Host Disease

Neuromyelitis Optica Spectrum Disorder

Transverse Myelitis

Acute Disseminated Encephalomyelitis

Chronic Graft Versus Host Disease

Benjamin Greenberg, M.D., M.H.S.

To establish a large, longitudinal collection of high quality samples and data from subjects with MS, selected other demyelinating diseases (Transverse Myelitis (TM), Neuromyelitis Optica (NMO) or Devic's, Acute Disseminated Encephalomyelitis (ADEM), and Optic Neuritis (ON)), and related and unrelated unaffected controls. Samples and data will be available as a shared resource to scientists researching the causes, sub-types, and biomarkers of MS and related demyelinating diseases.

Biobank For MS And Other Demyelinating Diseases

Large-scale, Multi-disciplinary Sample and Data Repository for Multiple Sclerosis and Related Demyelinating Diseases

Accelerated Cure Project for Multiple Sclerosis

Skin and Connective Tissue Diseases

Ganglion Cysts

Synovial Cyst

Cysts

Mucinoses

Connective Tissue Diseases

Andréane Lavallée, MD, FRCSC

BACKGROUND AND OBJECTIVES: The recent expansion of the applications of optical coherence tomography (OCT) demonstrated a higher correlation between the analysis of ganglion cells and visual function, in comparison with the analysis of the nerve fiber layer for several diseases of the optic nerve. Atrophy of the ganglion cells tends to induce the visual function deficits. In the case of optic neuritis, inflammation of the optic nerve causes a deficit of visual function initially with low vision, color blindness and visual field. Secondary atrophy of ganglion cell can result. The purpose of the study is to evaluate the correlation between the analysis of ganglion cells at the time of diagnosis of optic neuritis and the resulting visual acuity at 6 months and visual function (visual acuity, color vision and perimetry) 1 year regardless of treatment. A predictive effect could help predict the patient's clinical course and management of uncertainty and anxiety. MATERIALS AND METHODS: An assessment at diagnosis and follow-ups at 6 months and 1 year with a measurement of best corrected visual acuity, a test color vision HRR (Hardy-Rand-Rittler), an OCT with analysis of ganglion cells and perimetry Humphrey 30 -2 fast will be done. Simple linear and logistic regressions will be used. RESULTS: We expect that there will be a significant association between atrophy of ganglion cells in the diagnosis and residual visual function after an episode of optic neuritis. We believe that the initial atrophy is associated with poorer visual prognosis. CONCLUSION: A predictive effect could help to inform the patient about the evolution of the disease and provide early visual rehabilitation.

Optic Neuritis and Ganglion Cell Layer

Predictive Effect of Ganglion Cell Layer on Visual Acuity at 6 Months and on Visual Function at 1 Year After an Episode of Optic Neuritis

Evaluation of best corrected visual acuity at 6 months post optic neuritis episode in correlation with initial ganglion cell layer analysis measures in order to predict the visual acuity in the future.

Evaluation of the visual function (best corrected visual acuity, perimetry, color vision) at 12 months post optic neuritis episode in correlation with initial ganglion cell layer analysis measures in order to predict the visual acuity in the future.

CHU de Quebec-Universite Laval

Ophthalmologist

Patients diagnosed with NMOSD based on revised diagnostic criteria. Seronegative, anti-AQP4 seropositive and ant-MOG seropositive patients will be included

Patients who have had one demyelinating event, not diagnosed with multiple sclerosis and whom are considered at risk for NMO or NMOSD.

patients without a history of CNS inflammation

Jan Cameron-Watts, RN

Martha Mann, RN

Benjamin M Greenberg, MD, MHS

Benjamin M Greenberg, MD

This study seeks to determine the biologic causes of inflammation in patients with Transverse Myelitis (TM) Neuromyelitis Optica Spectrum Disorder (NMOSD) and related conditions. While patients will be treated according to decisions with their treating physician, this study will collect data and samples from patients prospectively to gain a better understanding of the disease. We are seeking to understand why some patients respond to medications, while others do not. We also seek to understand what happens biologically, preceding relapses. Gathering these data and samples will allow researchers to identify new ways of diagnosing and treating these diseases. Data and samples will be shared with researchers around the world to support collaborative efforts to treat these conditions.

This study seeks to determine the biologic causes of inflammation in patients with Neuromyelitis Optica (NMO), Transverse Myelitis (TM), optic neuritis (ON), related conditions and healthy controls. While patients will be treated according to decisions with their treating physician, this study will collect data and samples from patients prospectively to gain a better understanding of the disease. We are seeking to understand why some patients respond to medications, while others do not. We also seek to understand what happens biologically, preceding relapses. Gathering these data and samples will allow researchers to identify new ways of diagnosing and treating these diseases. Data and samples will be shared with researchers around the world to support collaborative efforts to treat these conditions.

Patients will agree to share medical records, complete questionnaires and donate samples on a timed basis.

Patients will donate serum, plasma, DNA, RNA and white blood cells.

The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders

Collaboration on Neuroimmunology: Question, Understand, Educate, Restore - The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders

Deidentified data can be shared with IRB approved researchers upon request and approval from PI

Standard clinical assessments include: relapse information, level of disability based on EDSS score, high and low contract visual acuity, ambulation index, optical coherence tomography, and MRI, and neurologic/physical exam

Cognition measures include the SDMT, JLO, and PASAT

Surveys include MSNQ, MSQOL-54, QIDS, BDI-II, FSS, ESS, MFIS, BPI, and Neuro-QoL

Measure B cell subtypes and changes over time

University of Texas Southwestern Medical Center

Director, Neuromyelitis Optica and Transverse Myelitis Program

Study title	NCT ID	Conditions	Eligibility	Organization
Biobank For MS And Other Demyelinating Diseases	NCT00445367	Multiple Sclero... Transverse Myel... Neuromyelitis O... Acute Dissemina... Optic Neuritis	-	Accelerated Cure Project for Multiple Sclerosis
Optic Neuritis and Ganglion Cell Layer	NCT02864134	Optic Neuritis	18 Years -	CHU de Quebec-Universite Laval
Biobank For MS And Other Demyelinating Diseases	NCT00445367	Multiple Sclero... Transverse Myel... Neuromyelitis O... Acute Dissemina... Optic Neuritis	-	Accelerated Cure Project for Multiple Sclerosis
Biobank For MS And Other Demyelinating Diseases	NCT00445367	Multiple Sclero... Transverse Myel... Neuromyelitis O... Acute Dissemina... Optic Neuritis	-	Accelerated Cure Project for Multiple Sclerosis
The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders	NCT01623076	Neuromyelitis O... Neuromyelitis O... Transverse Myel... Optic Neuritis	6 Years -	University of Texas Southwestern Medical Center

Spots Global Cancer Trial Database for optic neuritis