Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Mouth and Tooth Diseases

Symptoms and General Pathology

Rare Diseases

Keratosis, Actinic

Keratosis

Lichen Planus, Oral

Lichen Planus

Mouth Neoplasms

Leukoplakia

Leukoplakia, Oral

Skin Diseases

Precancerous Conditions

Lichenoid Eruptions

Exanthema

Skin Diseases, Papulosquamous

Head and Neck Neoplasms

Mouth Diseases

Stomatognathic Diseases

Pathological Conditions, Anatomical

Oral Cancer

Lip and Oral Cavity Cancer

Oral Leukoplakia

Analgesics

Central Nervous System Depressants

All Drugs and Chemicals

Vasodilator Agents

Respiratory System Agents

Nitrous Oxide

Nitric Oxide

salivary biomarker

weam Elbattawy, Phd

investigating the level of malondialdehyde (MDA) \& nitric oxide (NO) in saliva in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant and potentially malignant lesions.

Being a detrimental disease, cancer development is a very complicated process that requires many sequential steps and depends on a various number of genetic alterations and factors(1). Among these factors are the free radicals which are derived either from endogenous or exogenous sources (5). Free radicals result in an oxidative stress of the affected cells generating a body imbalance between oxidants and antioxidants (6).

In this regard, saliva has been currently used to assess this possible oxidative imbalance through various salivary biomarkers including nitric oxide (NO) and malondialdehyde (MDA). Saliva could be used as a very interesting rich medium, known for its role in diagnosis, prognosis and treatment that has become more prominent in oral diseases (6).

Nitric oxide (NO) is an intercellular messenger molecule having many important biological functions. The levels of nitric oxide in salivary secretions could be used to monitor the severity of many underlying disease processes. Moreover, malondialdehyde (MDA) has been the most frequently used biomarker of oxidative stress in many pathological conditions such as cancer. It resulted from reactive oxygen species lipid degradation and induced toxic stress in affected cells, making both biomarkers a point of focus in monitoring clinical progress of suspected lesions

Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions

all the data will shared once the work is published

The MDA level in saliva measured using ELISA kit provided by My BioSource, USA.

The nitric oxide level in saliva measured using ELISA kit provided by My BioSource, USA.

Beni-Suef University

principle investigator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions	NCT04267419	Oral Lichen Pla... Oral Cancer Leukoplakia Oral Keratoses	salivary biomar...	18 Years - 70 Years	Beni-Suef University
Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions	NCT04267419	Oral Lichen Pla... Oral Cancer Leukoplakia Oral Keratoses	salivary biomar...	18 Years - 70 Years	Beni-Suef University

Spots Global Cancer Trial Database for oral keratoses