Neoplasms

Musculoskeletal Diseases

Eye Diseases

All Conditions

Orbital Neoplasms

Skull Neoplasms

Bone Neoplasms

Eye Neoplasms

Bone Diseases

Orbital Diseases

Orbital masses develop at the expense of the orbital structures lacrimal glands, oculomotor muscles, optic nerve, meningeal spaces, peripheral nerves, bone wall, orbital fat, lymphoid structures or vascular structures. These masses can be tumors, benign or malignant, or pseudotumor, mainly represented by specific or non-specific orbital inflammation.

Pathology is of considerable importance for the diagnosis and the treatment of those masses. However, biopsy or surgical resection of the orbital masses is sometimes difficult and dangerous outside expert centers.

The identification of a non-invasive technique for distinguishing tumors from pseudotumors, thus avoid in some cases a biopsy, would be a major contribution for the patients.

For salivary glands, MRI allows to identify 4 different types of MRI characteristics, one (type C) being related to malignant tumors.

In this study, the investigators will try to see if extrapolation of those data to orbiltal tumors is feasible.

MRI Perfusion Curves Typology and Orbital Tumors (PERFORM)

Validation, for Orbital Tumors, of the MRI Perfusion Curves Typology Established for Salivary Tumors

Fondation Ophtalmologique Adolphe de Rothschild

Symptoms and General Pathology

Skin and Connective Tissue Diseases

Rare Diseases

Recurrence

Solitary Fibrous Tumors

Hemangiopericytoma

Neoplasms, Fibrous Tissue

Neoplasms, Connective Tissue

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Neoplasms, Vascular Tissue

Patients will be asked to complete a questionnaire via a phone call

Phone call

Natasha MAMBOUR

Orbital solitary fibrous tumors are rare tumors with an intermediate potential of malignancy. Orbital solitary fibrous tumors' prognostic criteria are still poorly understood.

Some patients with orbital solitary fibrous tumors have been treated at the Adolphe de Rothschild Foundation Hospital. This cohort will be studied to describe the recurrence rate and to identify predictive factors of recurrence or metastasis.

Descriptive Study of a Cohort of Orbital Solitary Fibrous Tumors

Orbital Solitary Fibrous Tumors: Description of a Case Series and Study of the Recurrence Rate

descriptive statistics of each variable: age, sex, symptoms, duration of symptoms

descriptive statistics of each variable: history of previous biopsy or excision, previous intraoperative data,previous pathological data

descriptive statistics of each variable: laterality, orbital location, size and characteristics on preoperative orbital imaging

descriptive statistics of each variable: presence of necrosis, presence of epithelioid morphology of these cells, presence of cellular atypia, description of the mitotic index, immunohistochemical study, proliferation factor

descriptive statistics of each variable: complete or incomplete surgical removal, surgical removal 'in toto' or by fragments

Orbital Pseudotumor

Orbital masses develop at the expense of the orbital structures lacrimal glands, oculomotor muscles, optic nerve, meningeal spaces, peripheral nerves, bone wall, orbital fat, lymphoid structures or vascular structures. These masses can be tumors, benign or malignant, or pseudotumor, mainly represented by specific or non-specific orbital inflammation.

Pathology is of considerable importance for the diagnosis and the treatment of those masses. However, biopsy or surgical resection of the orbital masses is sometimes difficult and dangerous outside expert centers.

The identification of a non-invasive technique for distinguishing tumors from pseudotumors, thus avoid in some cases a biopsy, would be a major contribution for the patients.

The MRI assessment performed routinely in a patient with an orbital mass includes morphological sequences T1, T2 fat suppression, T1 injected fat suppression, diffusion. This exploration requires, regardless of the performed research, a contrast agent injection (0.1 mg / kg weight of Gadobutrol®).

In this research protocol, during the injection of the contrast agent performed during the MRI assessment performed routinely, a DCE perfusion sequence, which consists of a repeated acquisition at short intervals of a volume gradient echo T1, will be added. This acquisition will be preceded by two short series for calibration. The post treatment will include parametric permeability cards (Ktrans) and plasmatic volume (Vp), evaluating one or more regions of interest in the tumor, normal lacrimal glands, jaw muscles and nasal mucosa being the reference. It will also be added a magnetic susceptibility EPI sequence type. All the qualitative parameters (T1, T2, T1 injected, distribution, low signal intensity in susceptibility) and quantitative (Ktrans, Vp, relative intensity enhancement, apparent diffusion coefficient) parameters will be collected.

The result of the pathological exam of the biopsy or of the surgical specimen, which is the gold-standard, will be collected.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
MRI Perfusion Curves Typology and Orbital Tumors (PERFORM)	NCT02434120	Orbital Tumor		18 Years -	Fondation Ophtalmologique Adolphe de Rothschild
Descriptive Study of a Cohort of Orbital Solitary Fibrous Tumors	NCT05613244	Orbital Tumor	Phone call	18 Years - 120 Years	Fondation Ophtalmologique Adolphe de Rothschild
MRI and Orbital Tumours (MEDORT)	NCT02401906	Orbital Tumor Orbital Pseudot...	MRI	18 Years -	Fondation Ophtalmologique Adolphe de Rothschild
MRI and Orbital Tumours (MEDORT)	NCT02401906	Orbital Tumor Orbital Pseudot...	MRI	18 Years -	Fondation Ophtalmologique Adolphe de Rothschild
Descriptive Study of a Cohort of Orbital Solitary Fibrous Tumors	NCT05613244	Orbital Tumor	Phone call	18 Years - 120 Years	Fondation Ophtalmologique Adolphe de Rothschild

Spots Global Cancer Trial Database for orbital tumor