Symptoms and General Pathology

All Conditions

Colonic Polyps

Polyps

Intestinal Polyps

Pathological Conditions, Anatomical

Psychotropic Drugs

All Drugs and Chemicals

Antidepressive Agents

Antidepressive Agents, Tricyclic

Patients will be scored using the "Orton Score," a novel clinical prediction tool to determine which patients are at risk for poor bowel preps and may benefit from an extended prep. If they score highly, they will receive an extended GoLytely bowel prep.

Patients will be scored using the "Orton Score," a novel clinical prediction tool to determine which patients are at risk for poor bowel preps and may benefit from an extended prep. If they do not score highly, they will receive a standard GoLytely (or Suprep) bowel prep.

Significant a priori predictors of poor prep included: male gender, COPD, diabetes with end-organ damage, severe neurologic disease, constipation medication use, and tricyclic antidepressant use. Proprietary web-based weighted scoring model allows screening clinician to predict which bowel prep would be best for patient depending on which risk factors patients have.

Orton Score

Clinician usual practice of prescribing bowel preps to patient

Typical Standard of Care

Brian J Wentworth, MD

Steven M Powell, MD

Esteban Figueroa, MD

Kimberly Richards, NP

Cindy Gentry, RN

Colonoscopy is a common endoscopic procedure which the UVA Gastroenterology \& Hepatology department performs on a daily basis for both screening/surveillance and diagnostic/therapeutic intent. As a safety net hospital, the institution also offers open access colonoscopy as a means of allowing outside primary care and urgent care providers a way to have patients receive necessary endoscopy services. However, these patients are not all seen in clinic prior to their procedure but are all prescribed a specific bowel prep by a medical professional who screens the referrals.

Given that the patient population described above are often not well-known to UVA providers, they may be prescribed prep regimens that are not ideal for their comorbidities. Not infrequently, these patients show up to their colonoscopies with an inadequate bowel prep, leading to either cancelled or incomplete procedures, increased healthcare and personal financial costs (such as missed wages from taking off work), suboptimal endoscopy resource utilization, and delay in or missed polyp (or potentially cancer) detection.

The investigators seek to use a novel scoring system designed to predict patients at risk for suboptimal preps (and hence patients that would benefit from an extended prep) and apply it in uniform fashion to a patient population most at risk for suboptimal preps. Because obtaining written consent is not practical given that these patients may not be seen by a UVA provider prior to their endoscopic procedure, the investigators will plan to verbally consent via the telephone in an all-inclusive manner; there will be no randomization but rather the selection of prep to be determined by the novel scoring system. Subjects be prescribed either a standard split-dose GoLytely prep (or SuPrep) or an extended split-dose GoLytely prep. The investigators predict that utilizing this new system will lead to a decreased number of inadequate bowel preps and will increase polyp detection. The investigators will work with a UVA biostatistician to analyze the data and use Chi Square, student's T tests, and logistic regression models to assess significance and help validate the model.

All patients will be assessed for the most appropriate bowel preparation prior to colonoscopy (standard vs. extended) based on a novel scoring tool that accounts for various clinical conditions.

Improving Outpatient Colonoscopy Bowel Prep With the Orton Score

Validation of a Novel Clinical Prediction Scoring System for Improved Bowel Preparation Prior to Outpatient Colonoscopy

Percentage of colonoscopies where performing endoscopist rates the prep as inadequate for intended purpose (screening/surveillance)

Percentage of colonoscopies with detection of at least 1 adenoma

Percentage of colonoscopies with detection of an adenoma with high-grade dysplasia, tubulovillous adenoma, or adenocarcinoma

Percentage of colonoscopies that are unable to be completed secondary to inadequate prep or technical difficulty

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Improving Outpatient Colonoscopy Bowel Prep With the Orton Score	NCT04093557	Colonic Polyp Colon Cancer	Orton Score Typical Standar...	18 Years - 100 Years	University of Virginia
Improving Outpatient Colonoscopy Bowel Prep With the Orton Score	NCT04093557	Colonic Polyp Colon Cancer	Orton Score Typical Standar...	18 Years - 100 Years	University of Virginia

Spots Global Cancer Trial Database for orton score

Every month we try and update this database with for orton score cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for orton score

Every month we try and update this database with for orton score cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for orton score cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.