Symptoms and General Pathology

All Conditions

Nervous System Diseases

Cancer Pain

Pain

Neurologic Manifestations

The patients meeting the inclusions criteria will be informed of the study and an osteopathic treatment holistic ,involving all the body will be applied, three time with 2 days between the treatments .Each meeting with the practitioner will last around 40 minutes. The pain and symptoms assessment will be done before and after the treatment .

Osteopathic treatment

Marilène FILBET, MD

Staying confined in the bed is frequent at the end of life. The cancer patients can also experiment this situation, and consequences are painful, with pain increasing with the time. This pain are related to the joints stiffing , muscles mass decreasing, and tendons retractions . The non pharmacological approach associated with the conventional treatments can be interesting to assess in this frails patients.

Osteopathy Treatment for Cancer Pain Related to the Confinement to Bed

Osteopathy Treatment for Cancer Pain Related to the Confinement to Bed Pilot Study

Hospices Civils de Lyon

Neoplasms

Skin and Connective Tissue Diseases

Behaviors and Mental Disorders

Breast Neoplasms

Breast Diseases

Skin Diseases

Quality of Life

Patients will have three sessions of osteopathy and 6 phone questionnaires.

Patients will have 6 phone questionnaires.

- Three osteopathy sessions every 14 days (D13, D27 and D41 post-surgery),

Osteopathy sessions

Six phone questionnaires (D9, D20, D26, D34, D40 and D48):

* pain questionnaire with digital scale,
* quality of life survey: SF-12
* HAD (Hospital and Anxiety Depression) questionnaire

phone questionnaires

Gil DUBERNARD, Pr

Breast cancer can be painful following surgery or can develop later and remain persistent. Pain occurrence is frequent with 50% of women developing sequelae pain of varying intensity with an impact on the quality of life. One of the priorities of the 3rd French Cancer Plan is to preserve quality of life.

Osteopathy, complementary therapy, may help to reduce inconvenience caused by the disease, treatments and their side effects (asthenia, anxiety and pain).

The main objective is to assess the impact of osteopathic treatment on pain in patients following breast cancer surgery. The impact will be considered beneficial if the pain score (digital scale) in the intervention group is lower, by at least two points, than the pain score in the control group at the end of the study.

This is a monocentric, randomized, parallel group, single-blind and prospective clinical trial.

Impact of Osteopathy on Pain After Breast Cancer Surgery

Study of the Impact of Osteopathic Care, Complementary Therapy to Standard Care, on Pain in Patients With Breast Cancer Surgery

The primary outcome measure will be the evaluation of the "usual pain in the last eight days" measured from the pain score (digital scale). The pain score consists of asking the patient to quantify her pain on a virtual scale from 0 (absent pain) to 10 (worst pain imaginable).

Assessment of quality of life by the SF-12 questionnaire, which is a shortened version of the " Medical Outcomes Study Short-Form General Health Survey " (SF-36), comprising only 12 of the 36 issues. The SF-12 is used to calculate two scores, which measure the functional health and well-being of the patient.

Assessment of anxiodepressive disorders from the HAD scale (Hospital and Anxiety Depression), each response is rated from 0-3 on a scale evaluating semi-quantitatively the intensity of symptoms during the past week. This study will use just the score of anxiety.

Blood and Lymph Conditions

Immune System Diseases

Rare Diseases

Leukemia

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Leukemia, Lymphoid

Lymphoma

Neoplasms by Histologic Type

Hematologic Diseases

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Acute Lymphoblastic Leukemia

Lymphoblastic Lymphoma

Lymphosarcoma

osteopathy

Benoit BRETHON, MD

Laurent STUBBE, MD

During the curative treatment of cancer, pain often remains the dominant symptom affecting the physical and psychological state of the patient.

Osteopathy is an exclusively manual practice whose goal is to compensate for mobility dysfunctions of the tissues of the human body. It can be used as a complementary treatment for cancer pain when pain medications are not enough.

The aim of this study is to examine the effectiveness of osteopathy in reducing pain intensity and improving quality of life in patients treated for pediatric acute lymphoblastic leukemia.

During the curative treatment of cancer, pain often remains the dominant symptom affecting the physical and psychological state of the patient.

Osteopathy is an exclusively manual practice whose goal is to compensate for mobility dysfunctions of the tissues of the human body. It can be used as a complementary treatment for cancer pain when pain medications are not enough.

The aim of this study is to examine the effectiveness of osteopathy in reducing pain intensity and improving quality of life in patients treated for pediatric acute lymphoblastic leukemia.

Primary objective :

To evaluate the effectiveness of five osteopathy sessions at regular intervals on the characteristics of the pain felt in patients aged 1 to 10 years treated for acute lymphoblastic leukemia using the HEDEN scale (Hetero-Evaluation Pain Child).

Efficacy of Osteopathic Treatment on the Side Effects of Curative Treatments of Lymphoblastic Leukemia in Pediatrics

HEDEN (Hetero-Evaluation Pain Child) score before and after each intervention

FPS-R (Face Pain Scale-Revised) score before and after each osteopathy session

PedsQL™ Questionnaire quality of life in paediatrics

Assistance Publique - Hôpitaux de Paris

Once their clinical data were collected and their symptoms were assessed, all the enrolled patients had an osteopathic session a week during two weeks. After those sessions, they had an interview (scheduled between D11 and D14) with a psychologist

Ostheopathic treatment

For more than seven years an osteopath has been working in the palliative care unit (PCU) and in both palliative care mobile team (PCMT) as a member of the multidisciplinary team. The patients referred to the osteopath by the palliative care physicians present pains related to cancer, but also to the treatment, in particular to surgery or radiotherapy. The osteopath can help with other symptoms such as constipation or dyspnoea. As this approach is provided in complement of the medicinal approach, it is not considered as an alternative medicine but as a complementary medicine associated to a conventional care. It seemed relevant to the investigators to ask the cancer patients undergoing osteopathic sessions for pain how they saw this complementary therapy.

Cancer Patient Perceptions of the Osteopathy Treatment: a Qualitative Study

Once clinical data were collected and symptoms were assessed, all the enrolled patients had an osteopathic session a week during two weeks. After those sessions, they had an interview (scheduled between J11 and J14) with a psychologist. The research assistant psychologist conducted the semi-directed interviews. The interview questions were geared toward eliciting open-ended responses to acquire specific information about the patient thoughts and emotions associated with osteopathic treatment. In our study, we conducted two preliminary interviews to test the quality of the questions we planned to use with the participants. The specific questions that were used during the interview are available on request from the authors.

Neuralgia

Peripheral Nervous System Diseases

Neuromuscular Diseases

Dermatologic Agents

All Drugs and Chemicals

Capsaicin

Osteopathic treatment, 3 sessions of 1h + Treatment As Usual (TAU)

Treatment As Usual, Capsaicin Qutenza Patch (Conventionnal Treatment in algology in supportive care)

Capsaicin QUTENZA Patch is the treatment as usual (TAU) delivered in the medical algology service

Capsaicin QUTENZA Patch (TAU)

Marie Bourguoin, MD

Loïc TREFFEL, PhD

The aim of the study is to evaluate the Impact of add-on osteopathic treatment in the algological course of patients treated for breast cancer : Randomized Controlled Trial.

Background: In women, the breast is the most common cancer site in the world and is unfortunately the one with the highest number of deaths. It is estimated that 30-50% of women who have undergone a mastectomy are affected by this post-operative syndrome and that 50% of patients would report chronic pain one year after surgery. Chronic pain after breast surgery (incidence of 30% at 3 months) has an essentially neuropathic component. There are many contributing factors, depending on the surgery, the patient, the analgesia technique and the treatments associated with the cancer.

Methods: The ALGOS study has received a favourable opinion from the Ethical Committee (CPP). Capsaicin patch (Qutenza 179mg) treatment as usual (TAU) is delivered in medical algological care in Oncopole, Toulouse, France. In total 120 patients meeting the inclusion criteria will be randomly assigned to one of the 3 treatment groups: One receiving osteopathic treatment before the TAU (Group 1) ; The second group receiving the OT in addition to and during the TAU (Group 2) ; The third group will receive OT after the TAU and if considered in "therapeutic failure" (Group 3). Each group will have his own control (G1C-G2C-G3C). All the patients in group 1,2,3 will receive 3 1-hour osteopathic treatment sessions in a "backbox" strategy of treatment.

The TAU by Qutenza is defined and recommended by the French health high authority. The primary outcome is the evaluation of neuropathic pain by DN4 score. The secondary outcomes include superficial fascial tissue properties of the scar by MyotonPRO, the therapeutic alliance quality will be evaluated by the Working Alliance Inventory (WAI) and the impact of pain in their quality of life by the Brief Pain Inventory (BPI score).

Discussion: If the results of the ALGOS study are positive, the study will provide arguments in favor of osteopathic treatment as a possible non-invasive additional treatment option in the multidisciplinary care support approach for patients with neuropathic pain after a breast cancer.

Trial Registration: Date: Release December-09, 2022 (positive opinion from ethical committee CPP) /N° ID-RCB: 2022-A01349-34.

Algology in Oncology Osteopathic Support (ALGOS)

Algology in Oncology Osteopathic Support

Score to evaluate the quality of therapeutic alliance / 36 questions each item is scored from 1 (minimum) to 7 (maximum) / Global score on 252 / Higher scores reflects a more positive rating of working alliance

Neuropathic pain assessment in 4 points (DN4 questionnaire) 10 questions / A result more than 4/10 means a neuropathic pain component. 0 = minimum 10 = maximum

Impact of pain in the quality of life (Brief Pain Inventory Score) / 9 questions with scales 0 to 10, where 0 = No pain and 10 = Maximal pain or impact

Mechanical Fascial tissue properties evaluated by MyotonPRO device (Validity/reliability confirmed in scientific research). This is a Non invasive device. A standardized force ( 0.48N) applied on the superficial skin to study the mechanical oscillation in response of the deformation. Variables measured are the Tone (Hz), Stiffness (N/m), Logaryhmic decrement, Relaxation time (ms). All these parameters traduce the "state of tone -elasticity" of the fascial tissue. (Higher is the stiffness value higher is the state of tone. Lower is the value lower is the tension).

Institut Claudius Regaud

Institut Toulousain d'Ostéopathie

Respiratory Tract (Lung and Bronchial) Diseases

Heart and Blood Diseases

Lung Neoplasms

Multiple Myeloma

Neoplasms, Plasma Cell

Hemostatic Disorders

Blood Coagulation Disorders

Vascular Diseases

Paraproteinemias

Blood Protein Disorders

Hemorrhagic Disorders

Patients will receive only caner treatment. No osteopathic treatment.

Patients will receive cancer treatment associated with osteopathic intervention

Osteopathic intervention

CRP assessment

QLQ-C30 questionnaire

Borhane SLAMA, MD

In France, new cancer cases keep on increasing with around 150 000 deaths yearly. Cancer therapy research is constantly evolving. Indeed, several studies explore new treatments or their combination with conventional cancer treatments. But, at the same time, complementary and alternative medicines, as osteopathy, remain little explored upon their role in the combination with conventional therapy.

Several studies showed indirect interaction between vagus nerve and cancer. Firstly, vagus nerve regulates homeostasis and immunity by reducing systemic inflammation while maintaining local inflammation and antitumor effects. Secondly, vagus nerve stimulation increases Heart Rate Variability (HRV). Moreover, a higher HRV is associated with an improvement of vital prognosis in cancer patients. Vagus nerve could be stimulated by noninvasive osteopathic manipulations.

This prospective, monocentric and randomized study is a collaboration between the Centre Hospitalier d'Avignon and the Institut de Formation en Ostéopathie du Grand Avignon. It focuses on using noninvasive osteopathic mobilizations to stimulate vagus nerve. Indeed, this study aims to evaluate effects of vagus nerve osteopathic stimulations on HRV in patients with lung cancer, colorectal cancer, Non Hodgkin Lymphoma or Multiple Myeloma. More specifically, this study will tell us whether vagus nerve noninvasive osteopathic stimulations induce increase of HRV associated with a decrease of systemic inflammation and an improvement of patient's quality of life.

For each cancer type, 30 patients will be included. These patients will be randomized into two groups.

Heart Rate Variability, Vagus Nerve and Cancer

Effects of Vagus Nerve Osteopathic Stimulations on Heart Rate Variability of Cancer Patients

To assess the effect of vagus nerve osteopathic stimulations on Heart Rate Variability

To assess the effect of vagus nerve osteopathic stimulations on systemic inflammatory

To assess the effect of vagus nerve osteopathic stimulations on health related quality of life

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Osteopathy Treatment for Cancer Pain Related to the Confinement to Bed	NCT03440957	Cancer Patient ...	Osteopathic tre...	18 Years -	Hospices Civils de Lyon
Impact of Osteopathy on Pain After Breast Cancer Surgery	NCT02621437	Breast Cancer	Osteopathy sess... phone questionn...	18 Years -	Hospices Civils de Lyon
Efficacy of Osteopathic Treatment on the Side Effects of Curative Treatments of Lymphoblastic Leukemia in Pediatrics	NCT05664230	Lymphoblastic L...	osteopathy	1 Year - 10 Years	Assistance Publique - Hôpitaux de Paris
Cancer Patient Perceptions of the Osteopathy Treatment: a Qualitative Study	NCT02627638	Cancer Patients	Ostheopathic tr...	18 Years -	Hospices Civils de Lyon
Impact of Osteopathy on Pain After Breast Cancer Surgery	NCT02621437	Breast Cancer	Osteopathy sess... phone questionn...	18 Years -	Hospices Civils de Lyon
Cancer Patient Perceptions of the Osteopathy Treatment: a Qualitative Study	NCT02627638	Cancer Patients	Ostheopathic tr...	18 Years -	Hospices Civils de Lyon
Efficacy of Osteopathic Treatment on the Side Effects of Curative Treatments of Lymphoblastic Leukemia in Pediatrics	NCT05664230	Lymphoblastic L...	osteopathy	1 Year - 10 Years	Assistance Publique - Hôpitaux de Paris
Algology in Oncology Osteopathic Support (ALGOS)	NCT05726929	Breast Cancer Neuropathic Pai...	Osteopathic tre... Capsaicin QUTEN...	18 Years - 80 Years	Institut Toulousain d'Ostéopathie
Osteopathy Treatment for Cancer Pain Related to the Confinement to Bed	NCT03440957	Cancer Patient ...	Osteopathic tre...	18 Years -	Hospices Civils de Lyon
Algology in Oncology Osteopathic Support (ALGOS)	NCT05726929	Breast Cancer Neuropathic Pai...	Osteopathic tre... Capsaicin QUTEN...	18 Years - 80 Years	Institut Toulousain d'Ostéopathie
Cancer Patient Perceptions of the Osteopathy Treatment: a Qualitative Study	NCT02627638	Cancer Patients	Ostheopathic tr...	18 Years -	Hospices Civils de Lyon
Heart Rate Variability, Vagus Nerve and Cancer	NCT04718610	Lung Cancer Colorectal Canc... Multiple Myelom... Non Hodgkin Lym...	Osteopathic int... CRP assessment QLQ-C30 questio...	18 Years -	Centre Hospitalier Henri Duffaut - Avignon

Spots Global Cancer Trial Database for osteopathy

Every month we try and update this database with for osteopathy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for osteopathy

Every month we try and update this database with for osteopathy cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for osteopathy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.