Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Symptoms and General Pathology

Rare Diseases

Carcinoma

Ovarian Neoplasms

Sarcoma

Uterine Cervical Neoplasms

Endometriosis

Cysts

Ovarian Cysts

Adenomyosis

Endometrial Neoplasms

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Pathological Conditions, Anatomical

Ovarian Diseases

Adnexal Diseases

Gonadal Disorders

Endocrine System Diseases

Endocrine Gland Neoplasms

Ovarian Cancer

Soft Tissue Sarcoma

Uterine Sarcoma

Patients will be intravenously injected ICG (Yichuang Pharmaceutical Limited Liability Company, Dandong, China) at a dose of 2-5 mg per kg of body weight before surgery or 0.25-0.5 mg per kg of body weight during surgery. Then, a NIR imaging systems included the NIR (800-900 nm) and white-light (400-650nm) dual-channel will be used to detect In situ lesions, metastatic lesions, lymph nodes, obturator nerve, pelvic autonomic nerve, etc during surgery according to disease and clinical needs.

Patients will be intravenously injected ICG (Yichuang Pharmaceutical Limited Liability Company, Dandong, China) at a dose of 2-5 mg per kg of body weight before surgery or 0.25-0.5 mg per kg of body weight during surgery. Then real-time near-infrared imaging will be conducted during surgery.

Intravenous ICG and Real-Time Near-infrared Imaging

Chunlin Chen, MD/PhD

chunlin chen, MD/PhD

Removing in situ and metastasis lesions completely during gynecological surgery is central to reduce the recurrence and death, and the identification of lesions in traditional gynecological surgery often depends on the experience of surgeons. The identification of nerves is often needed in gynecological surgery, such as the obturator nerves in pelvic lymphadenectomy, and the pelvic autonomic nerves in nerve-sparing radical hysterectomy for cervical cancer. Nerve identification also relies heavily on the experience of surgeons. This project aims to realize the identification of lesions and nerves under the navigation of indocyanine green fluorescent imaging, and evaluate the accuracy of fluorescent imaging of lesions and the effectiveness of nerves identification by near-infrared imaging. This project may reduce the recurrence or death caused by residual lesions and postoperative dysfunction caused by nerves injury, thus, improve the survival rate and quality of life for patients with gynecological diseases.

The Application of Real-Time Near-infrared Imaging in Gynecological Surgery

Real-Time Identification of Lesions and Nerves by Using Indocyanine Green Fluorescent Imaging in Gynecological Surgery

Evaluation of the effectiveness of real-time near-infrared imaging in detecting the margin of in situ lesions, whether there is metastasis lesions and whether the metastasis lesions has been completely removed , lymph node metastasis or not during gynecological surgery. The criteria of evaluation is postoperative pathological results and fluorescence intensity of specimen sections measured by laser scanning confocal microscope.

Evaluation of the effectiveness of real-time near-infrared imaging in detecting nerves associated with gynecological surgery, including the pelvic autonomic nerves composed of the abdominal aortic plexus, the superior hypogastric plexus, the hypogastric nerves, the pelvic splanchnic nerves, the inferior hypogastric plexus and its branches, obturator nerves, genitofemoral nerve, etc.

Chinese Academy of Sciences

Chen Chunlin

Department of Obstetrics and Gynecology

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Application of Real-Time Near-infrared Imaging in Gynecological Surgery	NCT04224467	Cervical Cancer Ovarian Tumor Endometrial Car... Uterine Myomato... Adenomyosis Ovarian Cyst Be... Ovarian Cyst Ma... Endometriosis Uterine Sarcoma	Intravenous ICG...	18 Years - 80 Years	Southern Medical University, China
The Application of Real-Time Near-infrared Imaging in Gynecological Surgery	NCT04224467	Cervical Cancer Ovarian Tumor Endometrial Car... Uterine Myomato... Adenomyosis Ovarian Cyst Be... Ovarian Cyst Ma... Endometriosis Uterine Sarcoma	Intravenous ICG...	18 Years - 80 Years	Southern Medical University, China

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