Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Endometrial Neoplasms

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Endometrial cancer radical surgery to be administered in this arm.

Fertility-sparing surgery to be administered in this arm.

Ovarian preservation surgery to be administered in this arm.

Take hysterectomy and bilateral adnexectomy.

endometrial cancer radical surgery

Take endometrectomy , preserve uterus and bilateral ovaries.

fertility-sparing surgery

Take hysterectomy,preserve bilateral ovaries.

ovarian preservation surgery

Min Wang, PHD.

YiSi Liu

Min Wang, PHD

Through multicenter, prospective, randomized, controlled clinical studies comparing different treatment options (fertility-sparing surgery and ovarian preservation surgery and radical surgery)therapeutic efficacy, safety and quality of life of patients, exploration of the best strategies and risks for the treatment of early endometrial cancer, and promotion and application.

Patients eligible for enrollment are selected and divided into three groups randomly, including fertility group,ovarian preservation group and endometrial cancer radical surgery group. Take interventions including fertility preservation surgery,ovarian preservation surgery and endometrial cancer radical surgery for patients in different groups respectively. Compare therapeutic efficacy, safety and quality of life of patients to evaluate three treatment and explore the best treatment for clinical application.

The Multicentic Trial in Fertility-sparing Treatment and Ovarian Preservation Management for Early Endometrial Cancer

The Randomized Multicentic Prospective Controlled Trial in Fertility-sparing Treatment and Ovarian Preservation Management for Early Endometrial Cancer

calculate the time from patients enter the group to death

measure the ovarian volume dynamically by ultrasonography

measure the endocrine function(hormone level) dynamically by blood detection

calculate the time from patients enter the group to tumor progression

First Hospital of China Medical University

Min Wang

Director

Participants will be undergoing surgery for clinical stage I endometrioid endometrial cancer

The IES-R is a validated 22-item self-report scale measuring psychological stress reactions after a major life or traumatic event.1-3Items are rated with reference to the past 7 days on a 5-point scale, ranging from 0 to 4. Three subscale scores are calculated by taking the mean of the item responses: Intrustion (8 items), Avoidance (8 items), and Hyperarousal (6 items). The total score is similarly computed by taking the mean of all 22 items. All scores range from 0 to 4, with higher scores indicating higher event-related distress. Internal consistency estimates(Cronbach's alpha) for all scores range between 0.79 to 0.92.

Impact of Event Scale-Revised

The RCS is a 14-item, 5-point Likert-type self-report measure that assesses concern among cancer survivors whose reproductive ability may have been impaired or lost due to disease and/or treatment. Answers are rated on a 5-point scale (0 to 4), and a single total score is produced by summing responses to all 14 items (range, 0-56 points). A higher score represents more reproductive concerns, and a lower score represents fewer reproductive concerns. In the RCS validation study, internal consistency reliability was 0.91 among long-term female cancer survivors and 0.81 among control women.

Reproductive Concerns Scale

The DRS is a 5-item, 5-point Likert-type self-report measure that assesses distress or remorse after a health-care decision.5 Items are rated on a scale from 1 ("strongly agree") to 5 ("strongly disagree"). Two of the statements (items 2 and 4) are phrased in the negative direction.

A single, total score is produced by first reversing the scores of the 2 negatively phrased items, then taking the mean of the 5 items. This mean is then rescaled to range from 0 to 100 by subtracting 1, then multiplying by 25. A score of 0 indicates no regret, whereas a score of 100 indicates high regret. Internal consistency reliability coefficients for the DRS range from 0.81 to 0.92.

Decision Regret Scale

Jennifer Mueller, MD

Nadeem Abu-Rustum, MD

Charles Rutter, MD

The purpose of this study is to learn more about the factors that influence decision-making before surgery (distress about cancer and/or reproductive concerns) and the possibility of regret after surgery.

Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer

Preservation of Ovaries in Endometrial Malignancies: GYN POEM Trial

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

Examine the decision-making process of patients who choose to undergo or not undergo ovarian-sparing surgical treatment of endometrial cancer to identify influencing factors-in particular, cancer-related psychological distress and reproductive concerns-and any potential decisional regrets following surgical intervention.

Memorial Sloan Kettering Cancer Center

Carcinoma

endometrial cancer with ovarian preservation

endometrial cancer without ovarian preservation

endometrial cancer with or without oophorectomy

surgery

Yi-Jen Chen, MD

Yi-Jen Chen, PHD

Yi-Jen Chen

Endometrial cancer is one of the most common female malignancies in the United States, and has increased in incidence in Taiwan in recent decades.A recent population-based analysis noted that 4% of endometrial cancers occurred in women aged 40 years or younger, furthermore it is up to 15% in Taiwan according to the data of cancer registry. The standard treatment of endometrial cancer results in surgical menopause and places patients at risk for the long-term sequelae of estrogen deprivation. The goal of this study was to determine the frequency of a coexisting ovarian malignancy and to evaluate the outcome of ovarian preservation in women with treatment for endometrial cancer.

we reviewed the cases with early stage of endometrial cancer who have primary staging surgery between January 1989 to December 2009. The enrolled patients will be divided into two group (oophorectomy vs. ovary preservation) for analysis:the outcome and recurrence type.To evaluate the outcome of ovarian preservation in women with endometrial cancer .

Retrospective Study to Evaluate the Feasibility of Ovarian Preservation in Patients With Endometrial Carcinoma

Study for Elevate the Feasibility of Ovarian Preservation With Endometrial Carcinoma

the time of diagnosis to the time of disease recurrence or last follow time

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Multicentic Trial in Fertility-sparing Treatment and Ovarian Preservation Management for Early Endometrial Cancer	NCT03804463	Endometrial Can...	endometrial can... fertility-spari... ovarian preserv...	21 Years - 65 Years	Shengjing Hospital
Choosing Ovarian Preservation or Removal Before Surgery for Endometrial Cancer	NCT04569773	Endometrial Can...	Impact of Event... Reproductive Co... Decision Regret...	18 Years - 50 Years	Memorial Sloan Kettering Cancer Center
The Multicentic Trial in Fertility-sparing Treatment and Ovarian Preservation Management for Early Endometrial Cancer	NCT03804463	Endometrial Can...	endometrial can... fertility-spari... ovarian preserv...	21 Years - 65 Years	Shengjing Hospital
Retrospective Study to Evaluate the Feasibility of Ovarian Preservation in Patients With Endometrial Carcinoma	NCT01560026	Endometrial Can...	surgery	25 Years - 70 Years	Taipei Veterans General Hospital, Taiwan

Spots Global Cancer Trial Database for ovarian preservation