Neoplasms

All Conditions

Symptoms and General Pathology

Carcinoma

Carcinoma, Squamous Cell

Hypoxia

Head and Neck Neoplasms

Squamous Cell Carcinoma of Head and Neck

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

5 non-patient volunteers for testing of protocol to allow for the ascertaining of good quality data prior to the scanning of patients.

50 patients to be scanned with the oxygen enhanced MRI scan protocol prior to definitive curative intent therapy.

Dynamic MRI scanning switching from breathing room air to high concentration oxygen part way through the scan.

Oxygen Enhanced MRI scan

Rafal Panek, PhD

Assessment of the use of oxygen enhanced MRI scanning in a cohort of patients with head and neck squamous cell carcinomas to identify areas of hypoxia with tumours and relate this to treatment outcomes.

Oxygen-enhanced MRI (OE-MRI) is a technique being actively investigated for imaging hypoxia within cancer tissues. Preliminary clinical data demonstrates the feasibility of using this methodology to study patients with head and neck squamous cell carcinoma (HNSCC). The investigators wish to investigate using this methodology to identify hypoxic subvolumes within HNSCC that may have greater resistance to standard radiotherapy treatment and investigate the association of such hypoxic regions with treatment outcomes.

Evaluation of OE-MRI in Patients With H&N Cancer

Evaluation of Oxygen Enhanced Magnetic Resonance Imaging for Identification of Hypoxia Induced Resistant Tumours in Patients With Head and Neck Cancer

Feasibility of OE-MRI scans to detect hypoxic areas within tumours in patients with head and neck squamous cell carcinomas

Test predictive value of OE-MRI to identify patients with the highest risk of treatment failure and provide data to allow a power calculation for a larger future trial of the predictive power of OE-MRI for treatment outcomes in head and neck cancer treated with radiotherapy.

Assessment of routinely used diagnostic MRI images to identify non-perfused parts of tumours in combination with oxygen maps

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Evaluation of OE-MRI in Patients With H&N Cancer	NCT04724096	Head and Neck S...	Oxygen Enhanced...	18 Years - 99 Years	Nottingham University Hospitals NHS Trust
Evaluation of OE-MRI in Patients With H&N Cancer	NCT04724096	Head and Neck S...	Oxygen Enhanced...	18 Years - 99 Years	Nottingham University Hospitals NHS Trust

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