Infections

All Conditions

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Neoplasms

Rare Diseases

Communicable Diseases

Papillomavirus Infections

Carcinoma

Carcinoma in Situ

Uterine Cervical Dysplasia

Disease Attributes

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Precancerous Conditions

Uterine Cervical Diseases

Uterine Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Sexually Transmitted Diseases

Sexually Transmitted Diseases, Viral

Virus Diseases

DNA Virus Infections

Tumor Virus Infections

Cervical Intraepithelial Neoplasia

Aminolaevulinic acid (500-mg bottle)

Aminolaevulinic acid (750-mg bottle)

Placebo

Efficacy and Safety of ALA-PDT in patients with cervical intraepithelial neoplasia grade 2 (CIN2) in p16-positivity and high-risk HPV infection.

A multi-center, randomized, double-blind, placebo-controlled phase IIc clinical trial of ALA-PDT in patients with cervical intraepithelial neoplasia grade 2 (CIN2) in p16-positivity and high-risk HPV infection.

ALA-PDT in Patients With CIN2 in p16-positivity and High-risk HPV Infection

A Multi-center, Randomized, Double-blind, Placebo-controlled Phase IIc Clinical Trial of ALA-PDT in Patients With Cervical Intraepithelial Neoplasia Grade 2 (CIN2) in p16-positivity and High-risk HPV Infection

"Response" is defined as: pathology showed normal or only inflammatory changes or CIN1

"Cure" is defined as: pathology showed normal or only inflammatory changes

Proportion of patients with HPV clearance

Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.

Uterine Cervical Neoplasms

Uterine Neoplasms

Genital Neoplasms, Female

Urogenital Neoplasms

All eligible participants as one group accept P16INK4A testing, with cytology and/or hrHPV assay.

P16INK4A immunohistochemical staining is to be performed in residual cytology samples.

p16 protein expression

Lei Li, M.D.

Ming Wu, M.D.

Lei Li, MD

Cyclin kinase inhibitor P16INK4A has overexpression in cervical cancer, and hence becoming an alternative method for cervical cancer screening. This study is to investigate the clinical value of P16INK4A and high-risk human papillomavirus (hrHPV) detection of cervical intraepithelial neoplasia (CIN) 2 or more severe lesions (CIN2+). All eligible participants accept P16INK4A testing, with cytology and/or hrHPV assay. P16INK4A immunohistochemical staining is performed on the retained specimens of cytology. The primary endpoint is the diagnostic accuracy of P16INK4A compared with cytology and/or hrHPV status based on histology results. The accuracy analysis includes sensitivity, specificity, negative predictive value and positive predictive value.

All eligible participants as a cohort, accept P16INK4A testing, with cytology and/or hrHPV assay

Immunohistochemical Staining of p16 for the Screening of Cervical Cancer

Diagnostic accuracy of p16 protein expression for detecting cervical intraepithelial neoplasia (CIN) 2 or more severe lesions (CIN2+)

Lei Li

Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
ALA-PDT in Patients With CIN2 in p16-positivity and High-risk HPV Infection	NCT06439433	Cervical Intrae... Papillomavirus ... p16 Protein	Aminolaevulinic... Aminolaevulinic... Placebo	18 Years - 45 Years	Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Immunohistochemical Staining of p16 for the Screening of Cervical Cancer	NCT04650711	Cervical Cancer... p16 Protein Cytology High-risk Human... Diagnostic Accu... Histology Cervical Intrae...	p16 protein exp...	21 Years -	Peking Union Medical College Hospital
ALA-PDT in Patients With CIN2 in p16-positivity and High-risk HPV Infection	NCT06439433	Cervical Intrae... Papillomavirus ... p16 Protein	Aminolaevulinic... Aminolaevulinic... Placebo	18 Years - 45 Years	Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.

Spots Global Cancer Trial Database for p16 protein

Every month we try and update this database with for p16 protein cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for p16 protein

Every month we try and update this database with for p16 protein cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for p16 protein cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.