Symptoms and General Pathology

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Nervous System Diseases

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Mouth and Tooth Diseases

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Asthenia

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Facies

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Parotid Neoplasms

Disease Attributes

Neurologic Manifestations

Salivary Gland Neoplasms

Mouth Neoplasms

Head and Neck Neoplasms

Mouth Diseases

Stomatognathic Diseases

Parotid Diseases

Salivary Gland Diseases

Oral Cancer

As for deep seated tumors in preoperative CT or US (or tumors in both superficial and deep parotid glands), the patients will undergo surgery without 3D-DESS MRI (currently routine practice).

As for deep seated tumors in preoperative CT or US (or tumors in both superficial and deep parotid glands), preoperative 3D-DESS MRI will be additionally performed to delineate the intra-parotid facial nerve.

3D-DESS MRI has been reported useful for the intra-parotid facial nerve imaging. It can provide information about the anatomical relationship between the tumor and the facial nerve in the parotid gland.

3D-DESS MRI (3 dimensional double echo steady state MRI)

Han-Sin Jeong, MD

In this study, the investigators will evaluate the clinical usefulness of 3 dimensional double echo steady state MRI (3D-DESS MRI) for functional preservation of the facial nerve during parotidectomy. Preoperative 3D-DESS MRI imaging can provide information about the anatomical relationship between the tumor and the facial nerve in the parotid gland.

Because the risk of postoperative facial weakness is relatively high in the deep-seated parotid tumors, the investigators will exclude the patients with the superficial parotid tumors (determined by preoperative CT or US) and only include the patients with deep seated parotid tumors in this trial.

The main outcome of our study is the incidence of immediate postoperative facial weakness, and the secondary outcome is the incidence of facial weakness at postoperative 6 months.

Surgical removal of tumors arising from the parotid gland (benign or malignant) is treatment of choice. However, the most detrimental complication of parotidectomy is facial weakness or facial nerve palsy, because the facial nerve crosses in the mid-portion of the parotid gland.

Numerous studies indicated the incidence of temporary facial weakness as 5-45% and permanent facial palsy as 0-15% after parotidectomy. To reduce this complication, the investigators will apply the modern technique of MRI imaging to inform the anatomical relationship between the tumor and the facial nerve within the parotid gland preoperatively. Three dimensional double echo steady state MRI imaging (3D-DESS MRI) has been reported useful for the intra-parotid facial nerve imaging.

Thus, the investigators will evaluate the clinical usefulness of 3D-DESS MRI for functional preservation of the facial nerve during parotidectomy. Preoperative 3D-DESS MRI imaging can provide information about the anatomical relationship between the tumor and the facial nerve in the parotid gland.

In the retrospective series, the investigators found that there were 25.6% temporary facial weakness and 10.3% permanent (\> 6 months) facial weakness after parotidectomy for deep-seated parotid tumors (plus tumors located in both deep and superficial parotid gland); whereas 6.7% and 3.6% facial weakness respectively for superficially located parotid tumors. Because the risk of postoperative facial weakness is relatively high in the deep-seated parotid tumors, the investigators will exclude the patients with the superficial parotid tumors (determined by preoperative CT or US) and only include the patients with deep seated parotid tumors in this trial.

The main outcome of our study is the incidence of immediate postoperative facial weakness, and the secondary outcome is the incidence of facial weakness at postoperative 6 months.

Intra-parotid Facial Nerve Imaging in Parotidectomy

Postoperative Facial Weakness in Parotidectomy for Deep Seated Parotid Tumor With or Without Intra-parotid Facial Nerve Imaging (3D Double-Echo Steady-State With Water Excitation MRI Imaging)

The investigators will make our participant data available to other researchers after completion of this study.

Evaluation of facial function using Facial palsy grading system, immediately after parotidectomy.

Measures: House-Brackmann Facial Nerve Grading System (1: Normal, 2: Mild dysfunction, 3: Moderately dysfunction, 4: Moderately severe dysfunction, 5: Severe dysfunction, 6: Total paralysis)

Evaluation of facial function using Facial palsy grading system, at 6 months after parotidectomy.

Measures: House-Brackmann Facial Nerve Grading System (1: Normal, 2: Mild dysfunction, 3: Moderately dysfunction, 4: Moderately severe dysfunction, 5: Severe dysfunction, 6: Total paralysis)

Samsung Medical Center

Professor

Infections

Postoperative Complications

Bell Palsy

Facial Paralysis

Paralysis

Bell's Palsy

Pei-Jen Lou, MD, Ph.D

The aim of this study was to determine the histopathological results of parotid tumors and postoperative complications after partial superficial or total parotidectomy with facial nerve dissection and superficial musculoaponeurotic system reconstruction.

Retrospective Clinical Outcome of Parotid Tumor Surgery

Record the grade of facial palsy in patients receiving the surgery of parotid tumor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Intra-parotid Facial Nerve Imaging in Parotidectomy	NCT03822728	Parotid Tumors Facial Nerve Pa...	3D-DESS MRI (3 ...	18 Years - 70 Years	Samsung Medical Center
Retrospective Clinical Outcome of Parotid Tumor Surgery	NCT01983176	Parotid Tumors Postoperative C...		10 Years - 84 Years	National Taiwan University Hospital
Intra-parotid Facial Nerve Imaging in Parotidectomy	NCT03822728	Parotid Tumors Facial Nerve Pa...	3D-DESS MRI (3 ...	18 Years - 70 Years	Samsung Medical Center

Spots Global Cancer Trial Database for parotid tumors