Urinary Tract, Sexual Organs, and Pregnancy Conditions

Symptoms and General Pathology

All Conditions

Proteinuria

Urination Disorders

Urologic Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Male Urogenital Diseases

Urological Manifestations

Antineoplastic Agents

All Drugs and Chemicals

Bevacizumab

Taken biological samples (urine and blood) and blood pressure measurement on patients starting bevacizumab treatment for cancer

Biological samples

Home blood pressure self-measurement and hospital blood pressure measurement

Blood pressure measurement

Theodora BEJAN-ANGOULVANT, MD-PhD

Bevacizumab is an anti-angiogenic treatment used to treat various solid cancers. Previous studies have shown that this treatment may have adverse effects like hypertension and proteinuria.

This is an exploratory study aiming to better understand the relationship between various biomarkers and blood pressure changes and proteinuria measured for 4 to 6 weeks after the first infusion of anti-VEGF therapy with bevacizumab.

Participants will be invited to participate to this research study by their oncologist within 1 to 2 weeks before starting bevacizumab treatment, as part of standard treatment. They will finish the research at the end of the third infusion of bevacizumab.

Patients will perform a home blood pressure self-measurement over three days and will collect urine over 24 hours prior to the start of each bevacizumab infusion at cycles 1, 2 and 3. Blood pressure measurements will also be performed during each bevacizumab infusion and blood tests will be performed before each infusion to measure the following biomarkers:

* Salt consumption as estimated by 24-hour natriuresis measured before each of the first 3 infusions
* 24 hours aldosterone excretion measured before the first and third infusions
* plasma methoxylated derivatives measured before the first and third infusions
* NTproBNP measured before the first and third infusions
* 24 hours urinary free cortisol measured before the first and third infusions
* bevacizumab trough concentration measured before the first three bevacizumab infusion

urine and blood samples will be drawn to measure proteinuria and concentration of various biomarkers (as listed above)

SAlt Diet and Various Biomarkers Effects on Blood Pressure and Proteinuria During Inhibition of VEGF)

Home blood pressure (systolic, diastolic) before each bevacizumab infusion, as the mean of 3 measures in the morning and 3 measures in the evening, over 3 days

Standardized measurement of in-hospital blood pressure (systolic, diastolic) and heart rate during bevacizumab infusion

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
SAlt Diet and Various Biomarkers Effects on Blood Pressure and Proteinuria During Inhibition of VEGF)	NCT03842917	Patient Startin... Cancer	Biological samp... Blood pressure ...	18 Years -	University Hospital, Tours
SAlt Diet and Various Biomarkers Effects on Blood Pressure and Proteinuria During Inhibition of VEGF)	NCT03842917	Patient Startin... Cancer	Biological samp... Blood pressure ...	18 Years -	University Hospital, Tours

Spots Global Cancer Trial Database for patient starting bevacizumab