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Antineoplastic Agents

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Irinotecan

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Folfirinox

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Neoadjuvant chemotherapy 4 courses of FIRINOX early 5 patients, and 8 courses of FIRINOX subsequent 5 patients

FIRINOX regimen by eliminating LV and bolus 5-FU, and irinotecan reduced to 150mg/m2 of 180mg/m2 from FOLFIRINOX regimen.

FIRINOX

Hiroki Yamaue, M.D., PhD

FOLFIRINOX regimen was recently presented at an international oncology meeting and represents a new standard regimen in the treatment of metastatic pancreatic cancer. FOLFIRINOX is one of the high response rate treatment regimen , the investigators considered as a promising treatment as neoadjuvant chemotherapy . On the other hand , incidences of grade 3 or 4 neutropenia , febrile neutropenia and diarrhea were significantly higher in the FOLFIRINOX group compared with gemcitabine group. Therefore, it was decided to consider the balance of safety and efficacy as a preoperative chemotherapy, the investigators use the FIRINOX regimen by eliminating LV and bolus 5-FU, and irinotecan reduced to 150mg/m2 of 180mg/m2 from FOLFIRINOX regimen

FOLFIRINOX regimen was recently presented at an international oncology meeting and represents a new standard regimen in the treatment of metastatic pancreatic cancer. FOLFIRINOX is one of the high response rate treatment regimen , the investigators considered as a promising treatment as neoadjuvant chemotherapy . On the other hand , incidences of grade 3 or 4 neutropenia , febrile neutropenia and diarrhea were significantly higher in the FOLFIRINOX group compared with gemcitabine group. Therefore, it was decided to consider the balance of safety and efficacy as a preoperative chemotherapy, the investigators use the FIRINOX regimen by eliminating LV and bolus 5-FU, and irinotecan reduced to 150mg/m2 of 180mg/m2 from FOLFIRINOX regimen. The investigators also evaluate the optimal treatment schedule of FIRINOX therapy as neoadjuvant chemotherapy, optimal duration between surgery and chemotherapy, R0 resection rate, and resection rate for borderline resectable pancreatic cancer.

Neoadjuvant FIRINOX for Borderline Resectable Pancreatic Cancer - a Pilot Study

The Pilot Study of Neoadjuvant Chemotherapy of FIRINOX for Patients With Borderline Resectable Pancreatic Cancer

Toxicities will be assessed according to Common Terminology Criteria for Adverse Events (CTCAE) 4.0.

Wakayama Medical University

Dean & Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Neoadjuvant FIRINOX for Borderline Resectable Pancreatic Cancer - a Pilot Study	NCT02148549	Patients With B...	FIRINOX	20 Years - 74 Years	Wakayama Medical University
Neoadjuvant FIRINOX for Borderline Resectable Pancreatic Cancer - a Pilot Study	NCT02148549	Patients With B...	FIRINOX	20 Years - 74 Years	Wakayama Medical University

Spots Global Cancer Trial Database for patients with borderline resectable pancreatic cancer