Neoplasms

Heart and Blood Diseases

Blood and Lymph Conditions

Immune System Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Multiple Myeloma

Neoplasms, Plasma Cell

Smoldering Multiple Myeloma

Neoplasms by Histologic Type

Hemostatic Disorders

Blood Coagulation Disorders

Vascular Diseases

Paraproteinemias

Blood Protein Disorders

Hematologic Diseases

Hemorrhagic Disorders

Lymphoproliferative Disorders

Immunoproliferative Disorders

Precancerous Conditions

Hypergammaglobulinemia

Patients with high-risk smoldering myeloma will be prospectively followed and chart review will be performed to determine if progression events happen, and how they happen.

All patients will undergo the following standard of care interventions:

* Imaging every 6 months with diffusion weighted whole body magnetic resonance imaging
* Bone marrow biopsy every year
* Labs every month for first year, and every two months for second year.

Patients with smoldering myeloma undergoing active surveillance with diffusion weighted whole body MRI.

Sharmilee Nuli

Bailee Daniels

Ghulam Rehman Mohyuddin, MD

The purpose of this study is to define the natural history of high-risk smoldering myeloma in a modern cohort of patients undergoing close standard of care follow-up with diffusion weighted whole body magnetic resonance imaging.

Smoldering Myeloma High-Risk Patient Observation and Longitudinal Insight Trial

Frequency and nature of progression events in a prospective cohort of patients with smoldering myeloma undergoing active surveillance with diffusion weighted whole body MRI

Determine longitudinal Quality of Life as assessed by the PROMIS-29 instrument. The PROMIS-29 scales will be scored using a T-score metric method. A score of 50 points represents the population average for each scale, and 10 points represent one standard deviation. Higher scores means a higher level of physical function.

Determine longitudinal Quality of Life as assessed by the PROMIS-29 instrument. The PROMIS-29 scales will be scored using a T-score metric method. A score of 50 points represents the population average for each scale, and 10 points represent one standard deviation. Higher scores means a higher level of pain interference.

Determine longitudinal Quality of Life as assessed by the PROMIS-29 instrument. The PROMIS-29 scales will be scored using a T-score metric method. A score of 50 points represents the population average for each scale, and 10 points represent one standard deviation. Higher scores means a higher level of anxiety.

University of Utah

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Smoldering Myeloma High-Risk Patient Observation and Longitudinal Insight Trial	NCT06212323	Smoldering Mult...	Patients with s...	18 Years -	University of Utah
Smoldering Myeloma High-Risk Patient Observation and Longitudinal Insight Trial	NCT06212323	Smoldering Mult...	Patients with s...	18 Years -	University of Utah

Spots Global Cancer Trial Database for patients with smoldering myeloma undergoing active surveillance with diffusion weighted whole body mri.