Neoplasms

All Conditions

Nervous System Diseases

Head and Neck Neoplasms

Thoracic Neoplasms

Nervous System Neoplasms

Pelvic Neoplasms

Antineoplastic Agents

All Drugs and Chemicals

Sunitinib

Angiogenesis Inhibitors

Growth Inhibitors

Protein Kinase Inhibitors

Enzyme Inhibitors

The use of the FDA approved drug sunitinib, used in an "off-label" manner with external beam radiation therapy.

Radiotherapy will be administered Monday through Friday for a maximum of 8 weeks. Total dose will depend on the patient's disease site.

External Beam Radiation Therapy

Adam P Dicker, MD, PhD

This study is using the combination of radiation and antiangiogenic agents (agents that destroy existing blood vessels) seems to be an approach to tumor cure.

The combination of ionizing radiation and antiangiogenic agents seems to be a counterintuitive approach to tumor cure because oxygen is a potent radiosensitizer and a reduction in oxygen concentration would be expected following a reduction in tumor vasculature after antiangiogenic treatment.

Phase IB Study Using Sunitinib Plus Radiation Therapy for Cancer Patients

A Phase IB, Open-Label, Safety Study of the Combination of Sunitinib and Radiation for the Treatment of Patients With Cancer

The purpose of this study is to determine the safety of the combination of the antiangiogenic, sunitinib, when combined with external beam radiotherapy.

Urine VEGF may be a biomarker of response. This translational approach may be useful to determine who benefits from treatment.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Phase IB Study Using Sunitinib Plus Radiation Therapy for Cancer Patients	NCT00437372	Cancer Head and Neck C... Pelvic Cancer Nervous System ... Thoracic Neopla...	Sunitinib External Beam R...	18 Years -	Thomas Jefferson University
Phase IB Study Using Sunitinib Plus Radiation Therapy for Cancer Patients	NCT00437372	Cancer Head and Neck C... Pelvic Cancer Nervous System ... Thoracic Neopla...	Sunitinib External Beam R...	18 Years -	Thomas Jefferson University
Phase IB Study Using Sunitinib Plus Radiation Therapy for Cancer Patients	NCT00437372	Cancer Head and Neck C... Pelvic Cancer Nervous System ... Thoracic Neopla...	Sunitinib External Beam R...	18 Years -	Thomas Jefferson University

Spots Global Cancer Trial Database for pelvic area

Every month we try and update this database with for pelvic area cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for pelvic area

Every month we try and update this database with for pelvic area cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for pelvic area cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.