Spots Global Cancer Trial Database for head and neck cancer
Every month we try and update this database with for head and neck cancer cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Paclitaxel and Bortezomib in Treating Patients With Metastatic or Unresectable Malignant Solid Tumors | NCT00667641 | Breast Cancer Colorectal Canc... Head and Neck C... Lung Cancer Melanoma (Skin) Ovarian Cancer Pancreatic Canc... Prostate Cancer Unspecified Adu... | bortezomib paclitaxel | 18 Years - | Rutgers, The State University of New Jersey | |
| Capecitabine For Nasopharyngeal Cancer | NCT00095901 | Head and Neck C... | Capecitabine | 18 Years - | Dana-Farber Cancer Institute | |
| A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer | NCT00409565 | Head and Neck C... Squamous Cell C... | Cetuximab Bevacizumab | 18 Years - 98 Years | National Cancer Institute (NCI) | |
| Outcomes of Prophylactic Swallowing Therapy in Patients Undergoing Definitive Chemoradiation for Head and Neck Cancer | NCT03435471 | Head and Neck C... Oropharynx Canc... | Prophylactic Sw... Clinician-Direc... | 18 Years - | University of Miami | |
| A Study of SBRT for Squamous Cell Carcinoma of the Head and Neck | NCT04435938 | Head and Neck N... Squamous Cell C... Squamous Skin C... | Stereotactic Bo... | 60 Years - | McMaster University | |
| Irinotecan and Cisplatin in Treating Patients With Recurrent or Metastatic Head and Neck Cancer | NCT00639769 | Head and Neck C... | cisplatin irinotecan hydr... | 18 Years - | Vanderbilt-Ingram Cancer Center | |
| Cisplatin With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic or Recurrent Head and Neck Cancer | NCT00003809 | Head and Neck C... | cetuximab cisplatin | 18 Years - 120 Years | Eastern Cooperative Oncology Group | |
| Induction Chemotherapy Followed by Chemoradiation With Cetuximab in Head and Neck Cancer | NCT00868491 | Head and Neck C... | docetaxel, cisp... radiotherapy cetuximab, cisp... | 18 Years - | Institute of Oncology Ljubljana | |
| MAGE-A10ᶜ⁷⁹⁶T for Urothelial Cancer, Melanoma or Head and Neck Cancers | NCT02989064 | Urothelial Carc... Head and Neck C... Melanoma Bladder Urothel... | Autologous gene... | 18 Years - 75 Years | Adaptimmune | |
| Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist) | NCT04198766 | Solid Tumor Non-Small Cell ... Melanoma Head and Neck C... Gastric Cancer Renal Cell Carc... Urothelial Carc... | INBRX-106 - Hex... Pembrolizumab 2... Pembrolizumab 4... | 18 Years - | Inhibrx, Inc. | |
| Biomarkers in Patients With Head and Neck Cancer | NCT01466257 | Head and Neck C... | cetuximab cisplatin DNA analysis gene expression... mutation analys... laboratory biom... | 18 Years - 120 Years | Eastern Cooperative Oncology Group | |
| Nurse-led Exercise Improves Shoulder Pain, Shoulder Disability, and Quality of Life in Head and Neck Cancer | NCT05269342 | Head and Neck C... Cancer of Head ... Head and Neck N... | nurse-led couns... | 20 Years - | Hualien Tzu Chi General Hospital | |
| The Role of FDG PET in Radiation Treatment Planning for Head and Neck Cancers | NCT00230269 | Head and Neck C... | PET-CT | 18 Years - | Stanford University | |
| Blinded Dry Mouth Spray Crossover Study | NCT04608773 | Xerostomia Head and Neck C... Xerostomia Foll... | Remineralizing ... Alcohol-Free Mo... | 18 Years - | University of Pittsburgh | |
| Regional Anaesthesia and Substance P in Head and Neck Cancer | NCT03081897 | Head and Neck C... | SPRANC Block gr... SPRANC Control ... | 18 Years - | Charite University, Berlin, Germany | |
| A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1 | NCT04534205 | Unresectable He... Metastatic Head... Recurrent Head ... | BNT113 Pembrolizumab | 18 Years - | BioNTech SE | |
| A Randomized Comparative Study of a Weekly Versus Every Other Week Nurse Practitioner-led Symptom Management Clinic for Head and Neck Cancer Patients Undergoing Concurrent Chemotherapy and Radiation | NCT02085525 | Head and Neck C... | Nurse Practitio... | 18 Years - | University of Michigan Rogel Cancer Center | |
| TRACE: Tirapazamine-Radiation And Cisplatin Evaluation | NCT00174837 | Head and Neck S... | Tirapazamine Cisplatin | 18 Years - | Sanofi | |
| Multimodal Monitoring of Radiotherapy Response in Squamous Cell Cancer | NCT02379039 | Squamous Carcin... Head and Neck C... Anal Cancer Lung Cancer Esophageal Canc... Cervix Cancer | 18 Years - | Umeå University | ||
| COX-2 Inhibitor With Concurrent Chemoradiation in Locally Advanced Head & Neck Carcinoma | NCT00603759 | Head and Neck C... | celecoxib placebo | 20 Years - | Tehran University of Medical Sciences | |
| Sexual Behavior in Head and Neck Cancer Patients | NCT00662662 | Oropharyngeal C... Head and Neck C... Squamous Cell C... | Questionnaire | 18 Years - | M.D. Anderson Cancer Center | |
| Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03) | NCT04675294 | Head and Neck C... Head and Neck S... | evorpacept pembrolizumab | 18 Years - | ALX Oncology Inc. | |
| Liposomal Lurtotecan Plus Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors | NCT00006036 | Head and Neck C... Lung Cancer Ovarian Cancer Unspecified Adu... | cisplatin lurtotecan lipo... | 18 Years - 120 Years | Canadian Cancer Trials Group | |
| Study of Pembrolizumab in the First Line Therapy for R/M HNSCC in China | NCT04740996 | Head and Neck S... | Pembrolizumab | 18 Years - | ChineseAMS | |
| Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer | NCT00496236 | Head and Neck C... Head and Neck N... | TNFerade biolog... | 18 Years - | GenVec | |
| S9709, Laser Surgery Plus Radiation Therapy in Treating Patients With Early Stage Cancer of the Larynx | NCT00003040 | Head and Neck C... | laser surgery radiation thera... | 18 Years - | SWOG Cancer Research Network | |
| 3D Specimen Maps for RT Planning | NCT05743569 | Head and Neck C... Head and Neck S... Radiation Thera... | 28 Years - | Vanderbilt University Medical Center | ||
| MucoLox Formulation to Mitigate Mucositis Symptoms in Head/Neck Cancer | NCT03461354 | Mucositis Oral Head and Neck C... | MucoLox Sodium Bicarbon... | 18 Years - | Wake Forest University Health Sciences | |
| T-Lymphocytes in Treating Patients With Epstein-Barr Virus-Positive Nasopharyngeal Cancer, NPC | NCT00609219 | Head and Neck C... | autologous EBV ... | - | Baylor College of Medicine | |
| Genetically-informed Therapies for Patients With Metastatic Cancer | NCT02000739 | Metastatic Canc... | Genetically Inf... | 18 Years - | Dartmouth-Hitchcock Medical Center | |
| Zalutumumab in Combination With Radiotherapy in Head and Neck Cancer Patients Ineligible for Platinum Based Chemotherapy | NCT00707655 | Head and Neck C... Squamous Cell C... | Zalutumumab | 18 Years - | Genmab | |
| Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer | NCT00496236 | Head and Neck C... Head and Neck N... | TNFerade biolog... | 18 Years - | GenVec | |
| Psychological and Psychiatric prOfile in Glioblastoma and Head and Neck Cancer | NCT06385132 | Glioblastoma Head and Neck C... | Psychological T... | 18 Years - 75 Years | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | |
| Effect of Exercise in Head and Neck Cancer Patients | NCT05256238 | Head and Neck C... | comprehensive s... | 18 Years - | Universitaire Ziekenhuizen KU Leuven | |
| PDE5 Inhibition Via Tadalafil to Enhance Anti-Tumor Mucin 1 (MUC1) Vaccine Efficacy in Patients With HNSCC | NCT02544880 | Head and Neck S... Head and Neck C... | Tadalafil Anti-MUC1 Vacci... Anti-Influenza ... Tadalafil Place... Anti-MUC1 Vacci... Standard of Car... Anti-Influenza ... | 18 Years - | University of Miami | |
| Serum Squamous Cell Carcinoma Antigen Level and Tumor Volume in Head and Neck Cancer | NCT02879968 | Head and Neck C... | Non-interventio... | 18 Years - | Prince of Songkla University | |
| Non-randomized, Open-label Study of Intralesional Nivolumab for High Risk Oral Premalignant Lesions | NCT05327270 | Head and Neck C... | Nivolumab | 18 Years - | M.D. Anderson Cancer Center | |
| Lenalidomide and Cetuximab in Patients With Advanced Solid Tumors | NCT01166035 | Solid Tumors | Lenalidomide Cetuximab | 18 Years - 80 Years | Medical University Innsbruck | |
| Clinical Investigation on the Treatment of Radiation Induced Dermatitis With Radiation Care® Gel | NCT04995328 | Radiation Derma... | Radiation Care ... | 20 Years - | China Medical University Hospital | |
| Motivational Counseling in Preventing Smoking Relapse After Pregnancy in Pregnant Women Who Quit Smoking During Pregnancy | NCT00310115 | Bladder Cancer Cervical Cancer Esophageal Canc... Gastric Cancer Head and Neck C... Kidney Cancer Leukemia Liver Cancer Lung Cancer Pancreatic Canc... Tobacco Use Dis... | Smoking Prevent... Counseling Inte... Counseling Inte... | 18 Years - | M.D. Anderson Cancer Center | |
| Immunonutrition Supplementation in Head and Neck Cancer Patients Undergoing Cancer Treatment Study | NCT05526040 | Head and Neck C... | Immunonutrient-... Standard medica... | 18 Years - | University of Malaya | |
| Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma | NCT02325401 | Head and Neck C... | Metformin Cisplatin Radiation Thera... | 18 Years - | University of Cincinnati | |
| Genetically-informed Therapies for Patients With Metastatic Cancer | NCT02000739 | Metastatic Canc... | Genetically Inf... | 18 Years - | Dartmouth-Hitchcock Medical Center | |
| Towards A Better Paradigm for Head and Neck Cancer Treatment Applying Artificial Intelligence. HNC-TACTIC. | NCT05117775 | Head and Neck C... | No intervention... | 18 Years - | Savana Research | |
| Sentinel Node in Larynx and Pharynx Cancers | NCT04068636 | Head and Neck C... Lymph Node Meta... | Radioactive tra... | 18 Years - | Radboud University Medical Center | |
| Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy | NCT03719690 | HRAS Gene Mutat... HNSCC | Tipifarnib HRAS Detection ... | 18 Years - | Kura Oncology, Inc. | |
| A Phase I Trial of Abraxane, Cisplatin and 5-Fluorouracil Along With Chemoradiotherapy in Advanced Head and Neck Cancer | NCT00731380 | Head and Neck C... | ABI-007 | 18 Years - | University Health Network, Toronto | |
| Amifostine With IMRT for Submandibular and Sublingual Salivary Sparing During Head and Neck Cancer Treatment | NCT00409331 | Head and Neck C... | Amifostine Intensity- Modu... | 18 Years - | M.D. Anderson Cancer Center | |
| Low Antioxidant Diet in Controlling Cachexia in Patients With Oropharyngeal Cancer Receiving Chemotherapy and Radiation Therapy | NCT00486304 | Cachexia Head and Neck C... Weight Changes | ADD Placebo | 18 Years - | UNC Lineberger Comprehensive Cancer Center | |
| The Use of Photobiomodulation in the Management of Radiodermatitis in Head and Neck Cancer Patients | NCT05557825 | Radiodermatitis... Radiotherapy Si... Head and Neck C... | Photobiomodulat... | - | University of Nove de Julho | |
| Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers | NCT00568490 | Head and Neck C... Lung Cancer Lip Cancer Lip Neoplasms Head and Neck C... | Tumor biopsy Phlebotomy | 18 Years - | Stanford University | |
| Hearing Loss and the Effects of Statin Drugs in People With Head and Neck Squamous Cell Carcinoma Treated With Cisplatin Chemoradiation | NCT03225157 | Head and Neck N... Hearing Disorde... Hyperlipidemia | 18 Years - | National Institutes of Health Clinical Center (CC) | ||
| Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC | NCT05516589 | Head and Neck S... | Nab-paclitaxel Cisplatin Tislelizumab Afatinib | 18 Years - | West China Hospital | |
| RAD001 in Combination With Cetuximab and Cisplatin in Recurrent and Metastatic SCCHN | NCT01009346 | Head and Neck C... | RAD001 Cetuximab Cisplatin Carboplatin | 18 Years - | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| Evaluation of Intraoperative Usage of Sentinella in Detecting Sentinel Lymph Nodes | NCT02416336 | Melanoma Head and Neck C... Breast Cancer | Sentinella Intr... | - | Oncovision Inc | |
| Docetaxel in Treating Patients With Solid Tumors and Abnormal Liver Function | NCT00002901 | Breast Cancer Head and Neck C... Lung Cancer Ovarian Cancer Unspecified Adu... | docetaxel | 18 Years - | City of Hope Medical Center | |
| ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy | NCT05318027 | Lung Cancer Gastrointestina... Head and Neck C... | ChatBot | 18 Years - | Abramson Cancer Center at Penn Medicine | |
| Oral HPV Infection in Young Men | NCT00897273 | Head and Neck C... Infection Precancerous Co... | comparative gen... gene expression... study of socioe... evaluation of c... study of high r... | 18 Years - 21 Years | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| Validity and Reliability of the Turkish Version of the Neck Dissection Impairment Index | NCT04265313 | Quality of Life Head and Neck C... | Measurement of ... | 18 Years - 80 Years | Izmir Bakircay University | |
| STAT3 DECOY in Head and Neck Cancer | NCT00696176 | Head and Neck C... | STAT 3 DECOY | 18 Years - | University of Pittsburgh | |
| Head and Neck Cancer Registry (LORHAN) | NCT01080313 | Head and Neck C... | Therapy for hea... | 18 Years - | Eli Lilly and Company | |
| A Dose Finding Study of Eribulin Mesylate and Cetuximab For Patients With Advanced Head and Neck and Colon Cancer | NCT01744340 | Head and Neck C... Colon Cancer | Head and neck Colon- Closed a... | 18 Years - | Brown University | |
| NIR Fluorescence Imaging During Neck Dissection in Head and Neck Cancer Patients After iv Injection of ICG | NCT02027831 | Head and Neck C... | Indocyanine Gre... | 18 Years - | Jules Bordet Institute | |
| Pain Management Smartphone Application for Patients With Stage III-IV Head and Neck Cancer Undergoing Radiation Therapy | NCT02324881 | Head and Neck C... Pain Lung Cancer Esophageal Canc... | Telephone-Based... Questionnaire A... | 18 Years - | Vanderbilt-Ingram Cancer Center | |
| Submandibular Gland Stem Cell Transplantation | NCT04593589 | Head and Neck C... | Submandibular G... | 18 Years - | University Medical Center Groningen | |
| Short Course Radiation Therapy in Palliative Treatment | NCT03196700 | Palliative Care | Short course ra... | 18 Years - | IRCCS Azienda Ospedaliero-Universitaria di Bologna | |
| Irinotecan and Docetaxel in Treating Patients With Metastatic or Locally Recurrent Head and Neck Cancer | NCT00040807 | Head and Neck C... | docetaxel irinotecan hydr... | 18 Years - 120 Years | Eastern Cooperative Oncology Group | |
| Phase 1/1b Study of MGCD516 in Patients With Advanced Cancer | NCT02219711 | Advanced Cancer | MGCD516 | 18 Years - | Mirati Therapeutics Inc. | |
| NGR-TNF in Treating Patients With Advanced Solid Tumors | NCT00098943 | Colorectal Canc... Head and Neck C... Kidney Cancer Unspecified Adu... | CNGRC peptide-T... | 18 Years - | European Organisation for Research and Treatment of Cancer - EORTC | |
| A Pharmacokinetic Study of Nutri-PEITC Jelly in Head and Neck Cancer Survivors | NCT03700983 | Head and Neck C... | Nutri-PEITC jel... | 20 Years - | Dental Innovation Foundation Under Royal Patronage | |
| A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours | NCT04969835 | Pancreatic Canc... Colorectal Canc... Non-small Cell ... Head and Neck C... Cancer of Unkno... Ovarian Cancer Breast Cancer Soft Tissue Sar... Bladder Cancer Oesophageal Can... Prostate Cancer Biliary Tract C... | AVA6000 | 18 Years - | Avacta Life Sciences Ltd | |
| Phase 1 Study of BAY1905254 - An Early Clinical Research Study to Evaluate a New Drug Called Bapotulimab (BAY1905254) in the Expansion Cohort in Combination With Pembrolizumab in Head and Neck Cancer That Has Returned or is Discovered to be Metastatic and is Expressing PDL1. | NCT03666273 | Advanced Solid ... Head and Neck S... | Bapotulimab (BA... Bapotulimab (BA... | 18 Years - | Bayer | |
| CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors | NCT04660929 | HER2-positive Adenocarcinoma Bile Duct Cance... Biliary Tract C... Bladder Cancer Breast Cancer Breast Neoplasm Carcinoma, Duct... Carcinoma, Hepa... Cancer Lung Cancer, No... Carcinoma, Ovar... Carcinoma, Smal... Carcinoma, Squa... Carcinoma, Tran... Colorectal Canc... Esophagogastric... Inflammatory Br... Stomach Neoplas... Malignant Neopl... Ovarian Neoplas... Pancreatic Canc... HER2-positive S... HER2-positive B... HER2-positive G... HER-2 Protein O... HER-2 Gene Ampl... Prostate Cancer Head and Neck C... Endometrial Can... Lung Cancer, Sm... | CT-0508 Pembrolizumab | 18 Years - | Carisma Therapeutics Inc | |
| Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma | NCT03336606 | Head and Neck C... Head and Neck S... Melanoma Cell Cancer, Sq... Carcinoma, Squa... | MEDI0562 | 18 Years - | Providence Health & Services | |
| Cetuximab in Head and Neck Cancer Patients | NCT03769311 | Head and Neck C... Squamous Cell C... | Cetuximab | 18 Years - | University of Wisconsin, Madison | |
| Role of Pharyngeal High Resolution Manometry and Impedance in Swallow Function of Head and Neck Cancer Patients | NCT03372148 | Head and Neck C... Dysphagia | pHRMi | 18 Years - 100 Years | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| Radiotherapy of Tongue Cancer Using an Intraoral Stent | NCT04337853 | Tongue Cancer | Intraoral stent No intraoral st... | 18 Years - | Oslo University Hospital | |
| Palliative Expeditiously Adaptive Quad Shot Radiation Therapy (PEAQ-RT) | NCT04379505 | Head and Neck C... | Ring gantry kV-... Quad shot radia... | 18 Years - | Washington University School of Medicine | |
| Radiation Therapy With or Without Epoetin Alfa in Treating Anemic Patients With Head and Neck Cancer | NCT00004917 | Anemia Head and Neck C... | epoetin alfa cisplatin radiation thera... | 18 Years - | Radiation Therapy Oncology Group | |
| A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours | NCT04969835 | Pancreatic Canc... Colorectal Canc... Non-small Cell ... Head and Neck C... Cancer of Unkno... Ovarian Cancer Breast Cancer Soft Tissue Sar... Bladder Cancer Oesophageal Can... Prostate Cancer Biliary Tract C... | AVA6000 | 18 Years - | Avacta Life Sciences Ltd |
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