Gland and Hormone Related Diseases

All Conditions

Neoplasms

Thyroid Diseases

Hyperthyroidism

Thyroid Nodule

Endocrine System Diseases

Thyroid Neoplasms

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Percutaneous Radiofrequency Thermal Ablation (RTA).

Percutaneous Radiofrequency Thermal Ablation (RTA) by using a RITA© StarBurst Talon needle (RITA Medical Systems, Fremont, CA). RTA is performed in each patient at Time 0.

Percutaneous Radiofrequency Thermal Ablation

Annamaria Colao

Percutaneous radiofrequency thermal ablation (RTA) was reported as an effective tool for the management of thyroid nodules (TNs). This study aims to validate RTA as a valid approach for patients with compressive TNs for whom surgery is contraindicated or refused. Two groups of subjects with TNs (one group to treat with RTA and a matched untreated control group) will be evaluated in term of TN volume, thyroid hormones and clinical symptoms.

Thyroid nodules (TNs) are very common in the general population, with a prevalence of about 50% in subjects older than 60 years undergoing neck ultrasound examination.

The great majority of TNs are benign, but they can be responsible for pressure symptoms in the neck and result in discomfort and decreased quality of life. Large compressive TNs may result in life-threatening conditions because of the potential acute onset of respiratory crisis. Percutaneous radiofrequency thermal ablation (RTA) is a minimally invasive procedure which has been firstly develop to treat patients with liver cancer and has been then used to treat both malignant and benign tumor nodules in many organs. RTA also represents a promising new approach for the management of TNs.The current prospective comparative study investigated the long-term effectiveness of RTA in patients with both toxic and non-toxic compressive TNs.

Forty consecutive patients with TNs with pressure symptoms were prospectively enrolled in this study. Patients were randomised as follows: 20 patients were treated with a single RTA session (group A) and 20 patients did not receive any treatment and were only followed-up (group B).

Percutaneous Radiofrequency Thermal Ablation in Compressive Thyroid Nodules

Thyroid Nodules Treated With Percutaneous Radiofrequency Thermal Ablation: a Comparative Study

Evaluation of TN volume by using Ultrasonography.

Evaluation of TN-related neck symptoms scored separately as follows: 0 (absent), 1 (moderate), and 2 (severe). The sum of the individual scores generates a final score (SYS score) ranging from 0 to 6.

Evaluation of TN hyperfunction by measuring serum concentrations of TSH, free thyroxine (fT4), free triiodothyronine (fT3) in patients with toxic TNs.

Assessment of local impairment (pain, oedema, skin damage). Assessment of thyroid dysfunction by measuring serum concentrations of fT3, fT4, TSH.

Assessment of thyroid autoimmunity (anti-Thyroglobulin and anti-Thyroperoxidase antibodies).

Evaluation of TN volume by using Ultrasonography

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Percutaneous Radiofrequency Thermal Ablation in Compressive Thyroid Nodules	NCT01649206	Thyroid Nodule	Percutaneous Ra...	18 Years - 87 Years	Federico II University
Percutaneous Radiofrequency Thermal Ablation in Compressive Thyroid Nodules	NCT01649206	Thyroid Nodule	Percutaneous Ra...	18 Years - 87 Years	Federico II University

Spots Global Cancer Trial Database for percutaneous radiofrequency thermal ablation