Neoplasms

All Conditions

Carcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

The patients submitted to periampullary cancer surgery will receive sugar pills in the preoperative and postoperative period.

The probiotics pills are given orally in the amount of two pills twice a day as early as two days before surgery until ten days after surgery.

Probiotics

Sugar pill

The purpose of this study is to evaluate the effect of the probiotic use in patients with periampullary cancers undergone curative or palliative treatment considering nutritional status, postoperative complications, infection rate, length of hospitalization and mortality.

Effect of Probiotics in Patients Undergoing Surgery for Periampullary Neoplasms

Effect of the Probiotics Use in Patients Undergoing Surgery for Periampullary Neoplasia - A Randomized Clinical Trial

Death will be considered as the primary outcome related to complications of surgical treatment in postoperative period

To assess postoperative infection rate in patients submitted to periampullary cancer surgery using probiotics.

FIPE - Fundo de Incentivo a Pesquisa do Hospital de Clínicas de Porto Alegre

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.

Hospital de Clinicas de Porto Alegre

nutritionist

Gastrointestinal Agents

All Drugs and Chemicals

Pancrelipase

Pancreatin

Pancreas-sparing duodenectomy for periampullary carcinoma is defined as resection of the descending segment of duodenum; resection of papilla of Vater; reimplantation of bile and pancreatic ducts and reconstruction of duodenum.The Japan Pancreatic Society (JPS) system for numbering of lymph node stations was adopted for accurate description of the surgery and pathological assessment.The standard lymph node groups removed as part of PSD were the anterior pancreatoduodenal groups (JPS LN17), the posterior pancreatoduodenal groups (JPS LN13), the dextroinferior nodes of the hepatoduodenal ligament node groups (JPS LN12), the infrapyloric node (JPS LN6), the nodes around the anterior aspect of the common hepatic artery (JPS LN8) and the nodes on the right side of the SMA (JPS LN14).

Pancreas-sparing duodenectomy

The surgical technique used for standard PD has been described before. Standard PD included clearance of all soft tissues and lymphatics immediately to the left of the superior mesenteric artery, as well as removal of the lymphoareolar tissue along the proximal hepatic artery.

Pancreaticoduodenectomy

Geng Chen, M.D.,Ph.D.

Ping Bie, M.D.,Ph.D.

The purpose of this study is to investigate the feasibility, safety, and long-term prognosis of pancreas-sparing duodenectomy with regional lymphadenectomy in the treatment of early-stage (pTis/pT1/pT2) periampullary carcinoma with or without lymph node metastasis

Pancreaticoduodenectomy (PD) is commonly used for periampullary carcinoma (PC). In recent years, morbidity and mortality rates following PD have decreased, but the operative stress induced by pancreatectomy is considerable. Less-invasive surgery should thus be elected for PC without pancreatic and diffuse lymph node involvement. From the perspective of organ-preserving resection, pancreas-sparing duodenectomy (PSD) represents an attractive option for selected periampullary tumors, and offers an alternative to PD.

Previous reports have described PSD for benign, premalignant and some selected malignant conditions of duodenum, and have emphasized this procedure as a safe and effective treatment associated with good quality of life. However, use of PSD for PC is still controversial.Available data about PSD for PC and published data from the follow-up evaluation in the literature are still limited.

Given the fact that 20%-60% pT1/pT2 patients have regional lymph node metastasis, regional lymph node dissection should be essential for PC. However, lymphadenectomy has never been promoted as a regular procedure of PSD.The aim of the present study was to investigate the feasibility, safety, and long-term results of PSD with regional lymphadenectomy for early-stage (pTis/pT1/pT2) periampullary cancers.

Pancreas-sparing Duodenectomy Versus Pancreatoduodenectomy for Early-stage Periampullary Carcinoma

Comparison of Pancreas-sparing Duodenectomy With Pancreatoduodenectomy for Early-stage Periampullary Carcinoma:A Prospective Non-Randomized Trial

Early postoperative complications consist of gastrointestinal/abdominal bleeding, pancreatic leakage, encephalopathy, delayed gastric emptying, diabetes mellitus and wound infection

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Effect of Probiotics in Patients Undergoing Surgery for Periampullary Neoplasms	NCT01468779	Periampullary C...	Probiotics Sugar pill	18 Years -	Hospital de Clinicas de Porto Alegre
Pancreas-sparing Duodenectomy Versus Pancreatoduodenectomy for Early-stage Periampullary Carcinoma	NCT01291927	Periampullary C...	Pancreas-sparin... Pancreaticoduod...	18 Years - 80 Years	Southwest Hospital, China
Effect of Probiotics in Patients Undergoing Surgery for Periampullary Neoplasms	NCT01468779	Periampullary C...	Probiotics Sugar pill	18 Years -	Hospital de Clinicas de Porto Alegre

Spots Global Cancer Trial Database for periampullary carcinoma nos