Neoplasms

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Carcinoma

Carcinoma, Squamous Cell

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Squamous Cell

The aim of the study is to evaluate patient's outcome according to the post-radiation lymphocytes count and to the changes induced in the immune cell population by a loco-regional treatment as radiotherapy. The way to objectivate these results is to collect some blood samples and analyze them.

Eveluation: circulating T cells CD3+CD8+ and CD3+CD4+, absolute lymphocyte count (ALC) and neutrophil counts (ANC) and neutrophil/lymphocyte ratio (NLR), Treg lymphocytes, Naïve/Memory T lymphocytes CD4+ and CD8+,myeloid-derived suppressor cells, Plasmacytoid Dendritic Cells NK cells dimension and bright, NKT cells, Myeloid Dendritic cells, Monocytes subsets, B lymphocytes ,Analysis of plasma cytokines (TNFalpha, TGFbeta, IL-6, IL-10) by ELISA,FN signature: real-time PCR on mRNA from peripheral blood mononuclear cells (PBMCs)

Peripheral blood sampling in order to evaluate changes in the circulating immune population

Aldo Roccaro, MD

Paolo Bossi, MD

Treatment with adjuvant radiotherapy modulates immune system in many diseases as witnessed by dynamic changes of humoral and cellular immunity. Moreover, the persistent lymphopenia after radiation therapy is a negative prognostic factor. This study is aimed to explore the changes in immune-cell populations during radiotherapy given as adjuvant treatment for high-risk cutaneous squamous cell carcinomas and to correlate them with patient's outcome.

Immune System Modulation and Outcome in High-risk cSCC Treated With Surgery and Radiotherapy

Immune System Modulation and Outcome in High-risk Cutaneous Squamous Cell Carcinoma Treated With Surgery and Radiotherapy: a Prospective Study

Disease-free survival (DFS) of patients with ALC \< 500 cells/mL 28 days after the end of radiotherapy treatment

Evaluation of changes (Δ) in the circulating immune-cells population before the start of radiotherapy and 28 days after the end of radiotherapy.

Correlation between DFS and circulating immune cell population

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Immune System Modulation and Outcome in High-risk cSCC Treated With Surgery and Radiotherapy	NCT05246228	Squamous Cell C...	Peripheral bloo...	18 Years -	Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Immune System Modulation and Outcome in High-risk cSCC Treated With Surgery and Radiotherapy	NCT05246228	Squamous Cell C...	Peripheral bloo...	18 Years -	Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Spots Global Cancer Trial Database for peripheral blood sampling in order to evaluate changes in the circulating immune population