Nervous System Diseases

All Conditions

Peripheral Nervous System Diseases

Neuromuscular Diseases

Patients attend Tai Chi Easy class for 60 minutes once a week for 6 weeks. Patients also receive a DVD and exercise manual of Tai Chi Easy exercises and are encouraged to practice at home for 30 minutes most days per week for 6 weeks.

Patients receive readings each week and attend a book club to discuss the readings for 60 minutes once a week for 6 weeks.

Educational Intervention

Receive Tai Chi Easy class, DVD, and exercise manual

Exercise Intervention

Questionnaire Administration

Donald Northfelt

This pilot clinical trial studies how well Tai Chi Easy works in treating cancer survivors with peripheral sensory neuropathy. Tai Chi Easy is a simple and repetitive form of exercise that consists of movements with meditation and may improve peripheral neuropathy symptoms among cancer survivors.

PRIMARY OBJECTIVES:

I. Examine effects of Tai Chi Easy (TCEasy) exercise intervention on peripheral sensory neuropathy of cancer survivors who have chemotherapy compared with an educational control (EC) intervention.

OUTLINE: Patients are randomized to 1 of 2 groups.

GROUP I (TAI CHI EASY): Patients attend Tai Chi Easy class for 60 minutes once a week for 6 weeks. Patients also receive a DVD and exercise manual of Tai Chi Easy exercises and are encouraged to practice at home for 30 minutes most days per week for 6 weeks.

GROUP II (EDUCATIONAL CONTROL): Patients receive readings each week and attend a book club to discuss the readings for 60 minutes once a week for 6 weeks.

After completion of study, patients are followed up at 2 months.

Tai Chi Easy in Treating Cancer Survivors With Peripheral Sensory Neuropathy

Pilot Study of Effects of Tai Chi Easy on Cancer Survivors Experiencing Neuropathy

Will be assessed with a simple t-test of mTNS means. Additional analyses of factors assessed will similarly be conducted (and overall analysis of variance when combining outcome variable assessment at the three time points, and models of factor contribution with logistic regression if appropriate).

Will be measured directly using standardized protocols with medical-quality calibrated balance scales.

National Cancer Institute (NCI)

Mayo Clinic

Micronutrients

Nootropic Agents

All Drugs and Chemicals

Hematinics

Other Dietary Supplements

Vitamins

Acetylcarnitine

Folic Acid

Vitamin B Complex

Trace Elements

Carnitine

Folate

Vitamin B9

Administration of enteric-coated tablets with warm water at half an hour after meals, 1g (2 tablets) each time, 3 times a day, and the interval at or \>4 hours for 8 weeks

Placebo

Chemotherapy-induced peripheral neuropathy (CIPN) is a common clinical dose-limiting adverse drug reaction, and the primary manifestations are different degree of neuromotor, sensorineural and autonomic nervous dysfunction.

This multicenter, randomized, double-blind, placebo-controlled and parallel clinical trial is to observe the efficacy and safety of the Acetyl-L-Carnitine Hydrochloride enteric-coated tablets in treatment of peripheral sensory neuropathy that anti-cancer chemotherapeutics induce.

Clinical Study on Acetyl-L-Carnitine

Phase III Study of Acetyl-L-Carnitine (ALC) Hydrochloride Enteric-coated Tablets in Treatment of Peripheral Sensory Neuropathy in Anti-cancer Chemotherapeutics Induce

Changes in peripheral sensory neuropathy grades after eight weeks treatment

Changes in Neuroelectrophysiological test after eight weeks ALC or placebo treatment

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Tai Chi Easy in Treating Cancer Survivors With Peripheral Sensory Neuropathy	NCT01980368	Cancer Survivor Peripheral Sens...	Educational Int... Exercise Interv... Questionnaire A...	18 Years -	Mayo Clinic
Clinical Study on Acetyl-L-Carnitine	NCT01526564	Peripheral Sens...	Acetylcarnitine Placebo	18 Weeks - 75 Years	Lee's Pharmaceutical Limited

Spots Global Cancer Trial Database for peripheral sensory neuropathy