Neoplasms

All Conditions

Digestive System Diseases

Rare Diseases

Carcinoma

Carcinoma, Hepatocellular

Liver Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Adenocarcinoma

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Liver Diseases

Primary Liver Cancer

Hematinics

All Drugs and Chemicals

Liver Extracts

MRI of the liver as classic work out of patients (CT-scan if MRI is contra-indicated)

MRI of the liver before start of treatment

MRI of the liver after 3 - 6 months of treatment (CT-scan if MRI is contra-indicated)

MRI after treatment

PET-scan with 2 tracers is performed before treatment start

PET-scan before treatment start

PET-scan with 2 tracers is repeated 4 weeks following start of treatment

PET scan after treatment

Bieke Lambert, MD

Present imaging modalities for primary liver cancer (hepatocellular carcinoma or HCC) have several shortcomings. One important shortcoming is the time delay between successful treatment and radiological confirmation of this response. Often it takes several months for anatomical changes to occur and to be appreciated on morphological imaging such as CT or MRI (shrinkage of tumor, absence of contrast enhancement). Functional imaging by means of Fluor-18 deoxyglucose or Fluor-18 Choline (positron emitters, PET-scan) might be an early indicator of response. This "early" information might help to tailor treatment. For instance, if no response is induced, an early switch in therapy can be planned.

The present study investigates whether the routine PET-tracer (Fluor-18 deoxyglucose) and the experimental PET-tracer, Fluor-18 Choline help to predict response if a patient with inoperable primary liver cancer is treated (radionuclide therapy, biologicals).

Role PET Imaging in Response Assessment for Hepatocellular Carcinoma (HCC)

University Ghent

University Hospital, Ghent

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Role PET Imaging in Response Assessment for Hepatocellular Carcinoma (HCC)	NCT01116804	Primary Liver C...	MRI of the live... MRI after treat... PET-scan before... PET scan after ...	18 Years -	University Hospital, Ghent
Role PET Imaging in Response Assessment for Hepatocellular Carcinoma (HCC)	NCT01116804	Primary Liver C...	MRI of the live... MRI after treat... PET-scan before... PET scan after ...	18 Years -	University Hospital, Ghent
Role PET Imaging in Response Assessment for Hepatocellular Carcinoma (HCC)	NCT01116804	Primary Liver C...	MRI of the live... MRI after treat... PET-scan before... PET scan after ...	18 Years -	University Hospital, Ghent
Role PET Imaging in Response Assessment for Hepatocellular Carcinoma (HCC)	NCT01116804	Primary Liver C...	MRI of the live... MRI after treat... PET-scan before... PET scan after ...	18 Years -	University Hospital, Ghent

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