Neoplasms

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Skin Diseases, Vascular

Systemic Scleroderma

Vasodilator Agents

Platelet Aggregation Inhibitors

All Drugs and Chemicals

Iloprost

Subjects will receive study drug for 5 consecutive days as an IV infusion over 6 hours each day via a peripheral line. Study drug will be initiated at a starting dose 0.5 ng/kg/min up to 2.0 ng/kg/min.

Study drug will be initiated at a starting dose of 0.5 ng/kg/min up to 2.0 ng/kg/min. Subjects will receive study drug for 5 consecutive days as an IV infusion over 6 hours each day via a peripheral line.

Placebo IV infusion

Iloprost Injection, for intravenous use

Wade Benton, Pharm D

This is a Phase 3, multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of iloprost on the frequency of and relief from symptomatic digital ischemic episodes in subjects with systemic sclerosis.

Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 3)

A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase 3 Study Evaluating the Safety and Efficacy of Intravenous Iloprost in Subjects With Systemic Sclerosis Experiencing Symptomatic Digital Ischemic Episodes (AURORA Study)

The primary efficacy parameter is the change in the weekly frequency of symptomatic RP attacks from baseline

Eicos Sciences, Inc.

This is a Phase 2, multicenter, double-blind, randomized, placebo-controlled study to evaluate the effect of iloprost on the symptomatic relief of Raynaud's Phenomenon attacks in subjects with symptomatic Raynaud's Phenomenon secondary to Systemic Sclerosis.

Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 2)

A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase 2 Pilot Study Evaluating Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis

The primary efficacy parameter is the change in the weekly frequency of symptomatic RP attacks from baseline.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 3)	NCT04040322	Raynaud's Pheno...	Placebo IV infu... Iloprost Inject...	18 Years -	Eicos Sciences, Inc.
Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 2)	NCT03867097	Raynaud Phenome...	Placebo IV infu... Iloprost Inject...	18 Years -	Eicos Sciences, Inc.
Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 3)	NCT04040322	Raynaud's Pheno...	Placebo IV infu... Iloprost Inject...	18 Years -	Eicos Sciences, Inc.
Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 3)	NCT04040322	Raynaud's Pheno...	Placebo IV infu... Iloprost Inject...	18 Years -	Eicos Sciences, Inc.

Spots Global Cancer Trial Database for placebo iv infusion