Nutritional and Metabolic Diseases

Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Overweight

Syndrome

Polycystic Ovary Syndrome

Overnutrition

Nutrition Disorders

Body Weight

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Bone Density Conservation Agents

Micronutrients

All Drugs and Chemicals

Anticoagulants

Reproductive Control Agents

Other Dietary Supplements

Vitamins

Mineral

Vitamin D

Cholecalciferol

Calcium

Citric Acid

Sodium Citrate

Calcium, Dietary

Clomiphene

Enclomiphene

Zuclomiphene

Trace Elements

Hormones

Chelating Agents

Estrogens

Estrogen Antagonists

Estrogen Receptor Antagonists

Hormone Antagonists

Estrogen Receptor Modulators

Selective Estrogen Receptor Modulators

Citrate

Vitamin D3

Calciferol

Calcium Supplement

93 women who will receive clomiphene citrate for induction of ovulation with vitamin D and calcium supplement

93 women who will receive clomiphene citrate for induction of ovulation with placebo and calcium supplement

1. Vitamin D ( ossofortin®, EVA PHARMA) 10000 IU twice weekly and calcium (calciprex®, Marcyrl Pharmaceutical Industries ) 1250 mg twice daily which provide elemental calcium 500 mg/tablet for one month before induction of ovulation and both will be continued during the 3 induction cycles in the same regimen.
2. Induction of ovulation by clomiphene citrate (Clomid®, Aventis) 50 mg tablet twice daily 12 hours apart (total dose 100 mg daily) starting from the third day of menstrual cycle and for five days .

Vitamin D with calcium and clomiphene citrate

1. The placebo tablet twice weekly and calcium (calciprex®, Marcyrl Pharmaceutical Industries ) 1250 mg twice daily which provide elemental calcium 500 mg/tablet for one month before induction of ovulation and both will be continued during the 3 induction cycles in the same regimen.
2. induction of ovulation by clomiphene citrate (Clomid®, Aventis) 50 mg tablet twice daily 12 hours apart (total dose 100 mg daily)starting from the 3rd day of menstrual cycle and for five days

Placebo Oral Tablet with calcium and clomiphene citrate

Radwa R Ali

Radwa R Ali, MD

The aim of this work is to evaluate the effect of vitamin D supplementation in overweight infertile women with PCOs undergoing induction of ovulation.

The study will include overweight infertile women with PCOS seeking fertility who will receive induction of ovulation by clomiphene citrate will be recruited and randomized into two groups:

Group A (study group): 93 women who will receive clomiphene citrate for induction of ovulation with vitamin D and calcium supplement

Group B (control group): 93 women who will receive clomiphene citrate for induction of ovulation with placebo and calcium supplement

Effect of Vitamin D Supplement in Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome

Effect of Adding Vitamin D Supplement to Clomiphene Citrate for Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome

* Transvaginal ultrasound will be done to detect signs of ovulation: corpus luteum, fluid in cul-de-sac, collapse of the follicle size.
* Serum progesterone will be measured in the mid luteal day of the cycle, where:

Level 19 nmol/L indicates Ovulation. Level \<5 nmol/L suggests Ovulation did not occur

could be impaired with antiestrogenic effect of clomiphen citrate

hot flashes, headache, nausea, vomiting, breast tenderness, blurred vision, abdominal distention and pain and ovarian enlargement or hyperstimulation.

Ain Shams University

lecturer

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Effect of Vitamin D Supplement in Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome	NCT03396380	Ovulation Induc...	Vitamin D with ... Placebo Oral Ta...	25 Years - 35 Years	Ain Shams University
Effect of Vitamin D Supplement in Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome	NCT03396380	Ovulation Induc...	Vitamin D with ... Placebo Oral Ta...	25 Years - 35 Years	Ain Shams University

Spots Global Cancer Trial Database for placebo oral tablet with calcium and clomiphene citrate