Infections

Skin and Connective Tissue Diseases

All Conditions

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Warts

Communicable Diseases

Papillomavirus Infections

Virus Diseases

DNA Virus Infections

Skin Diseases

Skin Diseases, Viral

Tumor Virus Infections

Skin Diseases, Infectious

Hypoglycemic Agents

All Drugs and Chemicals

Pharmaceutical Solutions

Anticoagulants

Other Dietary Supplements

Insulin

Insulin, Globin Zinc

Citric Acid

Sodium Citrate

Citrate

patients will be injected with intralesional C.albicans antigen

patients will receive intralesional autologous PRP injection

patients will receive intralesional saline

a test dose (0.1 ml) of the C. albicans antigen will be injected intradermally into the skin of the forearm. A reaction will be considered positive in presence of ≥5 mm erythema and induration after 48-72 hr. Only reactors will be included. patients will receive intralesional injection of candida antigen at a dose 0.1 ml of 1/1000 solution into the largest wart at 3 weekly intervals for a total of 3 doses.

C. albicans antigen

patients will receive intralesional autologous PRP injection every month until a complete clearance or for a maximum of 2 sessions. 20 cc blood will be collected under a complete aseptic condition in citrate tubes . The lower 2-4 cc of the plasma will be provided as PRP concentrate after centrifugation. 0.1 ml of PRP will be injected intralesional with an insulin syringe.

autologous PRP

patients will receive intralesional saline at a dose of 0.3ml into the largest wart at 2-week intervals until complete clearance is achieved or for a maximum of five treatment

saline

Hassan M Ibrahim, Ass. Prof.

Mohamed A Ali, Prof. Dr.

Eisa M Hegazy, Ass. Prof.

To compare the efficacy of intralesional injection of autologous plasma rich platelets and candida antigen in treatment of patients with plane warts .

Cutaneous warts are benign tumors caused by infection of keratinocytes by different serotypes of human papillomavirus(HPV). Its incidence increases during the school years to reach a peak in adolescence and early adulthood, then declines rapidly through the twenties and more gradually thereafter.

Plane warts are mainly caused by HPV serotypes 3, 10, 28, and 41, presenting mainly in children and young adults. They present as skin colored or may be hyperpigmented smooth-surfaced, slightly elevated or flat-topped papules. They are polygonal or round in shape and range in sizes from 1 to 5 mm. The main sites of predilection for the plane warts are the face, dorsal aspects of the hands and forearms, often in a linear array.

Platelet rich plasma (PRP) is an autologous blood-derived product enriched in platelets. Platelets, also called thrombocytes, are blood cells that cause blood clots and other necessary growth healing functions. PRP represents a new bio technology that is part of the growing interest in tissue engineering and cellular therapy today. While it is of autologous origin, it reduces the possibility of adverse effects and transfusion-transmitted infections, so it is well-tolerated therapy for the patients. PRP has been used in the treatment of many cutaneous diseases such as alopecia and acne vulgaris. Its utility has been extended to other cutaneous diseases as melasma, hyperpigmentation, and burns, wherever it elicits tissue repair and regeneration.

Intralesional immunotherapy depends on the ability of the immune system to recognize certain viral, bacterial, and fungal antigens, such as Candida or Trichophyton antigens that induce a delayed-type hypersensitivity reaction, not only to the antigen but also against the wart virus, which in turn increases the ability of the immune system to recognize and eradicate HPV. This stimulated immune response could then subsequently destroy all the injected and noninjected lesions on the body, rather than the locally treated lesion.

Intralesional antigen immunotherapy has recently received increased attention and is considered by many authors a promising modality for the treatment of different types of warts, including the recurrent and recalcitrant variants.

Comparison Between Intralesional Injection of Plasma Rich Platelets and Candida Antigen in Plane Warts

Comparative Study Between Intralesional Injection of Autologous Plasma Rich Platelets Versus Candida Antigen in Patients With Plane Warts

Evaluation of the efficacy of intradermal injection of candida albicans antigen versus autologous platelet rich plasma in treatment of plane warts

Response to treatment will be evaluated by the decrease in size of warts. Lesions with size decrease of less than 50% will be defined as no therapeutic response, size decrease between 50 and 99% as relative response, and complete removal of the lesions will be considered as complete cure.

South Valley University

principal investigator

Dermatologic Agents

Anti-Infective Agents

Anti-Inflammatory Agents

Antirheumatic Agents

Analgesics

Sunscreening Agents

Salicylic Acid

Glycolic acid

Salicylates

Clotrimazole

Miconazole

Antifungal Agents

Keratolytic Agents

Anti-Inflammatory Agents, Non-Steroidal

Analgesics, Non-Narcotic

Cyclooxygenase Inhibitors

Enzyme Inhibitors

Prior to the procedure, patients will be instructed to avoid sun exposure during the treatment and to use broad spectrum sunscreen The treatment was started once daily over the entire face and maintained for two months. A fine layer of Glycolic Acid Plus Salicylic Acid face gel was applied on the whole surface where the warts were present, avoiding the eyelids and lips. In children 7 to 10 years of age, face gel was applied by their parents. Clinical controls were performed at Weeks 2, 4, 6, and 8.

Glycolic Acid Plus Salicylic Acid in Treatment of Plane Wart

To determine clinical efficacy of glycolic acid 15%plus salicylic acid 2% gel in treatment of Plane wart .

Warts are typically small, rough, hard growths that are similar in color to the rest of the skin. They typically asymptomatic , except when on the bottom of the feet, where they may be painful While they usually occur on the hands and feet, they can also affect other locations One or many warts may appear They are not cancerous .

Warts are caused by infection with human papillomavirus(HPV). Factors that increase the risk include use of public showers, working with meat, eczema and a weak immune system. The virus is believed to enter the body through skin that has been damaged slightly.

Warts are classified to common wart, plane wart, plantar wart, genital wart. Plane warts are circumscribed papules with hyperkeratotic surfaces that can occur singly or in groups. In these types of warts, the human papilloma virus (HPV) has been shown to infect the keratinocyte. Although no viral subtype is absolute, typically the infection is with HPV types 3, 10, 28, and 41 These warts are small in size (1-5mm), flat, or slightly elevated lesions. Plane viral warts typically present as skin-colored or light brownish,papules on the face, beard area, or on the back of the hands, and primarily affect children.

Plane warts can greatly affect a patient's quality of life, and their persistence or recurrence cause frustration.

Their evolution is variable, and although two thirds of cases regress spontaneously in the course of two years due to immunological mechanism

The following therapies have been used in the treatment of Plane wart with varying success: salicylic acid, cryotherapy, retinoic acid, photodynamic therapy (topical 5-aminolevulinic acid photodynamic therapy), pulsed dye laser (PDL), and Candida antigen.

New medication is a combination of glycolic acid 15% plus salicylic acid 2% gel.

Glycolic acid has been used in the treatment of Plane wart . It has been suggested that alpha-hydroxy acids can produce an authentic exfoliation and dehiscence of the coenocytes from recently formed layers of the stratum corneum. Alpha-hydroxy acids also reduce the number of desmosomes and tonofilaments.in this study all patients will be instructed to avoid sun exposure during the treatment and to use broad spectrum sunscreen The treatment was started once daily over the entire face and maintained for two months. A fine layer of face gel was applied on the whole surface where the warts were present, avoiding the eyelids and lips. In children 7 to 10 years of age, face gel was applied by their parents. Clinical controls were performed at Weeks 2, 4, 6, and 8.

Efficacy of Glycolic Acid 15%Plus Salicylic Acid 2% Gel in Treatment of Plane Wart

Evaluation of the efficacy of topical glycolic acid plus salicylic acid in treatment of plane wart.

Response to treatment will be evaluated by the decrease in number or size of plane wart.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Comparison Between Intralesional Injection of Plasma Rich Platelets and Candida Antigen in Plane Warts	NCT05652998	Plane Wart	C. albicans ant... autologous PRP saline	-	South Valley University
Glycolic Acid Plus Salicylic Acid in Treatment of Plane Wart	NCT06233019	Plane Wart	Glycolic Acid P...	6 Years - 17 Years	Assiut University

Spots Global Cancer Trial Database for plane wart

Every month we try and update this database with for plane wart cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for plane wart

Every month we try and update this database with for plane wart cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for plane wart cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.