Diseases and Abnormalities at or Before Birth

All Conditions

Heart and Blood Diseases

Neoplasms

Skin and Connective Tissue Diseases

Congenital Abnormalities

Vascular Malformations

Hemangioma, Capillary

Port-Wine Stain

Hemangioma

Skin Abnormalities

Skin Diseases

Neoplasms, Vascular Tissue

Neoplasms by Histologic Type

Pulsed Dye Laser Treatment 577 nm treatment of Port Wine Stain Birthmarks

Pulsed Dye Laser Treatment 595 nm treatment of Port Wine Stain Birthmarks

Comparison of 577 nm Versus 595 nm Wavelengths of Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks

Pulsed Dye Laser 577 nm

Pulsed Dye Laser 595 nm

John S Nelson, M.D., Ph.D.

Port wine stain are a congenital, progressive vascular malformation of human skin. The pulsed dye laser is approved by the Food and Drug Administration for the treatment of choice. However, the degree of port wine stain blanching seen following pulsed dye laser treatment remains variable and unpredictable. If the ultimate standard required is complete lesion blanching, the average success rate is below 10%, even after undergoing numerous pulsed dye laser treatments. Moreover, less than 50% of patients achieve 50% fading of their Port wine stain in response to pulsed dye laser therapy.

The researchers' specific aim is to determine whether the use of the pulsed dye laser operating at a wavelength of 577 nm will improve therapeutic outcome as compared to a pulsed dye laser operating at 595 nm.

The researcher can treat port wine stain treated using a pulsed dye laser operating at a wavelength of 577 nm and the other half at a wavelength of 595 nm. The researcher can determine that the 577 nm pulsed dye laser improved port wine stain blanching responses more than the areas treated with 595 nm.

The degree of port wine stain blanching which will determine by visible reflectance spectroscopy skin imaging device measurements. Post-treatment blanching responses can compare with pre-treatment measurements of port wine stain fractional blood volume.

Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks: Comparison of 577 nm Versus 595 nm Wavelengths

Beckman Laser Institute University of California Irvine

University of California, Irvine

J.S.Nelson, MD,PhD,Professor of Surgery and Biomedical Engineering

Treatment of Port Wine Stains using Combined Photodynamic and Pulsed Dye Laser

Combined Photodynamic & Pulsed Dye Laser Treatment

Kristen Kelly, MD

This research study was designed to determine the effect on port wine stains (PWS) of liposomal benzoporphyrin derivative monoacid (BPD-MA) termed verteporfin by intravenous (IV) infusion for photodynamic therapy (PDT) or combined PDT and pulsed dye laser (PDL) therapy (PDT + PDL). The standard treatment for PWS is PDL alone. This lightens some PWS but many lesions are not completely removed.

PDT uses a medication and light together to cause injury to a target. The medication is given and then light is directed at the desired area of treatment to achieve an effect. PDT has been used to treat some skin conditions including pre-cancers and skin cancers. Using PDT or PDT immediately followed by PDL therapy may improve PWS lightening. At this time, both PDT and PDT + PDL therapy for treatment of PWS is investigational. The type and amount of medication and light which may be used to treat PWS is not known, and is likely to be different than those used for other PDT treatments.

Procedures will be performed at the Surgery Laser Clinic at the Beckman Laser Institute at the University of California, Irvine.

At an initial visit, a brief history and physical will be performed.

The history will include: 1) previous treatment to my PWS; 2) current medications; 3) history of light sensitivity; 4) risk of pregnancy and use of birth control in a female of child-bearing age.

The physical will include: 1) measurement and evaluation of PWS; 2) measurement of blood pressure, blood cell count, general chemistries (including liver function tests) and ANA, which might indicate an increased sensitivity to light.

On the day of treatment, the same brief physical and history will be repeated. A urine pregnancy test will be performed on females of child-bearing age.

Four circular test sites of PWS will be selected. One test site will receive no treatment. The second test sites will be treated with the pulsed dye laser at standard setting and protective eyeglasses to shield the eyes during the laser treatment.

For two additional test spots, the photodynamic therapy (PDT) verteporfin will be administered intravenously over a 10-minute period. After receiving the verteporfin, the skin and eyes will be sensitive to light for the next 5 days. The light sensitive protection precautions will be instructed.

Optical Doppler Tomography unit (ODT) measurements, similar to shining a flash light to PWS and measuring the light response, which provide information about how blood is flowing through the PWS.

Photographs and light measurements will be taken during follow-up visits on day 1, day 3, and 1, 2, 4, 8 and 12 weeks after the study treatment. At these visits blood may also be drawn to check for blood substances that promote blood vessel formation.

At the end of the study, blood tests will be drawn to assess cell count and general chemistries.

Combined Photodynamic and Pulsed Dye Laser Treatment of Port Wine Stains

Kristen Kelly, M.D., Professor of Dermatology and Surgery

Treatment of Port Wine Stains

Treatment of Port Wine Stains: Treatment of Port Wine Stains

Treatment of Port Wine Stains

Treatment of Port Wine Stains using Combined Photodynamic and Pulsed Dye Laser.

Combined Photodynamic and Pulsed Dye Laser Treatment

Adult over 18

Age, Customized

Sex: Female, Male

Kristen M. Kelly, M.D.

Blanching of Port Wine Stain Birthmark

Treatment of Port Wine Stains: using Combined Photodynamic and Pulsed Dye Laser.

Overall Study

Nevus, Pigmented

Nevus

Pulsed dye laser (Candela), Intense pulsed light (Palomar)

Merete Hædersdal, MD, PhD, DrMedSci

The purpose of the trial is to compare efficacy and adverse effects of pulsed dye laser and intense pulsed light in patients with port wine stains.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks: Comparison of 577 nm Versus 595 nm Wavelengths	NCT00573729	Port Wine Stain...	Pulsed Dye Lase... Pulsed Dye Lase...	6 Months -	University of California, Irvine
Combined Photodynamic and Pulsed Dye Laser Treatment of Port Wine Stains	NCT00556946	Port Wine Stain...	Combined Photod...	18 Years -	University of California, Irvine
Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks: Comparison of 577 nm Versus 595 nm Wavelengths	NCT00573729	Port Wine Stain...	Pulsed Dye Lase... Pulsed Dye Lase...	6 Months -	University of California, Irvine
Treatment of Naevus Flammeus Using Intense Pulsed Light and Pulsed Dye Laser	NCT00365118	Port-Wine Stain	Pulsed dye lase...	2 Years -	Bispebjerg Hospital

Spots Global Cancer Trial Database for port wine stains