Neoplasms

Digestive System Diseases

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Colorectal Neoplasms

Hypersensitivity

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

CRC diagnosed in the population excluded from screening

CRC diagnosed after a positive fecal immunochemical test (FIT)

CRCs diagnosed after a positive fecal immunochemical (FIT) test, but without colonoscopy or \> 2 years after a positive fecal immunochemical test

CRCs diagnosed 2 years after a negative FIT

CRCs diagnosed in the FIT non-responders population

CRCs diagnosed within 5 years after a colonoscopy performed following a positive test that did not find colorectal cancer

We evaluated CRCs screening campaign from January 1, 2016 to December 31, 2017, and interval cancers within two years after a negative test, and five years for post-colonoscopy interval cancers.

Positive fecal immunochemical test (FIT)

Negative fecal immunochemical test (FIT)

Fecal immunochemical test (FIT) not performed

Michel ROBASZKIEWICZ

Fecal immunochemical test (FIT) was introduced in France late 2015, FIT has better diagnostic accuracy for colorectal cancers (CRCs) than previous screening tests. Our primary objective was to evaluate the sensitivity of FIT and the proportion of interval cancer.

Fecal immunochemical test (FIT) aims to detect pre-symptomatic lesions, i.e., early stage colorectal cancers (CRCs) or pre-cancerous lesions such as colonic adenomas in order to reduce CRC mortality. FIT was introduced in France late 2015, FIT has better diagnostic accuracy for CRCs than previous screening tests. Determining the incidence of post-test interval CRCs, diagnosed after a negative FIT and before the recommended date of the next test (2-year interval), allows assessment of the sensitivity of the test. The primary objective of this study was to evaluate the performance of FIT during the CRC screening campaign in the Finistère department (France) from January 1, 2016 to December 31, 2017. Its secondary objectives were the evaluation of diagnostic circumstances and their impact on treatment and survival, and risk factors for interval cancer (IC).

Sensitivity of Fecal Immunochemical Test (FIT) for Colorectal Cancer (CRC) Screening

Sensitivity of Fecal Immunochemical Test (FIT) for Colorectal Cancer (CRC) Screening and Interval Cancer Risk : a Population Based Study

Sensitivity = True positive / True positive + False negative = SD CRCs / SD CRCs + FIT IC

Age, sex, stages, localizations, comparison by Chi2 or Fisher's test for categorical data and Student's test for quantitative data. Multivariate analysis using logistic regression.

FIT value, comprised between 10 and 200 µg haemoglobin/g faeces (analytical limits of quantification),

Analysis of survival according to diagnostic circumstances

Analysis of treatment according to diagnostic circumstances

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Sensitivity of Fecal Immunochemical Test (FIT) for Colorectal Cancer (CRC) Screening	NCT05163236	Colorectal Neop... Colonoscopy Early Detection... Female Mass Screening Middle Aged Occult Blood	Positive fecal ... Negative fecal ... Fecal immunoche...	50 Years - 77 Years	University Hospital, Brest
Sensitivity of Fecal Immunochemical Test (FIT) for Colorectal Cancer (CRC) Screening	NCT05163236	Colorectal Neop... Colonoscopy Early Detection... Female Mass Screening Middle Aged Occult Blood	Positive fecal ... Negative fecal ... Fecal immunoche...	50 Years - 77 Years	University Hospital, Brest

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