Symptoms and General Pathology

All Conditions

Neoplasms

Nervous System Diseases

Behaviors and Mental Disorders

Rare Diseases

Pain, Postoperative

Pain

Acute Pain

Brain Neoplasms

Agnosia

Perceptual Disorders

Neurobehavioral Manifestations

Neurologic Manifestations

Postoperative Complications

Acute Graft Versus Host Disease

Analgesics

Central Nervous System Depressants

All Drugs and Chemicals

Dexmedetomidine

Ropivacaine

Hypnotics and Sedatives

Analgesics, Non-Narcotic

Adrenergic Agents

Adrenergic alpha-Agonists

Adrenergic Agonists

Neurotransmitter Agents

The patients in this group will be received scalp nerve block before surgery with 0.5% ropivacaine. The patients also will be given dexmedetomidine intravenously at a rate of 0.4 μg/kg/h from skin incision until the beginning of dura mater closure, and will be adjusted to 0.05 μg/kg/h for 48 hours after surgery.

The patients in this group will be received scalp nerve block before surgery with 0.5% ropivacaine. For dexmedetomidine placebo group, normal saline will be infused at the same rate as dexmedetomidine during surgery and for 48 hours after surgery.

The patients in this group will not receive scalp nerve block. The patients will be given dexmedetomidine intravenously at a rate of 0.4 μg/kg/h from skin incision until the beginning of dura mater closure, and will be adjusted to 0.05 μg/kg/h for 48 hours after surgery.

The patients in this group will not receive scalp nerve block before surgery . For dexmedetomidine placebo group, normal saline will be infused at the same rate as dexmedetomidine group during surgery and for 48 hours after surgery.

The 200ug dexmedetomidine will be diluted into a 50ml syringe and administered with 0.4ug/kg/h intraoperatively and 0.05 μg/kg/h for 48 hours after surgery.

In the placebo group, the 0.9% saline is administered with the same volume at the same speed as the dexmedetomidine group

Normal saline

The 10ml 1% ropivacaine will be diluted into a 20ml syringe . As for scalp nerve block, each nerve will be blocked separately with 1-2 mL 0.5% ropivacaine.

Local analgesic techniques

No Local analgesic techniques will be given.

no Local analgesic techniques

Yuming Peng, Dr

Min Zeng, Dr

Supratentorial craniotomy is one of the most common neurosurgical procedures, with severe perioperative pain. Inadequate perioperative pain relief has been associated with increased blood pressure and intracranial pressure, favoring bleeding and cerebral cerebral hypoperfusion. The ideal analgesia for neurosurgery requires complete pain relief, eliminates the side effects of opioid drugs and no influence for neurological function. Previous studies have proposed a multimodal analgesic strategy, combining analgesics and local anaesthesia, it is expected to achieve the above benefits.

The trial has been designed to analyze the efficacy of local analgesic techniques and dexmedetomidine in the treatment of postoperative acute pain in craniotomy. This randomized clinical trial aims to enroll 2000 patients, which will be randomized to one of 4 groups.

Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy

Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy：a 2× 2 Factorial Randomized Clinical Trial

Cumulative amount of sufentanil used by patient-controlled analgesia (PCIA) in patients within 48 hours postoperatively.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy	NCT06406829	Postoperative P... Analgesia Supratentorial ...	Dexmedetomidine Normal saline Local analgesic... no Local analge...	18 Years - 65 Years	Beijing Tiantan Hospital
Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy	NCT06406829	Postoperative P... Analgesia Supratentorial ...	Dexmedetomidine Normal saline Local analgesic... no Local analge...	18 Years - 65 Years	Beijing Tiantan Hospital

Spots Global Cancer Trial Database for postoperative acute pain