Spots Global Cancer Trial Database for Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy

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Trial Identification

Brief Title: Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy

Official Title: Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy：a 2× 2 Factorial Randomized Clinical Trial

Study ID: NCT06406829

Conditions

Postoperative Pain

Analgesia

Supratentorial Brain Tumor

Interventions

Dexmedetomidine

Normal saline

Local analgesic techniques

no Local analgesic techniques

Study Description

Brief Summary: Supratentorial craniotomy is one of the most common neurosurgical procedures, with severe perioperative pain. Inadequate perioperative pain relief has been associated with increased blood pressure and intracranial pressure, favoring bleeding and cerebral cerebral hypoperfusion. The ideal analgesia for neurosurgery requires complete pain relief, eliminates the side effects of opioid drugs and no influence for neurological function. Previous studies have proposed a multimodal analgesic strategy, combining analgesics and local anaesthesia, it is expected to achieve the above benefits.

Detailed Description: The trial has been designed to analyze the efficacy of local analgesic techniques and dexmedetomidine in the treatment of postoperative acute pain in craniotomy. This randomized clinical trial aims to enroll 2000 patients, which will be randomized to one of 4 groups.