Neoplasms

All Conditions

Symptoms and General Pathology

Skin and Connective Tissue Diseases

Leiomyoma

Hemorrhage

Postoperative Complications

Myofibroma

Blood Loss, Surgical

Postoperative Hemorrhage

Myoma

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Neoplasms, Connective Tissue

Connective Tissue Diseases

Intraoperative Complications

Coagulants

All Drugs and Chemicals

Central Nervous System Depressants

Psychotropic Drugs

Gastrointestinal Agents

Reproductive Control Agents

Tranexamic Acid

Tranylcypromine

Misoprostol

Antifibrinolytic Agents

Hemostatics

Antacids

Anti-Ulcer Agents

Antidepressive Agents

Monoamine Oxidase Inhibitors

Enzyme Inhibitors

Anti-Anxiety Agents

1. Patients' postoperative 1st, 2nd, and 6th-hour vital signs (pulse rate, systolic and diastolic blood pressure, temperature, oxygen saturation).
2. Shock indices.
3. Hemogram and hematocrit values at 6-24 hours postoperatively.
4. Duration of the surgery.
5. Adverse effects experienced by the patients.
6. Additional treatments administered.
7. Whether blood transfusion was performed or not.

the admistiration of 400 Mcg rectal cytotec while starting the surgery, just before the patient is covered

Cytotec 200Mcg Tablet

1 gram intravenous slow infusion intraoperatively as we start the laparatomy

Transamine

Fibroids are the most commonly encountered tumors in the female reproductive system. In patients, fibroids most often lead to abnormal uterine bleeding and the resulting anemia. In some cases, they can cause infertility or habitual abortions. Another complaint caused by fibroids is pain due to pressure and effects on adjacent organs. Very large fibroids can lead to abdominal swelling. Therefore, if a patient becomes symptomatic due to fibroids, myomectomy or, if necessary, hysterectomy is required.

Because fibroids have a significant blood supply, there is a high risk of intraoperative bleeding and related complications. Additionally, the most common complication in these patients after the operation is bleeding. In many of these patients, intraoperative or postoperative blood transfusions are performed. If bleeding cannot be intervened early in these patients, hemodynamic instability, shock, coagulopathy, and, in the final stage, death can occur due to hemorrhage. Therefore, both intraoperative and postoperative bleeding control is of vital importance in patients undergoing myomectomy.

In this study, data of patients admitted with a diagnosis of uterine fibroids to the Department of Obstetrics and Gynecology, Women's Health and Obstetrics (EŞH) between September 1, 2022, and Sempember 1, 2024, who underwent myomectomy (either laparotomic or laparoscopic), will be collected.

The parameters to be examined in the research are as follows:

1. Patients' postoperative 1st, 2nd, and 6th-hour vital signs (pulse rate, systolic and diastolic blood pressure, temperature, oxygen saturation).
2. Shock indices.
3. Hemogram and hematocrit values at 6-24 hours postoperatively.
4. Duration of the surgery.
5. Adverse effects experienced by the patients.
6. Additional treatments administered.
7. Whether blood transfusion was performed or not.

In this study, the G-power analysis program was used to determine the minimum sample size, taking into account a 10% margin of error. According to the analysis results, the minimum number of patients to be included in the study for a total of 75 patients across 3 groups was determined. Statistical analysis of the data obtained in the study will be conducted using the SPSS Statistics 22 software package. A 95% confidence interval will be calculated for each variable, and results will be considered statistically significant for p \< 0.05.

Comparison Effectiveness of Rectal Misoprostol & Intravenous Tranexamic Acid Reducing Hemorrhage in Myomectomy

The Comparison of the Effectiveness of Rectal Misoprostol and Intravenous Tranexamic Acid in Reducing Intraoperative Bleeding in Patients Undergoing Myomectomy

The basal hemogram levels ( gr/dL) of the patients will be compared with the hemogram levels at 6 and 24 hours.

The basal hematocrit levels (%) of the patients will be compared with the hematocrit levels at 6 and 24 hours.

postoperative 1st, 2nd, and 6th-hour shock indices (heart rate (beats in minute) / systolic blood pressure(mmHg) ) will be compared

Patients postoperative 1st, 2nd, and 6th-hour heart rate (beats in minute) will be compared

Patients postoperative 1st, 2nd, and 6th-hour systolic and diastolic blood pressure (mmHg) will be compared

Ankara Etlik City Hospital

clinical doctor

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Urinary Bladder Neoplasms

Anti-Infective Agents

Amino Acids

Aprotinin

Trypsin Inhibitors

Protease Inhibitors

Serine Proteinase Inhibitors

HIV Protease Inhibitors

Serine

Subjects will be randomized to receive an infusion of aprotinin (a test dose followed by a loading dose of 2 million KIU before skin incision followed by 500,000 KIU/hour until the end of surgery) or matching placebo. The maximal dose of aprotinin, that can be administered is 7,000,000 KIU, regardless of the duration of the operation. When a total of 7 million has been reached the administration of aprotinin must be discontinued.

Trasylol (Aprotinin, BAYA0128)

Placebo is used according to the description of Arm 1

Placebo

Bayer Study Director

The purpose of this study is to assess if aprotinin (BAYA0128), given intravenously during your surgery, is safe and can help reduce the need for a blood transfusion during bladder surgery.

Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total Cystectomy

A Multi-center, Randomized, Double Blind, Placebo Controlled Study to Investigate the Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients With Bladder Cancer Undergoing Radical or Total Cystectomy.

Bayer

Breast Neoplasms

Seroma

Breast Diseases

Skin Diseases

Inflammation

tranexamic acid to be smeared on surgical wounds before closure

saline to be smeared on surgical wounds before closure

moisten the surgical wound surface with 20 ml tranexamic acid 25 mg/ml

moisten the surgical wound surface with 20 ml placebo (0.9% saline)

saline

Petter Aadahl, MD PhD

Sverrir Olafsson

After surgical procedures, interventions to reduce postoperative bleeding are of great importance. In this study, the effect will be investigated of smearing tranexamic acid, which is designed for injection, directly onto the raw wound surface (topical application) created during surgery. Topical application allows a small amount of drug to reach a large wound area, higher drug concentration in the exposed wound surface but very low concentration in the body, and no risk of injury from needles. The researchers have recently shown that topically applicated tranexamic acid reduces bleeding in women who had two-sided breast reduction surgery. Now it will be studied whether topically applicated tranexamic acid reduces bleeding after breast surgery for breast cancer.

After surgery for breast cancer patients may also experience problems with long lasting seroma. Therefore it will at the same time be investigated whether topical tranexamic acid reduces the development of seroma in these patients.

The Effect of Topical Tranexamic Acid on Bleeding and Seroma Formation in After Undergoing Mastectomy

The Effect of Topical Administration of Tranexamic Acid on Postoperative Bleeding and Seroma Formation in Patients Undergoing Mastectomy: A Prospective Placebo-controlled Double Blinded Randomized Study

Drains are placed in surgical wounds during operation, and amount of blood on drains measured in ml

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Comparison Effectiveness of Rectal Misoprostol & Intravenous Tranexamic Acid Reducing Hemorrhage in Myomectomy	NCT06114758	Hemorrhage, Sur... Myoma;Uterus Effect of Drug Postoperative H... Postoperative C...	Cytotec 200Mcg ... Transamine	18 Years - 45 Years	Ankara Etlik City Hospital
Comparison Effectiveness of Rectal Misoprostol & Intravenous Tranexamic Acid Reducing Hemorrhage in Myomectomy	NCT06114758	Hemorrhage, Sur... Myoma;Uterus Effect of Drug Postoperative H... Postoperative C...	Cytotec 200Mcg ... Transamine	18 Years - 45 Years	Ankara Etlik City Hospital
Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total Cystectomy	NCT00306150	Blood Loss, Sur... Postoperative H...	Trasylol (Aprot... Placebo	18 Years -	Bayer
Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total Cystectomy	NCT00306150	Blood Loss, Sur... Postoperative H...	Trasylol (Aprot... Placebo	18 Years -	Bayer
The Effect of Topical Tranexamic Acid on Bleeding and Seroma Formation in After Undergoing Mastectomy	NCT02627560	Postoperative H... Breast Neoplasm... Seroma	Tranexamic Acid saline	18 Years -	St. Olavs Hospital

Spots Global Cancer Trial Database for postoperative hemorrhage