Neoplasms

All Conditions

Rare Diseases

Liposarcoma

Liposarcoma, Myxoid

Neoplasms, Adipose Tissue

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Sarcoma

Myxoid Liposarcoma

Soft Tissue Sarcoma

MLS patients receiving preoperative RT to a dose of 36 Gy (equivalent) followed by surgery

MLS patients receiving preoperative RT to a dose of 50 Gy (equivalent) followed by surgery

MLS patients receiving surgery followed by postoperative RT to a dose of 50-66 Gy (equivalent)

MLS patients with oligometastatic and/or oligoprogressive disease receiving definitive RT to a dose of 36Gy (equivalent)

Surgery

Preoperative radiotherapy to 36Gy (equivalent)

Preoperative RT 36Gy

Preoperative radiotherapy to 50Gy (equivalent)

Preoperative RT 50Gy

Postoperative radiotherapy to 50-66Gy (equivalent)

Postoperative RT 50-66Gy

Definitive radiotherapy to 36Gy (equivalent)

RT 36Gy

Rick Haas, MD/PhD

Jules Lansu, MD/PhD

To prospectively study commonly used local treatment approaches in Myxoid Liposarcoma (MLS)

In order to confirm the promising results of the 36 Gy dose level in the DOREMY trial (NCT02106312) and to compare outcome with other local treatment approaches.

International Prospective Registry on Local Treatment Approaches in MLS

International Prospective Registry on Local Treatment Approaches in Myxoid Liposarcomas

PRO-CTCAE Item Library; relevant questions from the Patient-Reported Outcomes version of the CTCAE (PRO-CTCAE)

EORTC QLQ-C30; 30-item HRQoL questionnaire; EORTC Items Library; 3 questions to assess some radiotherapy-specific HRQoL; EQ5D-5L; descriptive system for measurement of health; iMCQ; relevant items from the Medical Consumption Questionnaire (iMCQ) to assess medical consumption; PRODISQ; PROductivity and DISease Questionnaire to assess all relevant aspects of the relationship between health and productivity;

Survival from surgery to local recurrence (event) or last follow-up

Any wound complication requiring intervention

Any grade ≥2 late (radiation-induced) toxicity according to CTCAE v5.0 toxicity criteria

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
International Prospective Registry on Local Treatment Approaches in MLS	NCT04699292	Myxoid Liposarc...	Surgery Preoperative RT... Preoperative RT... Postoperative R... RT 36Gy	18 Years -	The Netherlands Cancer Institute
International Prospective Registry on Local Treatment Approaches in MLS	NCT04699292	Myxoid Liposarc...	Surgery Preoperative RT... Preoperative RT... Postoperative R... RT 36Gy	18 Years -	The Netherlands Cancer Institute

Spots Global Cancer Trial Database for preoperative rt 50gy