Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

SLN is identified using gamma probe and ultrasound. Percutaneous wire placement carried out to mark SLN for subsequent surgical verification.

Preoperative sentinel lymph node identification and marking

When a person has breast cancer it is necessary to find out whether the cancer has spread to the lymph nodes in the armpit because if it has, further treatment is likely to be needed. There are many of these nodes but when the breast cancer spreads, it does so in a step-by-step fashion, starting with the so-called Sentinel Lymph Node (SLN). At present, the only way to be sure whether there is cancer in the lymph nodes or not is to perform an operation to remove at least the SLN. If the pathologist finds cancer in the SLN, a second operation is usually required to remove further nodes in case they contain cancer too. Surgical removal of the lymph nodes in the armpit can cause difficulties for the patient afterwards, such as pain and swelling in the arm. If there is no cancer in the SLN, no further operations on the armpit are needed. The investigators wish to find out whether in some patients, operations on the armpit can be avoided completely. The first step in doing this is to test whether the investigators can find out which is the SLN before the operation, using a combination of an injection and ultrasound scanning. The injection - into the skin of the breast - would be a radioactive substance, which is the usual way the surgeon finds the SLN. The radioactive substance collects in the SLN and the investigators would use a "gamma probe" over the surface of the armpit to detect the radiation. In this initial study, the investigators would aim to find the SLN before the operation and place a marker wire in it so that the surgeon could check whether the investigators had found the correct node.

Preoperative Localisation of the Sentinel Lymph Node in Breast Cancer

Preoperative Identification of the Sentinel Lymph Node in Breast Cancer, Using Ultrasound and Radio-isotope/Percutaneous Gamma Probe

University of Dundee

NHS Tayside

Professor of Breast Imaging

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Preoperative Localisation of the Sentinel Lymph Node in Breast Cancer	NCT01154972	Breast Cancer	Preoperative se...	-	NHS Tayside
Preoperative Localisation of the Sentinel Lymph Node in Breast Cancer	NCT01154972	Breast Cancer	Preoperative se...	-	NHS Tayside
Preoperative Localisation of the Sentinel Lymph Node in Breast Cancer	NCT01154972	Breast Cancer	Preoperative se...	-	NHS Tayside
Preoperative Localisation of the Sentinel Lymph Node in Breast Cancer	NCT01154972	Breast Cancer	Preoperative se...	-	NHS Tayside

Spots Global Cancer Trial Database for preoperative sentinel lymph node identification and marking