Neoplasms

Digestive System Diseases

Gland and Hormone Related Diseases

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Symptoms and General Pathology

Rare Diseases

Pancreatic Neoplasms

Pleural Effusion

Stomach Neoplasms

Ovarian Neoplasms

Carcinoma, Ovarian Epithelial

Ascites

Pleural Diseases

Mesothelioma

Mesothelioma, Malignant

Peritoneal Neoplasms

Pseudomyxoma Peritonei

Gallbladder Neoplasms

Appendiceal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Intestinal Diseases

Endocrine Gland Neoplasms

Endocrine System Diseases

Adenoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Neoplasms, Mesothelial

Respiratory Tract Diseases

Pancreatic Diseases

Biliary Tract Neoplasms

Biliary Tract Diseases

Gallbladder Diseases

Adenocarcinoma

Adenocarcinoma, Mucinous

Carcinoma

Neoplasms, Cystic, Mucinous, and Serous

Cecal Neoplasms

Cecal Diseases

Pancreatic Cancer

Ovarian Cancer

Stomach Cancer

Ovarian Epithelial Cancer

Gallbladder Cancer

Malignant Mesothelioma

Antineoplastic Agents

All Drugs and Chemicals

Pharmaceutical Solutions

Gemcitabine

Paclitaxel

Albumin-Bound Paclitaxel

Oxaliplatin

Doxorubicin

Liposomal doxorubicin

Cisplatin

Mitomycins

Mitomycin

A chemotherapeutic solution is aerosolized into the expanded abdominal cavity during laparoscopy, under pressure. This allows a relatively homogeneous repartition of the drug and an effective tissue penetration.

PIPAC

Sabine Rhode

Laura Lay, MD

Craig Lynch, MD

Tarkan Jäger, MD

Woulter Willaert, MD

Martin Graversen, MD

Catherine Arvieux, MD

Clarisse Eveno

Olivier Glehen, MD

Olivia Sgarbura, MD

Verena Schlaich

Marco Vaira, MD

Maciej Nowacki, MD

Vladimir Khomyakov, MD

Janelle Phua

Juan Torrent, MD

Martin Huebner, MD

Philipp Horvath, MD

Multicentric, international, web-based prospective documentation of the indications and results of Pressurized Aerosol Chemotherapy (so-called PIPAC or PITAC) for treating malignant pleural and peritoneal diseases. Indication is decided by the treating physician. There are no predefined inclusion or exclusion criteria.

All data entered into the registry documenting the patient cohort characteristics (disease, demography, therapy) are analyzed using descriptive statistics. Survival data are analyzed with Kaplan-Meier statistics. Multivariate Cox Proportional Hazard Models are used to identify potential prognostic and predictive factors. In particular, a risk- adjusted comparison of the outcome criteria with a propensity score is planned.

The data are stored in a SQL-based online database. Patient data are pseudoanonymized. The registry has received approval of the data protection officer of the State of Northrhine-Westphalia.

The study steering committee is blinded towards the identity of the participating institutions. Each participating institution receives an annual report with own data vs. benchmark. Scientific analysis can be proposed by the steering committee, by a participating institution or by other scientists, subjected to the approval of the independent scientific advisory board.

An export function has been built in to allow data exchange with the HIPEC Registry of the German Society for General and GI surgery (http://www.dgav.de/studoq/studoqhipec.html).

International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)

Multicenter, International Online Documentation of Indications and Results of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC Und PITAC) for Treating Malignant Peritoneal and Pleural Diseases

Requests can be addressed to the Scientific Advisory Board, AnInstitut für Qualitässicherung in der operativen Medizin gGmbH, Leipziger Str. 44, 39120 MAGDEBURG, Germany

according to RECIST criteria (CR + PR + SD)

according to the Peritoneal Regression Grading Score (PRGS)

Ruhr University of Bochum

Coordinator

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)	NCT03210298	Peritoneum Canc... Peritoneum Neop... Pleural Cancer Pleural Effusio... Pleural Mesothe... Ovarian Cancer Gastric Cancer Appendix Cancer Pseudomyxoma Pe... Colorectal Canc... Pancreas Cancer Gallbladder Can... Ascites CUP Chemotherapeuti...	PIPAC	10 Years -	University of Magdeburg
International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)	NCT03210298	Peritoneum Canc... Peritoneum Neop... Pleural Cancer Pleural Effusio... Pleural Mesothe... Ovarian Cancer Gastric Cancer Appendix Cancer Pseudomyxoma Pe... Colorectal Canc... Pancreas Cancer Gallbladder Can... Ascites CUP Chemotherapeuti...	PIPAC	10 Years -	University of Magdeburg

Spots Global Cancer Trial Database for pressurized intrathoracic aerosol chemotherapy