Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Breast Neoplasms

Breast Diseases

Skin Diseases

peroperative scintillating probe

operative gamma camera

Carole Mathelin, MD

This project consists on the realization followed by the clinical validation of two medical instruments dedicated to the precise sentinel lymph nodes identification and localization in the case of breast cancer: an intra operative probe and an operative mini gamma camera. The sentinel lymph node technique, based on the propagation of cancer cells in the lymphatic system, allows a better evaluation of tumor staging, prognosis and therapeutic strategy determination. The goal of these instruments designed by physicians and physicists is to significantly improve the detection efficiency of the technique in order to reduce the false negative rate and then the recurrence risk, as well as the operative morbidity.Clinical oncologist surgeons and fundamental physics applied to medical imaging researchers are involved in this project. The clinical validation of the medical instruments will be organized in the Gynaecologic and Obstetric department of the Hospices Civils de Strasbourg with a series of 25 patients in the framework of a regular french protocol of clinical research.

Evaluation of Two New Medical Instruments Dedicated to the Sentinel Lymph Node Technique in Case of Breast Cancer

Sentinel Lymph Node Identification in Case of Breast Cancer. Clinical Evaluation of a New Intra-operative Probe and a Mini Gamma Camera

Centre National de la Recherche Scientifique, France

Louis Pasteur University, Strasbourg

Institut Pluridisciplinaire Hubert Curien, Strasbourg

University Hospital, Strasbourg, France

All Drugs and Chemicals

Methylene Blue

Enzyme Inhibitors

Methylene blue (1%)

Rhenium sulfure

Surgical procedure

Anatomo-pathologic procedure

Jean-Pierre Bellocq, MD

The aim of this study is to evaluate the performance of a double labelling method using isotope and methylene blue dye injection to localize precisely Sentinel Lymph Node (SLN) in a series of 100 patients with infiltrative breast cancer justifying SLN excision. Method and patients: SLN excision will be performed on 100 patients treated for infiltrative breast cancer. After preoperative methylene blue dye injection and lymphoscintigraphy, individual localization of the radioactive and stained nodes will be performed. After the surgery, SLN will be submitted to serial analysis and immunohistochemistry. A comparison of the two methods and an economical evaluation of the complete procedure will be performed.

Identification of Sentinel Lymph Nodes With Methylene Blue and Isotope

Identification of Sentinel Lymph Node (SLN) in Breast Cancer Care: Clinical and Economical Evaluation of a Double Method Using Isotope and Methylene Blue Dye Injection.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of Two New Medical Instruments Dedicated to the Sentinel Lymph Node Technique in Case of Breast Cancer	NCT00357487	Breast Cancer	peroperative sc... operative gamma...	18 Years -	University Hospital, Strasbourg, France
Identification of Sentinel Lymph Nodes With Methylene Blue and Isotope	NCT00314405	Infiltrative Br...	Methylene blue ... Rhenium sulfure Surgical proced... Anatomo-patholo...	18 Years -	University Hospital, Strasbourg, France
Identification of Sentinel Lymph Nodes With Methylene Blue and Isotope	NCT00314405	Infiltrative Br...	Methylene blue ... Rhenium sulfure Surgical proced... Anatomo-patholo...	18 Years -	University Hospital, Strasbourg, France
Evaluation of Two New Medical Instruments Dedicated to the Sentinel Lymph Node Technique in Case of Breast Cancer	NCT00357487	Breast Cancer	peroperative sc... operative gamma...	18 Years -	University Hospital, Strasbourg, France

Spots Global Cancer Trial Database for probe

Every month we try and update this database with for probe cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for probe

Every month we try and update this database with for probe cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for probe cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.