Neoplasms

Musculoskeletal Diseases

All Conditions

Bone Neoplasms

Dermatologic Agents

All Drugs and Chemicals

Benzoyl Peroxide

All the patients operated on Van Nes Rotationplasty for bone tumors at IOR and long term surviving

Pelvic coronal X-ray, proprioceptive test with Delos system, questionnaires administration, orthopaedic, physiatric and prosthetic assessment

Assessment

Maria Grazia Benedetti

Rotationplasty is a very special surgical technique. In its most frequent variant it allows, in the bone sarcomas of the distal femur, to remove all the thigh tissues including the knee joint keeping intact the innervation of the leg and the foot that are transplanted proximally after a 180 ° rotation and joined to the proximal femoral stump.

It is currently the first choice in children under the age of 6 with a bone sarcoma localized to the distal femur but also finds indication in all age groups in cases of extremely voluminous and extended to the entire thigh with the oncological need to remove in block femur, knee and all the muscular involved. The objective of the study is to obtain information about the clinical and functional status of the limb operated in long-term surviving patients. In particular in this study the problem of the possible degenerative pathology of the hip on the operated side will be addressed. Moreover the psychic and psychological well-being of this population with particular reference to gender and motherhood will be tested.

30 long term survivors of rotationplasty patients at the IOR will be welcomed by the research team. They will be introduced to the aims of the research and the methodology and timing of the assessment.

The two-day agenda will be communicated to perform in a coordinated manner so that each patient performs all the exams:

* X ray pelvis
* Physiatric, orthopedic and prosthetic examination
* Proprioceptive test with Delos system
* Psychological questionnaires

Long Term Clinical and Functional Outcome in Rotationplasty Patients

Long Term Clinical and Functional Outcome in Patients Operated on Van Ness-Borggreve Rotationplasty for Lower Limnb Bone Tumor

Psychological Well-being Scales The Italian validated version, Review of Psychiatry, 2003, 38, 3, pp.117-130) will be used. The reduced version from the 18-item test (3 items for each of the 6 dimensions of psychological well-being) will be used. Each item is assigned a score variable from 1 (= it is not my case / I do not agree) to 6 (= it is just so / perfectly agree). Some items are expressed in negative form and therefore in scoring the score assigned by the subject must be reversed. Adding the scores of the triplets you get a score for each of the 6 dimensions / subscales: autonomy, environmental control, positive relationships with others, self-acceptance, purpose in life and personal growth. Instead, the sum of the value of all 18 items gives an overall value of psychological well-being. At higher scores there is a higher level of well-being (both general and specific for each of the 6 measured dimensions).

Rosenberg Self-Esteem Scale The version translated and validated in Italian by Professor Miretta Prezza of the University of Florence (Bulletin of Applied Psychology, 1997, 223, 35-44) will be used. It measures the attitude towards oneself through 10 items, to which the subject must respond by assigning a score from 1 (strongly disagree) to 4 (strongly agree) The scores of the negative items are reversed. The total score, obtained by adding the scores of the individual items, at higher values corresponds to an attitude more positive towards oneself.

Amputees Body Image Scale by James W. Breakey published in the Journal of Prosthetics and Orthotics (Volume 9, Number 2 / Spring 1997).

It has never been translated and validated in Italian, it has been translated and adapted (to amputation + gyroplasty) for this study.

It evaluates the disturbance in the perception of the body image on a frequency scale (from ever to ever) to 5 points ((1 = never; 5 = always) .It consists of 20 items (3 of which are expressed in 'positive' and therefore to be counted by inverting the score.) The scale gives an overall value (obtained by adding the score of all the items), which goes from 20 to 100: at higher scores there is a greater problematic in the perception of one's body image.

Istituto Ortopedico Rizzoli

MD Director Physical Medicine and Rehabilitation Unit

Behaviors and Mental Disorders

Stress, Psychological

Behavioral Symptoms

Quality of Life

Participants in this group will receive the Cognitive Behavioral Therapy (CBT)-based skills over a 10-week period.

Participants in this group will receive standard education.

The CBT skills target reducing anxiety, (e.g., relaxation), changing negative appraisals (e.g., cognitive restructuring), coping skills training (e.g., enhancing adaptive skills), behavioral activation, interpersonal skills (e.g., communication skills) and building or enhancing social networks. The intervention will be administered online, and each module will last about 1-hour.

Cognitive Behavioral Therapy (CBT)-based skills

Patients randomized to standard clinical care will receive standard education based on various resources (e.g., National Cancer Institute) relevant to pancreatic cancer.

Standard Education

Sara Fleszar-Pavlovic, PhD

Frank Penedo

Frank Penedo, PhD

The purpose of this research is to evaluate a new, web-based program among patients with pancreatic cancer aimed at reducing psychosocial stress.

QOL and GI Outcomes in Malignancies

Psychosocial Determinants of Health-Related Quality of Life (QOL) and Gastrointestinal (GI) Functional Outcomes During Treatment for Malignancies

Perceived Stress Scale (Scale of 1-40 with higher scores indicating higher stress)

UCLA Loneliness Scale (Scale of 20-80 with higher scores indicating higher loneliness)

Interpersonal Support Evaluation List (12 item questionnaire evaluated on a 4-point Likert scale with a higher score indicating higher support).

FACT-G7 (Scale of 0-28 with higher scores indicating better quality of life)

FACT FHSI-18 (Scale of 0-72 with lower scores indicating better quality of life)

GSRS (Scale of 0-78 with higher scores indicating worse gastrointestinal symptoms)

University of Miami

Professor

Skin and Connective Tissue Diseases

Breast Neoplasms

Breast Diseases

Skin Diseases

Mothers and their children (age 0-16) take part in a 3-week, family-oriented oncological rehabilitation programme which consists of medical, psychological and psychooncological treatments for mothers and children.

rehabilitation programme "getting better together"

Fritz Mattejat, PhD

Katja J John, DP (MA)

About 1/3 of newly diagnosed breast cancer patients are mothers of children who still live at home. They face additional challenges and stress, their children are also affected by the mother's illness. The oncological rehabilitation programme "getting better together" focuses on these special family needs. This waiting-control-group study examines the effectiveness of the intervention by accompanying the patients and their children over the course of a year and assessing their quality of life and psychological health.

About 1/3 of newly diagnosed breast cancer patients are mothers of children who still live at home. They face additional challenges and stress, their children are also affected by the mother's illness. The oncological rehabilitation programme "getting better together", administered by the Rexrodt von Fircks Foundation and the Clinic Ostseedeich in Groemitz, Germany, focuses on these special family needs. This waiting-control-group-study, designed and executed at the Philipps University Marburg Medical Center, Department of Child and Adolescent Psychiatry, examines the effectiveness of the intervention by accompanying the patients and their children over the course of a year and assessing their quality of life and psychological health.

The primary outcome measure for mothers is the health related quality of life as assessed by the EORTC QLQ-C30 and BR-23; children's adaptation is assessed with the ILK (Inventory for the Assessment of Quality of Life of Children and Adolescents) as well as the Strengths and Difficulties Questionnaire (SDQ)

Impact of a Rehabilitation Programme for Mothers With Breast Cancer and Their Children

Impact of a Family-oriented Rehabilitation Programme for Mothers With Breast Cancer and Their Children - Quality of Life and Psychological Health of Mothers and Their Children

Dept. of Child and Adolescent Psychiatry, Philipps University Marburg

Rexrodt von Fircks Foundation

Philipps University Marburg Medical Center

Psychoeducation, provision of medical knowledge, coping skills training

Brief psychological intervention

Markus A Landolt, PhD

The purpose of the study is to evaluate the effectiveness of a two-session brief psychological intervention in siblings of pediatric cancer patients with regard to behavior problems and depression.

Within a randomized controlled design the effects of a brief two-session psychological intervention (child, parents) shall be studied in 30 siblings of newly diagnosed pediatric cancer patients. After a baseline assessment 3-4 weeks after diagnosis participants are randomly assigned to an intervention or waiting list group. Both are re-assessed at 3 and 6 months by means of standardized questionnaires assessing psychological adaptation and behavior. The intervention is provided to the waiting list group after the 6-month assessment.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Long Term Clinical and Functional Outcome in Rotationplasty Patients	NCT03385694	Disability Phys... Psychological A...	Assessment	-	Istituto Ortopedico Rizzoli
QOL and GI Outcomes in Malignancies	NCT04815746	Psychological A... Psychological A... Stress, Emotion...	Cognitive Behav... Standard Educat...	18 Years -	University of Miami
Impact of a Rehabilitation Programme for Mothers With Breast Cancer and Their Children	NCT00916825	Breast Cancer	rehabilitation ...	-	Philipps University Marburg Medical Center
QOL and GI Outcomes in Malignancies	NCT04815746	Psychological A... Psychological A... Stress, Emotion...	Cognitive Behav... Standard Educat...	18 Years -	University of Miami
Psychological Interventions in Siblings of Children With Cancer	NCT00296907	Cancer	Brief psycholog...	7 Years - 16 Years	University Children's Hospital, Zurich
Impact of a Rehabilitation Programme for Mothers With Breast Cancer and Their Children	NCT00916825	Breast Cancer	rehabilitation ...	-	Philipps University Marburg Medical Center
QOL and GI Outcomes in Malignancies	NCT04815746	Psychological A... Psychological A... Stress, Emotion...	Cognitive Behav... Standard Educat...	18 Years -	University of Miami
QOL and GI Outcomes in Malignancies	NCT04815746	Psychological A... Psychological A... Stress, Emotion...	Cognitive Behav... Standard Educat...	18 Years -	University of Miami

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