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2 Hz EA during 30 minutes, twice a week, 14 weeks.

Low-frequency electro-acupuncture (EA)

Meeting a therapist, twice a week during 30 minutes in order to control for the increased amount of attention.

Meeting a therapist - attention control

Hypothesis The overall hypothesis is that non-obese (BMI \<30) women with PCOS have high luteinising hormone (LH) and cortisol pulse frequency and amplitude and that repeated low-frequency EA restore these alterations and induce ovulation.

Aim 1. Elucidate if low-frequency EA induce ovulation and restore LH frequency and amplitude as well as sex steroid secretion as compared to a control group receiving same amount of attention.

Aim 2. Elucidate if low-frequency EA restore cortisol frequency and amplitude compared to a control group receiving same amount of attention.

Aim 3. Elucidate if low-frequency EA restore psychological distress and quality of life as compared to a control group receiving same amount of attention.in women with PCOS.

Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome

Does Low-frequency Electro-acupuncture Restore Sensitivity of the Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome

Göteborg University

Nutritional and Metabolic Diseases

Obesity

Metabolic Syndrome

Insulin Resistance

Hypoglycemic Agents

Androgens

Insulin

Insulin, Globin Zinc

Electroacupuncture

Physical exercise

Untreated control

Elisabet Stener-Victorin, Prof, PhD

Hypothesis:

The overall hypothesis is that women with PCOS, both obese and non-obese, have larger adipocytes, altered metabolism and signs of inflammation in adipose tissue and that these changes are associated with high sympathetic nerve activity, hyperandrogenism hyperinsulinaemia, insulin resistance with progression to type II diabetes and cardiovascular disease (CVD) as well as psychological distress and reduced quality of life. Physical exercise and electro-acupuncture decrease high concentrations of androgens, induce regulare menstrual pattern, inhibits high sympathetic activity and restore the PCOS induced disturbances.

Primary outcome: Changes in androgen concentrations and menstrual pattern

Secondary outcome: changes in sympathetic nerve activity, uterus peristalsis, ovarian morphology, adipose tissue related variables, insulin sensitivity, coagulation factors and health related quality of life and symptoms of anxiety and depression.

Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture

Polycystic Ovary Syndrome (PCOS) - The Female Metabolic Syndrome Genes And Processes In The Aetiology And Pathogenesis Of PCOS And Identification Of New Treatment Strategies

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome	NCT00921492	Polycystic Ovar...	Low-frequency e... Meeting a thera...	18 Years - 39 Years	Göteborg University
Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture	NCT00484705	Polycystic Ovar...	Electroacupunct... Physical exerci... Untreated contr...	18 Years - 37 Years	Göteborg University
Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome	NCT00921492	Polycystic Ovar...	Low-frequency e... Meeting a thera...	18 Years - 39 Years	Göteborg University

Spots Global Cancer Trial Database for psychological distress and quality of life