Neoplasms

Heart and Blood Diseases

Blood and Lymph Conditions

Immune System Diseases

All Conditions

Rare Diseases

Multiple Myeloma

Neoplasms, Plasma Cell

Neoplasms by Histologic Type

Hemostatic Disorders

Blood Coagulation Disorders

Vascular Diseases

Paraproteinemias

Blood Protein Disorders

Hematologic Diseases

Hemorrhagic Disorders

Lymphoproliferative Disorders

Immunoproliferative Disorders

Relapse/refractory multiple myeloma/RRMM patients less than 70 years of age.

Relapse/refractory multiple myeloma/RRMM patients 70 years of age or greater

Physicians in this group refer for cellular therapy but do not perform the infusions.

These physicians can order and infuse CAR T cells but not stem cells.

These physicians can order and infuse stem cells and CAR T cells

Physician investigators will review a lecture on the role of cellular therapies in relapse/refractory multiple myeloma/RRMM that discusses current information in regards to available cellular therapies in RRMM and a proposed treatment algorithm.

Lecture on the role of cellular therapies in relapse/refractory multiple myeloma/RRMM

Depression and anxiety will be assessed using the Hospital Anxiety and Depression Scale (HADS), a 14-item self-rated questionnaire

Hospital Anxiety and Depression Scale

A 14-item, self-administered, multidimensional, functional social support questionnaire has been reduced to an 11 items to a brief and easy-to-complete two-scale, eight-item functional social support instrument.

Duke-UNC Functional Social Support Questionnaire

The Distress Thermometer is a single-item visual analog scale used to screen cancer patients for the presence of psychological distress

Distress Thermometer

The FACT-BMT Version 4.0 is a 37 item self-report questionnaire that measures the effect of cancer on Quality of Life domains

FACT-BMT

The PACT scale is a single page 10-item rating scale with high inter-rater reliability that has been used extensively in solid organ transplantation

Psychosocial Assessments of Candidates for Transplantation

Heather Landau, MD

Carlyn Tan, MD

This is an observational study that will include both participants with relapsed/refractory Multiple Myeloma and their doctors. The purpose of this study is to gather information about the use of hematopoietic cell transplantation/HCT and B-cell maturation antigen /BCMS targeted chimeric antigen receptor/CAR autologous T-cell therapy.

A Study to Identify Barriers to Cellular Therapies for People With Plasma Cell Disorders

Prospective Multi-Center Study to Identify Barriers to Cellular Therapies in Patients With Plasma Cell Disorders PROACT PCD

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

To prospectively estimate the rates of referral and utilization of salvage autologous hematopoietic cell transplantation (HCT) and B cell maturation antigen (BCMA) Targeted Chimeric Antigen Receptor (CAR) autologous T cell therapies among patients with RRMM.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Study to Identify Barriers to Cellular Therapies for People With Plasma Cell Disorders	NCT06126341	Multiple Myelom...	Lecture on the ... Hospital Anxiet... Duke-UNC Functi... Distress Thermo... FACT-BMT Psychosocial As...	18 Years - 80 Years	Memorial Sloan Kettering Cancer Center
A Study to Identify Barriers to Cellular Therapies for People With Plasma Cell Disorders	NCT06126341	Multiple Myelom...	Lecture on the ... Hospital Anxiet... Duke-UNC Functi... Distress Thermo... FACT-BMT Psychosocial As...	18 Years - 80 Years	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for psychosocial assessments of candidates for transplantation