Neoplasms

Gland and Hormone Related Diseases

All Conditions

Rare Diseases

Thyroid Neoplasms

Thyroid Diseases

Hypoparathyroidism

Endocrine System Diseases

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Parathyroid Diseases

All Drugs and Chemicals

Parathyroid Hormone

1. Use near-infrared equipment to detect surgical specimens; 2. Timing near-infrared equipment detects parathyroid glands and takes photography; 3. recording the positive tissue in NIRAF; 4. analyzing the accuracy of NIR equipment to see positive points.

1. Senior Surgeon inspects for parathyroid glands in postoperative thyroid specimens with the naked eye; 2. Timing senior doctors with parathyroid glands; 3. PTH test strips confirm all suspicious tissues. 4. all analyzing the accuracy of the positive points of senior doctors.

This device can emit and collect near-infrared light of a specific wavelength. The parathyroid glands in the specimen appear as a high-brightness image in the device, to find the parathyroid gland that may be accidentally removed from the specimen.

Near-infrared devices

The PTH test strip is to detect the PTH in the specimen by immunocolloidal gold technology to determine whether it is parathyroid.

PTH test strip

This is a prospective study aiming to establish near-infrared autofluorescence technology and PTH test strip as a standardized process for finding and identifying parathyroid glands in thyroid surgery.

This is a prospective study aiming to establish near-infrared autofluorescence technology and PTH test strip as a standardized process for finding and identifying parathyroid glands in thyroid surgery.

NIFRA first photographed all specimens from thyroidectomy with or without central neck dissection, and positive tissues under near-infrared light were recorded in a neck map. Then, a senior surgeon examined the parathyroid glands with the naked eye. These suspicious tissues were then identified with the PTH test strip as a gold standard. Finally, the parathyroid glands discovered during the operation that could not be preserved in situ were excluded from the procedure comparison and classified as strategic parathyroid transplantation.

Thyroid surgical specimens, including the thyroid gland, central compartment lymph nodes, and adipose tissue, may include ischemic parathyroid glands. These parathyroid glands, if exist, will transplant back into the patient's body after they are identified.

Near-Infrared Autofluorescence With PTH Test Strip as an SOP of Parathyroid in Thyroid Surgery

Surgical specimens were photographed with NIRAF, and the location and amount of positive tissue were recorded and marked on the neck map.

Surgeons looked for suspicious parathyroid tissue with the naked eye and divided them into less than 10% confidence group, 10-90% confidence group, and greater than 90% confidence group. These tissues are tested with PTH strips to confirm that they are parathyroid tissue.

The parathyroid glands that had been discovered during the operation that could not be preserved in situ were excluded from the procedure comparison and classified as strategic parathyroid transplantation.

The number of parathyroid glands in pathological report

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Near-Infrared Autofluorescence With PTH Test Strip as an SOP of Parathyroid in Thyroid Surgery	NCT05684029	Thyroid Cancer Hypoparathyroid... Optical Imaging	Near-infrared d... PTH test strip	12 Years - 70 Years	Fujian Medical University
Near-Infrared Autofluorescence With PTH Test Strip as an SOP of Parathyroid in Thyroid Surgery	NCT05684029	Thyroid Cancer Hypoparathyroid... Optical Imaging	Near-infrared d... PTH test strip	12 Years - 70 Years	Fujian Medical University

Spots Global Cancer Trial Database for pth test strip