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Patients will receive pyruvic acid solution 70% prepared by solving of pyruvic acid in water/ethanol solution. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid.

Patients will receive a combination of salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid.

Pyruvic acid

Fatima Assaf, M.D.

Plantar warts can be bothersome and painful requiring treatment. The investigators will compare the efficacy of pyruvic acid and salicylic acid in treating multiple plantar warts. Patients with multiple plantar warts will be randomized to receive either pyruvic acid 70% or compound salicylic acid solution (salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%) applying topically twice a day for 4 weeks. Patients will be visited every 2 weeks for one month after starting treatment and then every one month for up to 3 months. The number and size of warts will be evaluated.

Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts

Comparison of 70% Pyruvic Acid Solution and Duofilm Solution in Treatment of Plantar Wart

Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the number of warts. Any wart totally non-detectable by inspection and touch will be considered as healed.

Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the size of warts. The size of the warts will be calculated as the mean size of all the warts.

Isfahan University of Medical Sciences

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts	NCT02151630	Plantar Wart	Pyruvic acid Salicylic Acid	12 Years -	Isfahan University of Medical Sciences
Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts	NCT02151630	Plantar Wart	Pyruvic acid Salicylic Acid	12 Years -	Isfahan University of Medical Sciences

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