Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Symptoms and General Pathology

Behaviors and Mental Disorders

Prostatic Neoplasms

Disease Progression

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Quality of Life

All Drugs and Chemicals

Androgens

Standard care, currently ADT +/- other systemic therapies.

To add radical prostatectomy on the basis of current standard of care for those with oligometastatic prostate cancer

Radical prostatectomy plus standard care

androgen deprivation therapy with or without other systemic therapies based on current guidelines for metastatic prostate cancer

Standard of care for metastatic prostate cancer

Jian-Ming Guo, MD, PhD

Lei Xu, MD, PhD

This study is to examine whether radical prostatectomy can impact survival and quality-of-life in men with oligo-metastatic prostate cancer.

In this study, patients with oligo-metastatic prostate cancer will be randomized to radical prostatectomy plus standard care and standard care only. Standard care refers to androgen deprivation therapy (ADT) +/- other systemic therapies. Time to disease progression and post-treatment quality of life will be assessed and compared.

Testing Radical Prostatectomy in Chinese Men With Prostate Cancer and oligoMetastases to the Bone

Zhongshan Hospital, Fudan University

The time to treatment failure defined as castrate resistance will be recorded via routine patient follow-up interviews.

EuroQOL 5 dimensions 5 levels (EQ-5D-5L) questionnaire will be used to assess quality of life in patients after randomization with different treatments. This is designed to measure health-related quality of life. It consists of a questionnaire and a visual analogue scale. The subjects in 5 dimensions i.e. mobility, self-care, usual activities, pain/discomfort and anxiety/depression are asked to grade their own current level of function in each dimension into one of five levels of disability (i.e. I have no problems waling about, slight problems, moderate problems, severe problems, or unable to walk). This tool also has an overall health scale where the rater selects a number between 1-100 to describe the condition of their health, 100 being the best imaginable.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Testing Radical Prostatectomy in Chinese Men With Prostate Cancer and oligoMetastases to the Bone	NCT03988686	Prostate Cancer...	Radical prostat... Standard of car...	18 Years - 75 Years	Fudan University
Testing Radical Prostatectomy in Chinese Men With Prostate Cancer and oligoMetastases to the Bone	NCT03988686	Prostate Cancer...	Radical prostat... Standard of car...	18 Years - 75 Years	Fudan University

Spots Global Cancer Trial Database for radical prostatectomy plus standard care