Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

Antineoplastic Agents

All Drugs and Chemicals

Carboplatin

Pemetrexed

Ranpirnase

Enzyme Inhibitors

All patients who do not progress after two cycles of pemetrexed-carboplatin will receive the study drug, ranpirnase

Cycles 3 and until patient progression, on days 1,8 and 15 in a 21 day cycle

The purpose of the trial is to determine the rate of improvement in objective tumor response, following the addition of ranpirnase to ongoing pemetrexed-carboplatin chemotherapy, for patients with SD or PR following 2 cycles of doublet chemotherapy.

A Study Of Ranpirnase(Onconase®) To Pemetrexed Plus Carboplatin In Patients With Non-Squamous Non-Small Cell Lung Cancer

A Phase II Trial of Addition of Ranpirnase(ONCONASE®) to Permetrexed Plus Carboplatin in Patientes With Non-Squamous Non-Small Cell Lung Cancer

To determine the rate of improvement in objective tumor response, following the addition of ranpirnase to ongoing pemetrexed-carboplatin chemotherapy, for patients with SD or PR following 2 cycles of doublet chemotherapy

To determine the PFS in patients with SD, PR or CR following 2 cycles of doublet chemotherapy

To determine the survival of patients with SD, PR or CR following 2 cycles of doublet chemotherapy

Tamir Biotechnology, Inc.

Charles Muniz

Infections

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Skin and Connective Tissue Diseases

Communicable Diseases

Condylomata Acuminata

Sexually Transmitted Diseases

Papillomavirus Infections

Warts

Genital Diseases

Urogenital Diseases

Disease Attributes

Sexually Transmitted Diseases, Viral

Virus Diseases

DNA Virus Infections

Tumor Virus Infections

Skin Diseases

Skin Diseases, Viral

Skin Diseases, Infectious

Pharmaceutical Solutions

1 mg/ml solution of ranpirnase applied twice daily

Vehicle

Edgar Valdez, MD

Ranpirnase in topical formulation is an antiviral drug being evaluated for the topical treatment of anogenital warts. The aims of this study is to evaluate the efficacy and safety of a topical formulation of ranpirnase in subjects with genital warts.

The study consists of the evaluation of 4 weeks exposure to the study product; designed as randomized, double blinded, against vehicle to study the effects of 1 mg/ml concentration of ranpirnase on anogenital warts.

The dermal reaction are scored on a scale that describes the amount of erythema, edema, and other features indicative of irritation.

The clinical response are be scored on the basis of the percentage of the reduction of the lesions in size and number.

Safety and Efficacy Study of Topical Ranpirnase to Treat Genital Warts (HPV)

Phase II Clinical Study, Double Blinded, Multicentric, Controlled Against Placebo, in Parallel Groups, to Evaluate the Efficacy and Safety of a Topical Product Containing Ranpirnase in Genital Warts - HPV

The primary endpoint is the percentage change from baseline in total area of lesions at Week 8

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Study Of Ranpirnase(Onconase®) To Pemetrexed Plus Carboplatin In Patients With Non-Squamous Non-Small Cell Lung Cancer	NCT01184287	Non-Small Cell ...	Ranpirnase	18 Years -	Tamir Biotechnology, Inc.
Safety and Efficacy Study of Topical Ranpirnase to Treat Genital Warts (HPV)	NCT02535104	Condylomata Acu... Papillomavirus ... Sexually Transm...	Ranpirnase Vehicle	18 Years - 60 Years	Tamir Biotechnology, Inc.
A Study Of Ranpirnase(Onconase®) To Pemetrexed Plus Carboplatin In Patients With Non-Squamous Non-Small Cell Lung Cancer	NCT01184287	Non-Small Cell ...	Ranpirnase	18 Years -	Tamir Biotechnology, Inc.
Safety and Efficacy Study of Topical Ranpirnase to Treat Genital Warts (HPV)	NCT02535104	Condylomata Acu... Papillomavirus ... Sexually Transm...	Ranpirnase Vehicle	18 Years - 60 Years	Tamir Biotechnology, Inc.

Spots Global Cancer Trial Database for ranpirnase

Every month we try and update this database with for ranpirnase cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for ranpirnase

Every month we try and update this database with for ranpirnase cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for ranpirnase cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.