Neoplasms

Digestive System Diseases

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Rectal Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Intestinal Diseases

Rectal Diseases

Intensity modulated radiotherapy, dose escalation, rectal cancer, volumetric modulated arc therapy

Intensity modulated radiotherapy to a dose of 55Gy in 25 fractions

Intensity Modulated Radiotherapy

Jeremy Tey, FRANZCR

The hypothesis of this study is that dose escalated intensity modulated radiotherapy (IMRT) to a dose of 55Gy in 25# to primary rectal tumor concurrent with oral capecitabine results in an improved pathological response rate from 8% (German trial) to 25%.

This study aims to look at whether radiation dose escalation with intensity modulated radiotherapy can increase the rates of pathological complete response in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy

Preoperative Concurrent Chemotherapy and Intensity Modulated Radiotherapy (IMRT) in Locally Advanced Rectal Cancer

A Phase II Trial of Preoperative Concurrent Chemotherapy and (IMRT) in Locally Advanced Rectal Cancer

Pathogical complete response rate 8 weeks post chemoradiotherapy at surgery according to Ryan's classification

Toxicity including anorexia, nausea, vomiting, diarrhoea, dermatitis, proctitis, urinary frequency/urgency as per common toxicity criteria v3.0

Time from study entry to disease recurrence or death

percentage of patients who achieve downstaging 8 weeks post chemoradiotherapy at surgery according to TNM classification

Sphincter Preservation rates 8 weeks post chemoradiotherapy at surgery.Percentage of patients who underwent sphincter salvage surgery after chemoradiotherapy

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Preoperative Concurrent Chemotherapy and Intensity Modulated Radiotherapy (IMRT) in Locally Advanced Rectal Cancer	NCT01340508	Rectal Cancers.	Intensity Modul...	21 Years - 90 Years	National University Hospital, Singapore
Preoperative Concurrent Chemotherapy and Intensity Modulated Radiotherapy (IMRT) in Locally Advanced Rectal Cancer	NCT01340508	Rectal Cancers.	Intensity Modul...	21 Years - 90 Years	National University Hospital, Singapore

Spots Global Cancer Trial Database for rectal cancers.